Styrene-d8 | CAS 19361-62-7

OVERVIEW
Styrene-d8 | CAS 19361-62-7 is a deuterated analog of styrene in which eight hydrogen atoms are replaced with deuterium. This isotopically labeled compound is primarily used as an internal standard in analytical chemistry, particularly for quantitative mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy applications. The incorporation of deuterium into the molecule provides distinct mass differences while retaining chemical behavior similar to non-deuterated styrene, enabling highly accurate analytical measurements.

Styrene-d8 is widely utilized in laboratories focusing on environmental analysis, polymer research, and organic synthesis, where precise quantification of styrene and related compounds is required. Its chemical stability, high purity, and isotopic enrichment make it an essential tool for both routine and advanced analytical applications.

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CHEMICAL INFORMATION

• Chemical Name: Styrene-d8

• CAS Number: 19361-62-7

• Molecular Formula: C8D8

• Molecular Weight: 112.11 g/mol

• Chemical Structure: C6D5–CD=CD2

• Purity: ≥98% isotopic enrichment typical

• Deuterium Content: Eight deuterium atoms per molecule

Styrene-d8 retains the aromatic vinyl structure of regular styrene, ensuring that its reactivity closely mirrors the parent compound. The substitution of hydrogen with deuterium minimally impacts the chemical behavior while providing a significant mass shift for analytical differentiation.

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APPLICATIONS  of  Styrene-d8 | CAS 19361-62-7

1. Internal Standard for Mass Spectrometry
   Styrene-d8 is widely used as an internal standard in GC-MS (Gas Chromatography-Mass Spectrometry) and LC-MS (Liquid Chromatography-Mass Spectrometry) methods. By providing a reference compound with similar chemical properties but distinguishable mass, Styrene-d8 enables highly precise quantification of styrene and its derivatives in complex samples such as environmental matrices, food, and polymer extracts.

2. NMR Spectroscopy
   Due to its deuterated nature, Styrene-d8 is also valuable in NMR spectroscopy. The deuterium atoms reduce signal interference from hydrogen in proton NMR experiments, improving spectral resolution and simplifying analysis in both organic synthesis studies and polymer characterization.

3. Environmental and Industrial Analysis
   Styrene is a common volatile organic compound (VOC) found in industrial emissions, consumer products, and polymer manufacturing processes. Styrene-d8 serves as a reliable standard for monitoring and quantifying trace levels of styrene in air, water, and soil samples, supporting environmental compliance and regulatory testing.

4. Polymer Research and Material Science
   In polymer chemistry, Styrene-d8 is used to study polymerization kinetics, chain propagation, and styrene-based copolymer properties. The isotopic labeling facilitates mechanistic investigations and provides insights into reaction pathways, degradation processes, and structural elucidation.

5. Analytical Method Development
   Laboratories developing GC-MS or LC-MS methods for VOC detection frequently use Styrene-d8 to calibrate instruments, validate analytical procedures, and assess matrix effects. Its chemical similarity to styrene ensures that extraction, separation, and detection conditions closely mimic real samples.

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SAFETY AND HANDLING
Styrene-d8 should be handled with the same care as conventional styrene. It is a flammable liquid and may pose health hazards upon inhalation, ingestion, or skin contact. Standard laboratory safety protocols, including the use of gloves, protective eyewear, and working in a fume hood, are strongly recommended. Storage should be in a cool, dry place away from sources of ignition.

KEY FEATURES

• High deuterium enrichment for accurate isotopic labeling

• Excellent chemical stability and purity

• Ideal for GC-MS, LC-MS, and NMR applications

• Supports environmental, industrial, and polymer analysis

• Reliable internal standard for quantitative studies

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CONCLUSION
Styrene-d8 (CAS 19361-62-7) is an indispensable tool in modern analytical and polymer chemistry. Its deuterated structure ensures accurate quantification, reliable internal standardization, and improved spectral clarity in NMR experiments. ResolveMass Laboratories Inc. provides high-purity Styrene-d8 suitable for a wide range of applications, including environmental monitoring, method development, and polymer research. With its consistent quality and isotopic enrichment, Styrene-d8 enables researchers to achieve precise, reproducible results across diverse analytical platforms.

 

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