n-Propyl-2,2,3,3,3-d5 Alcohol | CAS 64118-40-7

OVERVIEW  of  n-Propyl-2,2,3,3,3-d5 Alcohol | CAS 64118-40-7

n-Propyl-2,2,3,3,3-d₅ alcohol (CAS 64118-40-7) is a highly deuterated analog of n-propanol, containing five deuterium atoms substituted at the terminal carbon positions. Because of its distinct mass shift and chemical similarity to native n-propanol, it is widely used as an internal standard in GC-MS and LC-MS, as well as in metabolic and tracer studies.

CHEMICAL INFORMATION

• Name: n-Propanol-d₅

• Molecular Formula: C₃D₅H₅O

• Molecular Weight: 65.14 g/mol

• CAS Number: 64118-40-7

• Isotopic Enrichment: Typically ≥ 98 atom % D

• Chemical Class: Deuterated primary alcohol

• Solubility: Miscible with water and organic solvents

APPLICATIONS  of  n-Propyl-2,2,3,3,3-d5 Alcohol | CAS 64118-40-7

• Mass Spectrometry Internal Standard:
  Ideal for isotope-dilution GC-MS/LC-MS quantification of n-propanol in pharmaceuticals, biological fluids, food matrices, and environmental samples.

• VOC & Environmental Monitoring:
  Used in detecting and quantifying alcohol-based VOC emissions and solvent residues.

• Biochemical & Metabolic Tracing:
  Useful in studies of alcohol metabolism, microbial fermentation, and biochemical transformation pathways.

• Analytical Method Validation:
  Supports calibration curves, extraction efficiency studies, accuracy checks, and spike-and-recovery experiments.

• NMR Applications:
  Deuterium labeling enhances ²H NMR signal clarity and reduces background proton interference.

ADVANTAGES  of  n-Propyl-2,2,3,3,3-d5 Alcohol | CAS 64118-40-7

• High deuterium enrichment ensures clean mass separation from native n-propanol.

• Co-elutes with the unlabeled molecule for accurate quantification.

• Chemically stable, easy to handle, and suitable for long-term analytical use.

• Compatible across multiple analytical platforms and sample types.

HANDLING AND SAFETY

• Handling: Use gloves and eye protection; avoid inhalation or skin contact.

• Hazards: Similar to standard n-propanol; flammable liquid and vapor.

• Storage: Keep in a well-ventilated area, away from ignition sources.

• Disposal: Follow local/regional guidelines for organic solvent waste.

SUMMARY
n-Propyl-2,2,3,3,3-d₅ alcohol (CAS 64118-40-7) is a high-purity, deuterium-labeled primary alcohol widely used in analytical chemistry and tracer studies. Its excellent isotopic stability and structural similarity to native n-propanol make it an essential standard for high-precision quantitative workflows.