Quinaldic-d6 acid | CAS 1219802-18-2

OVERVIEW  of  Quinaldic-d6 acid | CAS 1219802-18-2

 

Quinaldic-d6 Acid | CAS 1219802-18-2  is a fully deuterium-labeled derivative of quinaldic acid, a quinoline-based heterocyclic carboxylic acid widely used in pharmaceutical, biochemical, and analytical research. The six deuterium atoms incorporated into the aromatic ring significantly enhance its utility as an internal standard, metabolic tracer, and reference material in high-precision quantitative workflows. Its structural stability, isotopic enrichment, and excellent chromatographic behavior make it ideal for LC-MS/MS assays, impurity tracking, and mechanistic pathway studies.

This compound is particularly valuable in analytical methods where quinaldic acid or related quinoline metabolites are monitored, enabling accurate quantitation even in complex biological or chemical matrices. Researchers working in synthetic chemistry, drug metabolism, and isotope-dilution analysis rely on Quinaldic-d6 Acid to achieve reproducible, interference-free results.

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CHEMICAL INFORMATION

• Chemical Name: Quinaldic-d6 Acid

• Synonyms: 2-Quinolinecarboxylic-d6 Acid

• CAS Number: 1219802-18-2

• Molecular Formula: C₁₀D₆H₃NO₂

• Isotopic Labeling: Six deuterium atoms incorporated into the aromatic quinoline ring

• Chemical Class: Deuterium-labeled heterocyclic carboxylic acid

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KEY FEATURES

• High isotopic enrichment ensures precise isotope-dilution quantification

• Excellent LC-MS compatibility with stable ionization and predictable fragmentation

• Deuterium labeling on the aromatic ring provides strong mass separation from the non-labeled analog

• Chemically stable and non-exchangeable deuterium atoms maintain labeling integrity during analysis

• Consistent retention behavior suitable for validated analytical methods

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APPLICATIONS  of  Quinaldic-d6 acid | CAS 1219802-18-2

 

1. LC-MS/MS INTERNAL STANDARD

Quinaldic-d6 Acid is widely used as an internal standard in quantitative LC-MS assays for quinaldic acid and related quinoline derivatives. Because the labeled and unlabeled compounds co-elute while maintaining a clear mass shift, this internal standard compensates for matrix effects, ion suppression, and extraction variability.

2. METABOLIC & TRACER STUDIES

The deuterium incorporation allows researchers to track the transformation of quinoline-based molecules in:

• Microbial metabolism

• Hepatic enzymatic pathways

• Environmental degradation studies

The mass difference enables clear discrimination between endogenous metabolites and the labeled tracer.

3. PHARMACEUTICAL RESEARCH

Quinaldic-d6 Acid is essential in:

• Drug impurity profiling

• Metabolite identification

• Stability testing

• Process chemistry monitoring

Its use helps confirm reaction intermediates, monitor degradation, and validate synthetic routes involving quinoline carboxylates.

4. ISOTOPE-DILUTION MASS SPECTROMETRY (IDMS)

Due to its high isotopic purity and non-exchangeable labeling, Quinaldic-d6 Acid is highly reliable for:

• Quantitative standards

• Calibration curves

• Reference method development

5. ENVIRONMENTAL & TOXICOLOGICAL ANALYSIS

Quinaldic derivatives appear in:

• Microbial transformation of tryptophan

• Environmental breakdown of aromatic compounds

• Chemical exposure pathways

Quinaldic-d6 Acid assists in sensitive detection and quantification across environmental matrices.

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SCIENTIFIC SIGNIFICANCE

Stable-isotope-labeled compounds like Quinaldic-d6 Acid are indispensable in modern analytical science. Their ability to correct for variability and improve accuracy is crucial in regulated and research environments. The quinoline backbone also makes this compound a key tool in studying heterocyclic aromatic chemistry, photodegradation, and bioactivation pathways.

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CONCLUSION

Quinaldic-d6 Acid (CAS 1219802-18-2) is a robust, high-purity deuterium-labeled standard that enables accurate measurement, tracing, and characterization of quinoline-based compounds. Its stability, non-exchangeable labeling, and analytical precision make it a valuable asset for LC-MS/MS quantification, pharmacokinetic studies, impurity profiling, and environmental research. Whether used for routine analytical testing or specialized metabolic investigations, it supports high-confidence, reproducible scientific outcomes.

 

 

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