Netoglitazone M1 | CAS 161600-03-9

Netoglitazone M1 (CAS 161600-03-9) is a significant metabolite of Netoglitazone, a thiazolidinedione (TZD) class compound investigated for the management of metabolic disorders, including type 2 diabetes mellitus. As a metabolite reference standard, Netoglitazone M1 plays an important role in pharmaceutical research, drug metabolism studies, impurity profiling, and bioanalytical method development. It is widely used by pharmaceutical companies, CROs, academic researchers, and regulatory laboratories involved in preclinical and clinical drug development.

Accurate identification and quantification of drug metabolites are essential for understanding a drug’s pharmacokinetic profile, metabolic pathways, safety, and regulatory compliance. Regulatory agencies such as the FDA, EMA, and Health Canada expect sponsors to adequately characterize major metabolites during drug development, making authenticated reference materials like Netoglitazone M1 valuable for analytical laboratories.

Chemical Properties of Netoglitazone M1

Applications of Netoglitazone M1

Netoglitazone M1 is extensively utilized across multiple stages of pharmaceutical research and analytical testing. Its primary applications include:

• LC-MS/MS and LC-HRMS method development and validation
• Pharmacokinetic (PK) and ADME studies
• Drug metabolism and metabolite identification
• Bioanalytical assay development
• Impurity profiling and degradation studies
• Stability-indicating analytical methods
• Toxicology investigations
• Reference standard qualification
• Regulatory submission support
• Clinical and non-clinical research

The availability of a well-characterized metabolite standard enables laboratories to achieve accurate metabolite identification while improving analytical confidence during regulated studies.

Importance in Drug Metabolism Studies

Understanding metabolite formation is a critical component of modern drug development. Drug metabolites can contribute to therapeutic efficacy, toxicity, drug-drug interactions, and overall safety profiles. Characterizing these metabolites helps researchers determine metabolic pathways, identify major circulating metabolites, and assess exposure during clinical development.

Netoglitazone M1 serves as an analytical benchmark for evaluating metabolite formation in biological matrices such as plasma, serum, urine, and tissue samples. Its use supports reliable quantitative and qualitative analyses during preclinical and clinical investigations.

Comprehensive metabolite characterization is also important for meeting international regulatory expectations for metabolite safety assessment and pharmacokinetic evaluation.

Analytical Techniques Supported

Netoglitazone M1 is compatible with a wide range of advanced analytical platforms used in pharmaceutical laboratories, including:

• Liquid Chromatography–Mass Spectrometry (LC-MS/MS)
• High-Resolution Mass Spectrometry (HRMS)
• UHPLC
• HPLC with UV detection
• Tandem Mass Spectrometry
• Accurate Mass Analysis
• Stability-indicating chromatographic methods

These analytical techniques enable precise identification, quantification, structural confirmation, and impurity monitoring throughout the drug development lifecycle.

Role in Bioanalytical Method Development

Bioanalytical methods require highly characterized reference materials to ensure reliable quantification of analytes in biological samples. Netoglitazone M1 can be employed during:

• Calibration curve preparation
• Quality control sample generation
• Method validation
• Selectivity assessment
• Precision and accuracy studies
• Matrix effect evaluation
• Recovery experiments
• Stability studies

The use of authenticated reference standards contributes to reproducible analytical performance while supporting compliance with regulatory guidance for bioanalytical method validation.

Pharmaceutical Research Applications

Researchers investigating thiazolidinedione-based molecules frequently require metabolite standards to better understand metabolic transformations and disposition profiles. Netoglitazone M1 can support:

• Lead optimization studies
• Candidate selection
• Comparative metabolism investigations
• In vitro microsomal metabolism studies
• Hepatocyte metabolism experiments
• Enzyme phenotyping
• Drug-drug interaction research
• Translational pharmacology studies

These applications provide valuable information during both early discovery and late-stage pharmaceutical development.

Quality and Characterization

At ResolveMass Laboratories Inc., reference standards are supported by comprehensive analytical characterization to provide confidence in identity and quality. Characterization may include:

• High-performance liquid chromatography (HPLC)
• LC-MS/MS analysis
• High-resolution mass spectrometry
• Nuclear magnetic resonance (NMR), where applicable
• Certificate of Analysis (CoA)
• Identity confirmation
• Purity assessment

Such analytical documentation helps researchers maintain consistency across method development, validation, and routine analytical testing.

Why Choose ResolveMass Laboratories Inc.?

ResolveMass Laboratories Inc. supports pharmaceutical and biotechnology organizations with high-quality analytical reference standards and advanced analytical services. Our scientific expertise in mass spectrometry, impurity characterization, metabolite identification, and pharmaceutical analysis enables us to deliver reliable products that support research and regulatory requirements.

Our team understands the analytical challenges associated with metabolite characterization and works closely with clients to provide scientifically robust reference materials suitable for pharmaceutical R&D, bioanalysis, and quality control laboratories.

Whether supporting early-stage discovery, regulated bioanalytical studies, or commercial analytical testing, ResolveMass Laboratories is committed to delivering dependable analytical solutions backed by scientific expertise and rigorous quality standards.

For additional information regarding Netoglitazone M1 (CAS 161600-03-9), product availability, analytical documentation, or custom analytical services, contact the scientific team at ResolveMass Laboratories Inc. to discuss your specific research and development requirements.

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CID 204109