Propionic-d5-acid | CAS 60153-92-6

OVERVIEW  of  Propionic-d5-acid | CAS 60153-92-6

Propionic-d₅-acid (CAS 60153-92-6) is a fully deuterated analog of propionic acid, in which five hydrogen atoms are replaced by deuterium. This isotopically labeled compound has the molecular formula C₃D₅O₂H and a molecular weight of approximately 78.11 g/mol. The deuteration enhances its utility as a stable isotope-labeled standard in a wide range of analytical, biochemical, and environmental applications.

This compound mirrors the physical and chemical properties of natural propionic acid while providing a distinctive isotopic signature that allows for precise quantification and tracking using gas chromatography–mass spectrometry (GC-MS) and liquid chromatography–mass spectrometry (LC-MS). Due to its high isotopic enrichment and purity, Propionic-d₅-acid is extensively utilized in metabolomic profiling, food chemistry, and stable isotope tracer studies.

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CHEMICAL INFORMATION

• Name: Propionic-d₅-acid

• Synonyms: Propanoic-d₅ acid; Deuterated propionic acid; Propionic acid-d₅

• CAS Number: 60153-92-6

• Molecular Formula: C₃D₅O₂H

• Molecular Weight: 79.11 g/mol

• Isotopic Enrichment: ≥98 atom % D

• Chemical Structure: CH₃CH₂COOH (with five deuterium atoms substituting hydrogen)

• Solubility: Miscible with water, ethanol, and most organic solvents

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APPLICATIONS  of  Propionic-d5-acid | CAS 60153-92-6

1. Mass Spectrometry and Chromatographic Analysis
Propionic-d₅-acid is widely used as a reference standard and internal standard in GC-MS and LC-MS for the quantification of propionic acid and other short-chain fatty acids (SCFAs). Its distinct mass shift enables accurate measurement without interference from naturally occurring isotopes, ensuring reliable and reproducible analytical results.

2. Metabolomics and Stable Isotope Tracing
In metabolomic and isotopic labeling studies, Propionic-d₅-acid serves as a metabolic tracer to investigate biochemical pathways involving fatty acid synthesis, β-oxidation, and energy metabolism. It allows researchers to distinguish between endogenous and exogenous sources of propionate, providing key insights into microbial fermentation, host-microbiome interactions, and carbon flow in biological systems.

3. Food and Nutritional Research
Propionic acid and its salts are commonly used as preservatives in bakery and dairy products. The deuterated form, Propionic-d₅-acid, provides an excellent analytical tool for quantifying propionate residues and studying fermentation by-products in food matrices. It supports high-accuracy measurement in compliance testing and nutritional quality assessment.

4. Environmental and Biochemical Studies
Propionic-d₅-acid is utilized in environmental chemistry as a tracer molecule to study carbon cycling, microbial activity, and biodegradation processes in soil and aquatic ecosystems. It helps in understanding how organic acids behave, transform, and integrate into ecological and industrial systems.

5. Pharmaceutical and Biomedical Research
Propionate plays important physiological roles in lipid metabolism, glucose regulation, and gut health. The labeled analog Propionic-d₅-acid aids in pharmacokinetic investigations, supporting the development of therapeutics and nutritional supplements that target short-chain fatty acid pathways.

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ADVANTAGES  of  Propionic-d5-acid | CAS 60153-92-6

• High Isotopic Purity (≥98 atom % D): Enables clear spectral separation and enhanced analytical confidence.

• Stable and Non-Radioactive: Safe for laboratory handling and long-term studies.

• Excellent Compatibility: Suitable for both aqueous and organic analytical systems.

• Accurate Quantification: Ideal for use as an internal standard in isotope dilution mass spectrometry (IDMS).

• Reliable Reproducibility: Maintains chemical behavior identical to the native propionic acid.

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RESEARCH SIGNIFICANCE
Propionic-d₅-acid is an essential compound in modern metabolomics, microbial fermentation research, and nutritional science. As one of the primary short-chain fatty acids produced in the gut microbiota, propionate is a key energy substrate and signaling molecule in human and animal physiology. By employing its deuterated analog, scientists can track propionate’s synthesis, transport, and metabolic conversion with high precision.

In analytical chemistry, it serves as a benchmark compound for quantifying trace propionate levels in environmental samples, food matrices, and biological fluids. In microbiology, it facilitates studies on carbon utilization and microbial pathway regulation. Furthermore, its stability and non-toxic nature make it an ideal reagent for long-term kinetic and flux analyses.

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SUMMARY
Propionic-d₅-acid (CAS 60153-92-6) is a high-purity, deuterium-labeled carboxylic acid designed for use in advanced analytical and biochemical applications. Its isotopic enrichment (≥98 atom % D) and structural similarity to native propionic acid enable unparalleled accuracy in isotope ratio, quantitative, and tracer studies.

At ResolveMass Laboratories Inc., Propionic-d₅-acid is produced under stringent quality control to ensure consistency, purity, and performance for both research and analytical laboratories. It is an indispensable reference material for scientists engaged in metabolomic research, mass spectrometry-based quantification, and stable isotope tracing across environmental, biological, and industrial fields.

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Pubchem Id: 329758693