Sodium propionate-d5 | CAS 202529-18-8

OVERVIEW  of  Sodium propionate-d5 | CAS 202529-18-8

Sodium propionate-d₅ (CAS 202529-18-8) is a deuterium-labeled analog of sodium propionate (C₃H₅NaO₂), in which five hydrogen atoms are replaced by deuterium. This isotopic substitution offers a predictable molecular mass shift while retaining the same physicochemical and biological properties as the unlabeled compound. Due to its high isotopic enrichment and stability, Sodium propionate-d₅ is widely employed as an internal standard, metabolic tracer, and quantitative reference material in analytical, biochemical, and environmental studies.

As the sodium salt of a short-chain fatty acid, Sodium propionate-d₅ plays a central role in studies of microbial fermentation, metabolic profiling, and food chemistry. Its high deuterium enrichment makes it particularly useful for LC-MS and GC-MS quantification, allowing researchers to achieve precise differentiation between labeled and unlabeled propionate in complex biological and environmental samples.

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CHEMICAL INFORMATION

• Chemical Name: Sodium propionate-d₅

• Synonyms: Propanoic acid-d₅ sodium salt; Sodium propanoate-d₅

• CAS Number: 202529-18-8

• Molecular Formula: C₃D₅NaO₂

• Molecular Weight: 101.09 g/mol

• Isotopic Enrichment: ≥98 atom % D

• Stability: Stable under normal temperature and pressure

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APPLICATIONS  of  Sodium propionate-d5 | CAS 202529-18-8

1. Mass Spectrometry Internal Standard
Sodium propionate-d₅ serves as a stable isotope-labeled internal standard for the quantification of propionic acid and its derivatives in biological fluids, fermentation broths, and environmental samples. Its identical chromatographic behavior and predictable mass shift make it ideal for accurate calibration and quantitative trace analysis in GC-MS and LC-MS workflows.

2. Metabolomic and Microbial Studies
This compound is extensively used in gut microbiome and metabolomic investigations to trace propionate production, uptake, and utilization pathways. As a naturally occurring short-chain fatty acid (SCFA) metabolite, propionate plays a critical role in host energy metabolism and signaling, making the deuterated form indispensable for isotope tracing in physiological systems.

3. Food and Fermentation Research
Sodium propionate-d₅ is a valuable analytical standard for determining preservative content, volatile fatty acids, and fermentation products in food and beverage analysis. It enables accurate measurement of propionate levels in cheese, baked goods, and fermented products.

4. Clinical and Pharmacokinetic Studies
Used in biomedical research, Sodium propionate-d₅ aids in the assessment of propionate metabolism and absorption in the human body. It helps evaluate propionate’s influence on lipid metabolism, glucose regulation, and gut–brain axis signaling.

5. Environmental and Chemical Tracing
Its deuterium label allows for the tracking of propionate transformations in soil and aquatic ecosystems. This makes it useful in bioremediation studies, carbon cycle research, and stable isotope probing experiments.

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ADVANTAGES  of  Sodium propionate-d5 | CAS 202529-18-8

• High Isotopic Purity (≥98 atom % D): Ensures clear mass distinction and analytical accuracy.

• Chemically Stable: Non-volatile and easily handled in routine analytical conditions.

• Excellent Solubility: Readily dissolves in water for reproducible sample preparation.

• Non-Radioactive Label: Safe for laboratory use with no radiological handling requirements.

• Ideal for Quantitative and Metabolic Studies: Provides consistency and reliability in isotope-based analyses.

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RESEARCH SIGNIFICANCE
Sodium propionate-d₅ plays an important role in modern metabolomics, biochemistry, and microbial ecology research. Propionate is one of the three key SCFAs produced during the anaerobic fermentation of dietary fibers by gut microbiota. Its physiological roles include modulating lipid metabolism, regulating glucose homeostasis, and influencing appetite control via signaling through G-protein coupled receptors (GPCRs).

Using Sodium propionate-d₅, researchers can perform isotopic flux studies to quantify the formation and turnover rates of propionate in complex biological systems. This isotopically labeled compound allows the differentiation of endogenous versus exogenous sources and helps elucidate propionate’s role in metabolic health and disease. Furthermore, in environmental chemistry, it assists in tracing the fate and biodegradation of carboxylate compounds, supporting sustainable biotechnological and ecological applications.

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SUMMARY
Sodium propionate-d₅ (CAS 202529-18-8) is a high-purity, deuterium-labeled salt designed for use as a stable isotope-labeled standard in mass spectrometry, metabolomics, and food analysis. With ≥98 atom % deuterium enrichment, it ensures exceptional analytical precision, reproducibility, and traceability in isotope-based quantitative studies.

At ResolveMass Laboratories Inc., Sodium propionate-d₅ is manufactured under stringent quality control standards to guarantee isotopic enrichment, purity, and stability. Its versatility and reliability make it an indispensable compound for scientists engaged in metabolomic research, gut microbiome studies, nutritional biochemistry, and environmental analysis.

 

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