mPEG-PLA

mPEG-PLA (Methoxy poly(ethylene glycol)-b-poly(lactic acid)) – Biodegradable Amphiphilic Block Copolymers for Advanced Drug Delivery

ResolveMass Laboratories Inc. offers high-purity mPEG-PLA block copolymers engineered for use in nanoparticles, micelles, long-acting formulations, and complex generic drug delivery systems. This AB block copolymer contains a hydrophilic mPEG block covalently attached to a hydrophobic PLA block, enabling the formation of stable nano-assemblies ideal for encapsulating both hydrophobic and hydrophilic APIs.

mPEG-PLA is widely used in solubility enhancement, controlled-release formulation, and parenteral drug delivery because of its biodegradability, excellent safety profile, and predictable degradation to PEG, lactic acid, and CO₂.

Key Features & Technical Advantages
1. Amphiphilic Architecture for Nanoparticle Formation

The hydrophobic PLA segment forms a core while the mPEG segment forms a stabilizing corona. This enables:

Self-assembly into micelles (10–200 nm)

Minimal aggregation due to PEG shielding

High encapsulation efficiency for hydrophobic APIs

Improved circulation time in vivo

2. Tunable PLA Block Length for Controlled Release

We offer customizable molecular weight ranges to precisely tune:

Drug release kinetics

Polymer degradation rate

Hydrophilic–hydrophobic balance

Nanoparticle stability and size

Available PLA block MW: 2–200 kDa
Available mPEG block MW: 1–20 kDa

3. High Purity & Advanced Analytical Characterization

Every lot is characterized with:

GPC/SEC with universal calibration for accurate Mn and PDI

¹H/¹³C NMR for block ratio determination

FTIR for polymer identity confirmation

MALDI-TOF or HRMS (optional) for end-group verification

DSC/TGA (optional) for studying thermal behavior

These QC data ensure suitability for CMC-driven formulation, complex generics, and NDA enabling R&D.

Applications
✔ Polymeric Micelles for Solubility Enhancement

mPEG-PLA forms nanoscale micelles that significantly increase aqueous solubility of poorly soluble drugs.

Ideal for:

Oncology APIs

Immunomodulators

Lipophilic small molecules

✔ Nanoparticle Drug Delivery Systems

Provides stable nanoparticles with:

Low polydispersity

Controlled size

Reduced opsonization

Enhanced circulation time

✔ Sustained and Controlled Release Formulations

PLA block degradability allows release windows from days to weeks, suitable for:

Injectable depot systems

Implantable formulations

Ophthalmic sustained-release platforms

✔ Custom Polymer Design for Pharma R&D

ResolveMass Laboratories supports tailor-made block copolymers for:

Precision drug delivery

Peptide/biologic stabilization

High drug loading systems

Early-stage formulation screening

Why Choose ResolveMass Laboratories Inc.?
✔ Expertise in PEG-Based Biodegradable Block Copolymers

We specialize in:

mPEG-PLA

mPEG-PLGA

PLA-PEG-PLA

PCL-PEG-PCL

Fully customized polymer systems

✔ Advanced Polymer QC and Analytical Capabilities

Our infrastructure includes:

High-field NMR

Triple-detector GPC

HRMS & LC-MS/MS

Thermal analysis (DSC/TGA)

FTIR spectroscopic profiling

✔ Formulation-Oriented Polymer Engineering

Designed specifically for:

Complex generic injectables

Long-acting formulations

Novel drug delivery systems

Polymer screening for CMC and preclinical development

Available Grades

Research grade

High-purity formulation development grade

Custom-synthesized blocks with specific MW/ratios

Request Custom mPEG-PLA Specifications

If you need a precise mPEG block, PLA molecular weight, polymer ratio, or terminal group configuration, our chemistry team can synthesize the exact polymer required for your project.