N,N-Dimethylethanolamine-d10 (OH) | CAS 257957-94-0

OVERVIEW  of  N,N-Dimethylethanolamine-d10 (OH) | CAS 257957-94-0

N,N-Dimethylethanolamine-d10 (CAS 257957-94-0) is a fully deuterated analogue of N,N-dimethylethanolamine (DMEA) in which all hydrogen atoms are replaced with deuterium. This compound serves as an isotopically labeled reagent and analytical standard in a variety of applications, including mass spectrometry (MS), nuclear magnetic resonance (NMR) spectroscopy, and pharmaceutical research. The replacement of hydrogen with deuterium provides increased molecular stability and allows for clear differentiation of labeled and unlabeled species in analytical and metabolic studies.

N,N-Dimethylethanolamine-d10 (OH) is particularly valuable for metabolic tracing, mechanistic investigations, and internal standard calibration in analytical chemistry. It maintains the same chemical behavior as its non-deuterated form but exhibits distinct isotopic properties, making it essential for accurate isotope-ratio determinations and quantitative analyses.

CHEMICAL INFORMATION

• Name: N,N-Dimethylethanolamine-d10

• Molecular Formula: C₄D₁₀NO

• Molecular Weight: 94.18 g/mol

• CAS Number: 257957-94-0

• Isotopic Labeling: Fully deuterated (10 deuterium atoms)

• Chemical Class: Deuterated alkanolamine

• Stability: Stable under recommended storage conditions; hygroscopic in nature

APPLICATIONS  of  N,N-Dimethylethanolamine-d10 (OH) | CAS 257957-94-0

• Mass Spectrometry (MS):
  Used as a stable isotopic internal standard for quantifying DMEA and related ethanolamine derivatives in biological and environmental samples.

• NMR Spectroscopy:
  Serves as a reference compound in NMR experiments for calibration, solvent suppression, and spectral interpretation.

• Pharmaceutical and Metabolite Research:
  Utilized in metabolic profiling and drug metabolism studies, especially where N,N-dimethylethanolamine or related metabolites are investigated.

• Analytical Chemistry:
  Employed in quantitative analysis and isotope dilution methods to improve accuracy and reproducibility.

• Synthetic Chemistry:
  Functions as an isotopically labeled intermediate in the synthesis of deuterated pharmaceuticals, surfactants, and quaternary ammonium compounds.

ADVANTAGES  of  N,N-Dimethylethanolamine-d10 (OH) | CAS 257957-94-0

• Fully deuterated (≥ 98 atom % D), ensuring clear isotopic differentiation.

• Chemically equivalent to the non-deuterated analogue, allowing direct substitution in experimental setups.

• High chemical and isotopic purity for precise analytical results.

• Excellent stability under standard laboratory conditions.

• Non-radioactive and environmentally safe isotope labeling alternative.

HANDLING, STORAGE & SAFETY

• Handling: Handle under dry conditions; avoid prolonged exposure to air or humidity.

• Storage: Keep in tightly closed amber bottles at 2–8 °C.

• Safety: Low toxicity; may cause mild irritation upon contact with skin or eyes. Use protective gloves and goggles.

• Disposal: Dispose of waste according to local environmental and chemical safety regulations.

QUALITY & SPECIFICATION

• Purity: ≥ 98 % (chemical)

• Isotopic Enrichment: ≥ 98 atom % D

• Analytical Verification: Confirmed by ¹H NMR (absence of proton peaks), ²H NMR, GC–MS, and IR spectroscopy

• Documentation: Certificate of Analysis (CoA) and Safety Data Sheet (SDS) available upon request

SUMMARY
N,N-Dimethylethanolamine-d10 (CAS 257957-94-0) is a high-purity deuterated compound essential for analytical, pharmaceutical, and chemical research. Its full deuterium labeling makes it an ideal internal standard for mass spectrometry and NMR studies, offering superior isotopic precision and reproducibility. With its stability, solubility, and reliability, this compound plays a crucial role in metabolic tracing, isotope-ratio quantification, and synthesis of labeled intermediates, supporting advanced applications in scientific and industrial research.