Ractopamine-d6 HCl | CAS 1276197-17-1

OVERVIEW  of  Ractopamine-d6 HCl | CAS 1276197-17-1

Ractopamine-d₆ HCl (CAS 1276197-17-1) is a stable isotope-labeled analog of ractopamine hydrochloride, a β-adrenergic agonist widely used as a feed additive to enhance lean muscle growth in livestock such as pigs and cattle. In this deuterated form, six hydrogen atoms of the parent molecule are replaced with deuterium, introducing a +6 Da molecular mass difference while retaining the same chemical, chromatographic, and biological properties as ractopamine.

This isotopically labeled compound is primarily used as an internal standard in LC-MS/MS and GC-MS assays to accurately quantify trace levels of ractopamine residues in biological matrices and food products. Ractopamine-d₆ HCl plays a critical role in food safety, residue monitoring, pharmacokinetics, and regulatory compliance testing, ensuring precise analytical validation and reliable detection results.

CHEMICAL INFORMATION

• Name: Ractopamine-d₆ hydrochloride

• Molecular Formula: C₁₁H₁₃D₆NO₃·HCl

• Molecular Weight: 292.87 g/mol

• CAS Number: 1276197-17-1

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated β-adrenergic agonist; stable isotope-labeled veterinary drug standard

• Stability: Chemically and isotopically stable under recommended conditions

APPLICATIONS  of  Ractopamine-d6 HCl | CAS 1276197-17-1

• Analytical and Bioanalytical Quantification:
  Used as a stable isotope-labeled internal standard in LC-MS/MS assays for quantitative detection of ractopamine residues in meat, feed, urine, plasma, and tissue samples.

• Food Safety and Regulatory Compliance:
  Essential for monitoring ractopamine residues in animal-derived food products, supporting compliance with global safety standards set by FDA, EFSA, CFIA, and Codex Alimentarius.

• Pharmacokinetic and Metabolic Studies:
  Applied in research on the absorption, metabolism, and elimination of β-adrenergic agonists in livestock to ensure safe withdrawal periods and residue control.

• Forensic and Doping Analysis:
  Utilized for anti-doping investigations and veterinary drug surveillance, helping confirm or rule out illicit β-agonist use in animals or athletes.

• Mass Spectrometry Calibration:
  Serves as a reference standard for retention time, mass calibration, and signal normalization in LC-MS/MS methods, ensuring analytical precision.

ADVANTAGES  of  Ractopamine-d6 HCl | CAS 1276197-17-1

• High isotopic enrichment (≥ 98 atom % D) ensures distinct mass separation from unlabeled ractopamine.

• Identical chromatographic and ionization behavior allows accurate internal standardization.

• Non-radioactive, stable, and compatible with all major analytical detection platforms.

• Improves quantification accuracy, reproducibility, and inter-laboratory consistency.

• Facilitates compliance with international residue monitoring regulations.

HANDLING, STORAGE & SAFETY

• Handling Precautions: Avoid prolonged exposure to air, moisture, and direct sunlight. Use gloves and protective equipment while handling.

• Storage: Store at –20 °C in a sealed, dry container, protected from light.

• Safety: Non-hazardous and non-radioactive. Handle under standard laboratory safety protocols.

• Disposal: Dispose of according to institutional and local chemical waste guidelines.

QUALITY & SPECIFICATION

• Chemical Purity: ≥ 98 %

• Isotopic Enrichment: ≥ 98 atom % D

• Water Content: ≤ 0.5 %

• Form: Crystalline or lyophilized solid

• Analytical Verification: Confirmed by LC-MS and NMR spectroscopy

• Documentation: Supplied with Certificate of Analysis (CoA) confirming purity, isotopic enrichment, and analytical consistency

SUMMARY
Ractopamine-d₆ HCl | CAS 1276197-17-1 is a high-purity deuterated reference standard designed for quantitative residue analysis and pharmacokinetic studies. Its isotopic labeling makes it an indispensable tool for mass spectrometric detection of ractopamine in regulatory, food safety, and forensic testing laboratories. Offering excellent isotopic enrichment and chemical stability, Ractopamine-d₆ HCl ensures accuracy, reproducibility, and traceability in modern LC-MS/MS workflows aimed at monitoring veterinary drug residues and ensuring compliance with international food safety standards.

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