1,16-Hexadecanedioic-d28-Acid | CAS 130348-90-2

OVERVIEW  of  1,16-Hexadecanedioic-d28-Acid | CAS 130348-90-2

1,16-Hexadecanedioic-d₂₈ acid (CAS 130348-90-2) is a fully deuterated long-chain α,ω-dicarboxylic acid, serving as the isotopically labeled analog of hexadecanedioic acid. With 28 deuterium atoms replacing nearly all hydrogen atoms, it provides enhanced mass differentiation and stability in metabolic, lipidomic, and analytical studies. This compound is highly valued in mass spectrometry (MS) and stable isotope tracing for precise quantitative and mechanistic research.

CHEMICAL INFORMATION

• Name: 1,16-Hexadecanedioic-d₂₈ acid

• Molecular Formula: C₁₆D₂₈O₄

• Molecular Weight: 314.58 g/mol

• CAS Number: 130348-90-2

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated dicarboxylic acid

• Solubility: Slightly soluble in water; soluble in ethanol, methanol, and organic solvents (e.g., chloroform)

APPLICATIONS  of  1,16-Hexadecanedioic-d28-Acid | CAS 130348-90-2

• Mass Spectrometry (MS) Internal Standard:
  Utilized as a reference compound in GC-MS and LC-MS methods for quantification of long-chain dicarboxylic acids and lipid metabolites, providing precise isotope ratio comparison.

• Stable Isotope Labeling:
  Applied in metabolic flux analysis and lipid oxidation pathway studies, aiding in tracking fatty acid degradation and biosynthesis.

• Biochemical & Pharmaceutical Research:
  Used to investigate fatty acid metabolism, peroxisomal β-oxidation, and related enzymatic processes.

• Analytical Calibration:
  Serves as a calibration or recovery standard in quantitative assays involving carboxylic acids or fatty acid derivatives.

• Environmental and Chemical Tracing:
  Acts as a stable tracer in environmental fate studies of organic acids and related compounds.

ADVANTAGES  of  1,16-Hexadecanedioic-d28-Acid | CAS 130348-90-2

• High isotopic purity ensures analytical accuracy and reproducibility.

• Chemically stable under standard laboratory conditions.

• Distinct mass spectral signature minimizes interference with native compounds.

• Suitable for use in both research-grade and GLP-compliant analytical workflows.

HANDLING AND SAFETY

• Handling Precautions: Avoid inhalation and contact with eyes or skin; use standard laboratory protective measures.

• Protective Equipment: Gloves, lab coat, and safety glasses recommended.

• Storage: Keep tightly sealed in a cool, dry location away from oxidizing agents.

• Stability: Stable under normal conditions; avoid excessive heat and moisture.

• Disposal: Dispose according to local environmental and chemical safety regulations.

SUMMARY
1,16-Hexadecanedioic-d₂₈ acid (CAS 130348-90-2) is a fully deuterated α,ω-dicarboxylic acid designed for high-precision isotope-labeled analysis in biochemical, pharmaceutical, and environmental research. Its high deuterium enrichment, chemical stability, and compatibility with modern analytical techniques make it a preferred internal standard for quantifying and tracing long-chain dicarboxylic acids in complex systems.