Morpholine-d8 1 | CAS No.: 342611-02-3

Morpholine-d8 | CAS 342611-02-3

Chemical Name: Morpholine-d8
Synonyms: Fully deuterated morpholine, Tetrahydro-1,4-oxazine-d8
Molecular Formula: C₄D₈NO
Molecular Weight: 94.17 g/mol
CAS Number: 342611-02-3
Isotopic Labeling: Fully deuterated (d8)

Overview

Morpholine-d8 is the fully deuterated analog of morpholine, a six-membered heterocyclic compound containing both oxygen and nitrogen atoms. All eight hydrogen atoms in the parent compound are replaced by deuterium, resulting in a stable isotope-labeled reagent with the same chemical reactivity but a distinct mass shift for analytical applications.

This compound is widely utilized in NMR spectroscopy, mass spectrometry, and kinetic isotope effect studies, where deuteration enhances structural elucidation, signal separation, and metabolic tracking accuracy.

Applications

• NMR Solvent and Reference Material:
  Morpholine-d8 is used as a deuterated internal standard and solvent for ¹H and ¹³C NMR spectroscopy, providing background-free spectra and reliable chemical shift referencing.

• Mass Spectrometry and Isotope Tracing:
  The d8 isotope label introduces a predictable mass difference, making it ideal for GC-MS and LC-MS/MS quantitation, isotopic dilution assays, and tracer studies in biological or chemical systems.

• Kinetic Isotope Effect (KIE) Research:
  Used in mechanistic and enzymatic studies to investigate reaction pathways, hydrogen-deuterium exchange kinetics, and catalytic isotope effects.

• Organic and Medicinal Chemistry Research:
  Serves as a model compound for understanding solvent effects, ring stability, and proton-exchange phenomena in heterocyclic chemistry.

Quality and Manufacturing

At ResolveMass Laboratories Inc., Morpholine-d8 is produced under strict ISO 9001:2015 quality standards and undergoes rigorous analytical characterization by NMR, GC-MS, and FTIR to confirm isotopic incorporation and purity. Each batch is supplied with a Certificate of Analysis (CoA) detailing isotopic distribution and analytical data.

Custom synthesis and bulk-scale production are available for research, pharmaceutical, and analytical laboratories requiring consistent isotopic standards.

Ordering Information

For product inquiries, CoA requests, or custom isotope labeling projects, contact info@resolvemass.com.
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