Ticagrelor-d7 | CAS 1265911-55-4

At ResolveMass Laboratories Inc., we supply premium-quality isotope-labeled reference standards to support pharmaceutical research, bioanalytical method development, therapeutic drug monitoring, clinical pharmacology, and regulatory submissions. Our analytical expertise enables researchers and pharmaceutical companies to achieve robust, reproducible, and regulatory-compliant quantitative results throughout drug development.

Product Overview

Ticagrelor is a direct-acting, reversible P2Y12 receptor antagonist widely prescribed as an antiplatelet agent for reducing thrombotic cardiovascular events in patients with acute coronary syndrome (ACS) and related cardiovascular conditions. Accurate measurement of ticagrelor concentrations in plasma, serum, and other biological matrices is critical during pharmacokinetic (PK), bioavailability (BA), bioequivalence (BE), drug-drug interaction (DDI), and clinical research studies.

Applications

Ticagrelor-d7 is widely used in pharmaceutical, clinical, and analytical laboratories for numerous applications, including:

• LC-MS/MS quantitative analysis of ticagrelor
• LC-HRMS method development and validation
• Pharmacokinetic and toxicokinetic studies
• Bioavailability and bioequivalence studies
• Clinical therapeutic drug monitoring
• Metabolism and disposition studies
• Drug-drug interaction investigations
• Bioanalytical assay validation following regulatory guidelines
• Pharmaceutical quality control and analytical research
• Stable isotope dilution mass spectrometry (SIDMS)

Its excellent analytical performance makes it suitable for both preclinical and clinical bioanalysis where highly sensitive and reproducible quantification is essential.

Advantages of Using Ticagrelor-d7

Using an isotopically labeled internal standard provides several analytical advantages over structural analogues:

• Corrects for matrix-induced ion suppression or enhancement
• Compensates for sample preparation and extraction variability
• Improves precision and analytical reproducibility
• Reduces instrument-to-instrument variation
• Enhances assay sensitivity and quantitative accuracy
• Supports regulatory-compliant LC-MS/MS method validation
• Produces reliable pharmacokinetic and bioequivalence data
• Ideal for high-throughput bioanalytical workflows

Because Ticagrelor-d7 co-elutes with the unlabeled analyte while remaining distinguishable by mass spectrometry, it provides exceptional correction for analytical variability throughout the entire workflow.

Typical Analytical Techniques

ResolveMass Laboratories supports analytical workflows involving Ticagrelor-d7 using advanced instrumentation, including:

• Triple Quadrupole LC-MS/MS
• High-Resolution LC-MS (Orbitrap and QTOF platforms)
• UHPLC-MS/MS
• Stable Isotope Dilution Mass Spectrometry
• Bioanalytical Method Validation
• Clinical Sample Quantification
• Pharmacokinetic Sample Analysis

Our experienced scientists develop and validate sensitive analytical methods capable of detecting trace concentrations while meeting global regulatory expectations.

Product Characteristics

Ticagrelor-d7 is supplied as a high-purity stable isotope-labeled analytical reference standard intended exclusively for laboratory research applications. Typical product characteristics include:

• CAS Number: 1265911-55-4
• Molecular Formula: C₂₃H₂₁D₇F₂N₆O₄S
• Molecular Weight: 529.61 g/mol
• Stable Isotope: Deuterium (²H₇)
• Analytical Use: Internal standard for LC-MS/MS quantification
• Research Use Only: Not intended for human or veterinary therapeutic use.

Batch-specific Certificates of Analysis (CoA) typically provide purity, isotopic enrichment, and analytical characterization data to ensure traceability and confidence in quantitative applications.

Importance in Regulated Bioanalysis

Modern bioanalytical laboratories increasingly rely on isotope-labeled internal standards to satisfy regulatory expectations established by agencies such as the FDA, EMA, and ICH. During bioanalytical method validation, the use of a stable isotope-labeled analogue minimizes analytical bias and improves assay robustness across multiple validation parameters, including:

• Accuracy
• Precision
• Recovery
• Matrix effect
• Stability
• Selectivity
• Carryover
• Dilution integrity

The use of Ticagrelor-d7 helps laboratories generate high-quality quantitative data suitable for regulatory submissions, clinical studies, and pharmaceutical product development.

Why Choose ResolveMass Laboratories Inc.?

ResolveMass Laboratories Inc. is a trusted analytical partner supporting pharmaceutical innovators, generic manufacturers, biotechnology companies, CROs, and academic researchers. Our expertise spans stable isotope-labeled reference standards, impurity characterization, LC-MS/MS method development, pharmacokinetic bioanalysis, and advanced mass spectrometry.

By combining scientific expertise with state-of-the-art instrumentation, we help clients accelerate analytical method development while maintaining the highest standards of quality, reproducibility, and regulatory compliance. Whether supporting early-stage research or late-phase clinical programs, our team delivers dependable analytical solutions tailored to complex pharmaceutical applications.