1-Aminoadamantane-d15 | CAS 33830-10-3

OVERVIEW
1-Aminoadamantane-d15 | CAS 33830-10-3 is a fully deuterated analog of 1-aminoadamantane, a rigid tricyclic amine structure widely used in pharmaceutical development, metabolite research, and high-precision analytical studies. Incorporating fifteen deuterium atoms into the adamantane backbone enhances its utility as an internal standard for mass spectrometry, enabling improved quantification accuracy, reduced background noise, and enhanced stability. As deuterated biomarkers and reference standards continue to gain traction in bioanalytical workflows, 1-Aminoadamantane-d15 serves as a reliable and high-purity isotope-labeled compound for advanced R&D and regulated applications.

This compound is especially valuable in laboratories working on antiviral research, neuropharmacology studies, dissolution profiling, ADME characterization, and small-molecule bioanalysis. Its stable isotopic labeling allows researchers to distinguish the molecule from endogenous or non-labeled forms during LC–MS, GC–MS, or NMR analysis.

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CHEMICAL INFORMATION
• Chemical Name: 1-Aminoadamantane-d15
• CAS Number: 33830-10-3
• Molecular Formula: C10D15N
• Molecular Weight:  116.23 g/mol
• Structure: Adamantane cage structure with an amino group at the 1-position
• Isotopic Labeling: Fully deuterated on all 15 adamantane hydrogens
• Synonyms:
 – Amantadine-d15
 – 1-Amino-tricyclo[3.3.1.1³,⁷]decane-d15
 – Adamantan-1-amine-d15
 – Deuterated Amantadine
• Physical Properties (typical):
 – Appearance: White to off-white crystalline solid
 – Solubility: Soluble in water, alcohols, and polar organic solvents
 – Stability: Highly stable owing to the rigid cage-like adamantane scaffold

The adamantane core provides exceptional thermal, chemical, and oxidative stability. When combined with deuterium labeling, the molecule becomes highly resistant to isotopic exchange under standard laboratory conditions, resulting in consistent analytical performance.

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FEATURES & ADVANTAGES

High Isotopic Purity
1-Aminoadamantane-d15 is synthesized using controlled deuterium incorporation methods to ensure excellent isotopic enrichment (>98% D), making it ideal for quantitative applications.

Superior Analytical Performance
The deuterated backbone produces a distinct mass shift in high-resolution mass spectrometry, helping analysts differentiate the compound from endogenous amantadine or synthetic intermediates.

Outstanding Stability
The adamantane structure is known for its rigidity and resistance to metabolic degradation. This makes the deuterated analog highly robust during sample preparation, extraction, and storage.

Versatile Compatibility
Suitable for LC–MS, GC–MS, NMR, metabolic pathway investigations, and bioanalytical method development.

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APPLICATIONS  of  1-Aminoadamantane-d15 | CAS 33830-10-3

1. INTERNAL STANDARD FOR LC–MS/MS AND GC–MS
1-Aminoadamantane-d15 is frequently used as an internal standard in bioanalytical assays quantifying non-deuterated 1-aminoadamantane or related compounds. The mass shift provided by deuteration allows direct tracking of recovery efficiency, matrix effects, and sample stability, resulting in highly validated quantitative methods.

2. DRUG METABOLISM AND PHARMACOKINETIC STUDIES
Its structural alignment with amantadine makes it ideal for ADME and PK studies. When paired with biological matrices, deuterated internal standards help improve data calibration, accuracy, and reproducibility, especially in clinical research environments.

3. REFERENCE STANDARD FOR NMR ANALYSIS
The deuterium atoms contribute to improved signal resolution and reduced proton background, allowing researchers to obtain clean spectra and evaluate structural or conformational features with precision.

4. RESEARCH ON ADAMANTANE-BASED PHARMACEUTICALS
Adamantane derivatives serve roles in antiviral therapies, neuroprotective strategies, and NMDA receptor modulation. 1-Aminoadamantane-d15 is therefore an important reference compound for medicinal chemistry, mechanistic toxicology, impurity profiling, and synthetic pathway optimization.

5. MATERIALS AND POLYMER RESEARCH
Adamantane scaffolds exhibit unique steric and electronic behavior that researchers leverage when developing high-performance materials. A deuterated analog enables kinetic isotope studies to investigate reaction pathways, thermal degradation profiles, and polymer interactions.

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QUALITY & COMPLIANCE
ResolveMass Laboratories Inc. ensures that all isotope-labeled compounds, including 1-Aminoadamantane-d15, meet stringent quality benchmarks. Each batch undergoes rigorous QC testing, including:
• Identity confirmation via ¹H/²H NMR
• Purity assessment by LC–MS and GC–MS
• Isotopic enrichment verification
• Residual solvent and impurity profiling

Our manufacturing and testing practices support both research-grade and regulated-study requirements, making our deuterated standards suitable for pharmaceutical, academic, and industrial workflows.

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