Ractopamine-d3 HCl | CAS 1219794-72-5

OVERVIEW  of  Ractopamine-d3 HCl | CAS 1219794-72-5

Ractopamine-d₃ HCl (CAS 1219794-72-5) is a stable isotope-labeled analog of ractopamine hydrochloride, a β-adrenergic receptor agonist widely used in veterinary medicine and livestock feed to promote lean muscle growth and improve feed efficiency. In this deuterated variant, three hydrogen atoms are replaced by deuterium, introducing a +3 Da molecular mass shift while preserving the original chemical and pharmacological behavior of ractopamine.

Ractopamine-d₃ HCl serves as an essential internal standard for LC-MS/MS and GC-MS methods, providing precise and reproducible quantification of ractopamine residues in biological and food matrices. It is commonly employed in food safety monitoring, pharmacokinetic research, and regulatory residue testing to ensure compliance with international safety limits and analytical accuracy.

CHEMICAL INFORMATION

• Name: Ractopamine-d₃ hydrochloride

• Molecular Formula: C₁₁H₁₆D₃NO₃·HCl

• Molecular Weight: 292.87 g/mol

• CAS Number: 1219794-72-5

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated β-adrenergic agonist; stable isotope-labeled veterinary drug

• Stability: Stable under recommended storage and handling conditions

APPLICATIONS  of  Ractopamine-d3 HCl | CAS 1219794-72-5

• Residue Quantification in Food Safety Testing:
  Ractopamine-d₃ HCl is used as a stable isotope-labeled internal standard for quantifying trace levels of ractopamine residues in meat, feed, milk, and tissue samples, ensuring regulatory compliance with food safety standards.

• Pharmacokinetic and Metabolic Research:
  Applied in ADME (absorption, distribution, metabolism, and excretion) studies of ractopamine in animal models to determine dosage, bioavailability, and residue clearance times.

• Veterinary Drug Analysis:
  Enables accurate and reproducible LC-MS/MS quantification of ractopamine in veterinary formulations and biological samples such as plasma, serum, and urine.

• Forensic and Doping Control:
  Supports anti-doping investigations and veterinary surveillance programs by confirming or ruling out illicit β-agonist administration.

• Analytical Method Development and Validation:
  Used as a calibration and quality control reference to standardize ractopamine detection assays, improving analytical precision and reproducibility.

ADVANTAGES  of  Ractopamine-d3 HCl | CAS 1219794-72-5

• High isotopic enrichment (≥ 98 atom % D) ensures distinct mass separation from unlabeled ractopamine.

• Chemically identical to the native compound, guaranteeing comparable chromatographic and ionization behavior.

• Non-radioactive and chemically stable, ideal for high-sensitivity mass spectrometry.

• Enhances analytical precision, reproducibility, and quantitative accuracy in complex biological matrices.

• Supports international food safety monitoring and pharmacological studies.

HANDLING, STORAGE & SAFETY

• Handling Precautions: Handle in a clean, dry environment; avoid exposure to air and light. Use gloves and safety glasses.

• Storage: Store at –20 °C in a tightly sealed, moisture-free container.

• Safety: Non-hazardous under normal laboratory conditions; handle in accordance with standard safety protocols.

• Disposal: Dispose of in accordance with institutional and governmental chemical waste disposal regulations.

QUALITY & SPECIFICATION

• Chemical Purity: ≥ 98 %

• Isotopic Enrichment: ≥ 98 atom % D

• Water Content: ≤ 0.5 %

• Form: Crystalline or lyophilized solid

• Analytical Verification: Confirmed by LC-MS and NMR spectroscopy

• Documentation: Supplied with Certificate of Analysis (CoA) verifying purity, isotopic composition, and stability

SUMMARY
Ractopamine-d₃ HCl | CAS 1219794-72-5 is a deuterated reference standard developed for quantitative determination of ractopamine in regulatory, pharmacological, and food safety studies. Its isotopic labeling allows clear mass differentiation in LC-MS/MS assays while maintaining identical analytical characteristics to the parent compound. With high isotopic enrichment and stability, Ractopamine-d₃ HCl ensures analytical precision and compliance in testing laboratories focused on veterinary drug residue monitoring, pharmacokinetic profiling, and quality assurance.

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