N-Methyl-d3-Pyrrolidine | CAS 77422-30-1

OVERVIEW  of  N-Methyl-d3-Pyrrolidine | CAS 77422-30-1

 

N-Methyl-d3-pyrrolidine (CAS 77422-30-1) is a deuterium-labeled cyclic secondary amine containing three deuterium atoms on the N-methyl group. This isotopic substitution provides distinct mass separation while preserving the native chemical and physical characteristics of pyrrolidine derivatives.
Because of its stability, high isotopic enrichment, and structural equivalence, N-Methyl-d3-pyrrolidine is widely used as an internal standard in LC-MS and GC-MS analysis, especially in pharmaceutical impurity monitoring, metabolic profiling, and toxicological assays. It also serves as a valuable building block in synthetic chemistry and mechanistic isotope studies.

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CHEMICAL INFORMATION

Chemical Name: N-Methyl-d3-pyrrolidine
Synonyms: Deuterated N-methylpyrrolidine, Pyrrolidine-d3 derivative
CAS Number: 77422-30-1
Molecular Formula: C₅H₈D₃N
Molecular Weight: 88.17 g/mol
Isotopic Enrichment: ≥98 atom % D
Functional Groups: Secondary amine, deuterated N-methyl group

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APPLICATIONS  of  N-Methyl-d3-Pyrrolidine | CAS 77422-30-1

• LC-MS & GC-MS Internal Standard: Ideal for quantifying pyrrolidine derivatives, amine-containing drugs, impurities, and metabolites.

• Pharmaceutical Development: Supports impurity profiling, kinetic studies, and reaction monitoring in medicinal chemistry.

• Toxicology & Forensic Analysis: Useful for detecting amine-based compounds in biological matrices.

• Isotope-Dilution Quantitation: Enhances accuracy in complex samples, including plasma, urine, and environmental extracts.

• Synthetic & Mechanistic Chemistry: Deuterium labeling aids in studying reaction mechanisms, hydrogen-deuterium exchange, and N-methylation pathways.

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FEATURES & BENEFITS

• High Isotopic Purity: Ensures clear mass differentiation and reliable quantitation.

• Stable Under Analytical Conditions: Maintains isotopic labeling during sample prep and chromatographic separation.

• Chemically Equivalent to Native Compound: Perfect for comparative studies and IDMS workflows.

• Low Matrix Interference: Produces clean mass spectra in biological, pharmaceutical, and environmental samples.

• Versatile Research Utility: Applicable across pharmaceutical R&D, toxicology, metabolomics, and organic synthesis.

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SUMMARY

N-Methyl-d3-pyrrolidine (CAS 77422-30-1) is a high-quality deuterated secondary amine widely used as an internal standard for mass spectrometry and mechanistic chemistry. With three deuterium atoms on the N-methyl group and excellent isotopic enrichment, it delivers exceptional precision for quantitative LC-MS/GC-MS assays and synthetic research. ResolveMass Laboratories Inc. supplies this compound with superior purity suitable for advanced analytical and pharmaceutical applications.

 

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