Trimethyl-d9-acetic Acid | CAS 42983-07-3

OVERVIEW  of  Trimethyl-d9-acetic Acid | CAS 42983-07-3

Trimethyl-d₉-acetic acid is a fully deuterated isotopologue of trimethylacetic acid (pivalic acid), where all nine hydrogen atoms of the three methyl groups are replaced with deuterium. This high isotopic enrichment produces a clear and measurable mass shift, making the compound highly valuable in a wide range of analytical, environmental, and research applications.

Because of its compact structure, strong steric hindrance, and excellent thermal stability, Trimethyl-d₉-acetic acid is frequently used as an internal standard for GC-MS and LC-MS quantification, particularly in studies involving volatile fatty acids, branched carboxylic acids, and industrial chemicals. Its deuterated form enables precise calibration, supports isotope dilution methodologies, and enhances the accuracy of trace-level analysis in complex matrices.

---

CHEMICAL INFORMATION

• Name : Trimethyl-d₉-acetic acid

• CAS Number: 42983-07-3

• Molecular Formula: C₅D₉O₂

• Molecular Weight: 111.199 g/mol

• Isotopic Enrichment: ≥98% D

• Chemical Class: Deuterated branched short-chain fatty acid

• Stability: Resistant to oxidation and thermal decomposition due to sterically hindered tertiary carbon structure

---

APPLICATIONS  of  Trimethyl-d9-acetic Acid | CAS 42983-07-3
Trimethyl-d₉-acetic acid is widely used in analytical and research environments where stable isotope-labeled carboxylic acids provide essential calibration accuracy, mechanistic insight, and structural clarity:

• Internal Standard for GC-MS and LC-MS:
  Ideal for quantifying pivalic acid or related branched carboxylic acids, volatile fatty acids, and industrial intermediates across biological, environmental, and chemical samples.

• Isotope Dilution Mass Spectrometry (IDMS):
  Supports high-precision quantification with excellent reproducibility due to strong mass separation from the non-labeled analogue.

• Environmental Monitoring:
  Useful for tracking carboxylic acids in atmospheric, soil, water, and industrial emissions studies, especially in complex or low-concentration samples.

• Metabolomic and Biochemical Studies:
  Assists in tracing metabolic pathways involving branched acids, fatty acid degradation, or microbial transformations.

• Degradation and Stability Testing:
  Employed to study oxidation, fragmentation, or catalytic breakdown of branched hydrocarbons or carboxylic acids.

• Industrial Chemical and Polymer Research:
  Provides reference profiling for chemicals related to lubricants, plastic additives, and synthetic intermediates.

• Reaction Mechanism Studies:
  Extensively used in isotope-effect investigations to understand proton transfer, substitution pathways, and steric influences on reaction kinetics.

---

ADVANTAGES  of  Trimethyl-d9-acetic Acid | CAS 42983-07-3

• High Deuterium Incorporation (9 D):
  Offers a substantial and clear mass shift ideal for mass spectrometry with minimal interference.

• Excellent Thermal and Chemical Stability:
  The tertiary carbon center of pivalic acid ensures robustness, making it suitable for high-temperature GC applications.

• Low Susceptibility to Isotopic Exchange:
  Strong C–D bonds and shielded methyl groups significantly reduce risk of deuterium scrambling.

• Reliable Internal Standard:
  Chemically similar to the non-labeled acid while remaining analytically distinct, ensuring accurate quantification across matrices.

• Versatile Across Analytical Techniques:
  Works seamlessly with GC-MS, LC-MS, FT-IR, NMR, and environmental testing workflows.

• Broad Industrial Relevance:
  Useful in petrochemical research, biotechnology, materials science, environmental assessment, and quality control laboratories.

---

SUMMARY
Trimethyl-d₉-acetic acid (CAS 42983-07-3) is a highly stable, fully deuterated fatty acid designed for analytical accuracy and advanced research needs. Its nine deuterium atoms provide a well-defined mass shift, making it an ideal internal standard for MS-based quantification, environmental analyses, and organic reaction studies. The molecule’s steric stability, minimal isotopic exchange, and wide method compatibility allow laboratories to achieve high-precision results across diverse applications. Whether used in calibration, isotopic tracing, or mechanistic investigation, Trimethyl-d₉-acetic acid is a reliable, high-performance tool for modern analytical science.

 

Learn more about,

Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends

Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 

ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States. 

Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 

How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 

How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 

Deuterium-Labelled Compounds — Synthesis, Applications & Ordering 

Custom Synthesis of Deuterated Chemicals