1,4-Dichlorobenzene-d4 | CAS 3855-82-1

1,4-Dichlorobenzene-d4 | CAS 3855-82-1 is a stable isotope-labeled analog of 1,4-dichlorobenzene in which four hydrogen atoms are replaced with deuterium (^2H or D). This isotopically enriched compound exhibits nearly identical chemical and physical properties to the non-labeled parent compound while being distinguishable by its increased molecular mass during mass spectrometric analysis. As a result, it is widely employed as an internal standard, recovery standard, and calibration reference in quantitative analytical workflows involving gas chromatography-mass spectrometry (GC-MS), liquid chromatography-mass spectrometry (LC-MS), and isotope dilution mass spectrometry (IDMS).

At ResolveMass Laboratories Inc., we supply high-quality stable isotope-labeled reference materials that support accurate quantitative analysis across environmental, pharmaceutical, forensic, industrial, and research laboratories. Our 1,4-Dichlorobenzene-d4 reference standard is manufactured under stringent quality controls to ensure high isotopic enrichment, excellent chemical purity, and consistent analytical performance.

Product Information

• Product Name: 1,4-Dichlorobenzene-d4
• CAS Number: 3855-82-1
• Molecular Formula: C6D4Cl2
• Molecular Weight: 151.02 g/mol
• Isotopic Label: Deuterium (d4)
• Chemical Class: Halogenated aromatic hydrocarbon

Key Features

High Isotopic Purity

1,4-Dichlorobenzene-d4 is synthesized using advanced isotope-labeling techniques to achieve high deuterium incorporation. High isotopic purity minimizes interference from unlabeled compounds and enhances the reliability of quantitative measurements.

Excellent Chemical Purity

The material is produced with stringent purification procedures to ensure low impurity levels. High chemical purity contributes to improved reproducibility and instrument performance in sensitive analytical methods.

Ideal Internal Standard

Because its chromatographic behavior closely matches that of native 1,4-dichlorobenzene while remaining distinguishable by mass spectrometry, 1,4-Dichlorobenzene-d4 serves as an excellent internal standard for correcting sample preparation losses, extraction variability, and instrumental fluctuations.

Reliable Quantitative Analysis

The use of isotope-labeled standards significantly improves analytical accuracy by compensating for matrix effects, ion suppression, and variability during sample preparation and analysis.

Applications:

Environmental Analysis

1,4-Dichlorobenzene is recognized as an environmental contaminant that may be detected in air, water, soil, sediments, and industrial emissions. The deuterated analog is widely used as an internal standard for monitoring chlorinated aromatic compounds in environmental samples. Analytical laboratories utilize 1,4-Dichlorobenzene-d4 during routine environmental surveillance, contamination assessments, and regulatory compliance testing.

Pharmaceutical Research

Stable isotope-labeled compounds are valuable tools throughout pharmaceutical research and development. 1,4-Dichlorobenzene-d4 can be used during analytical method validation, instrument calibration, impurity profiling, and quality control procedures that require highly accurate quantification.

Forensic Toxicology

Forensic laboratories rely on isotope-labeled internal standards to obtain reliable quantitative data from complex biological and environmental matrices. The use of 1,4-Dichlorobenzene-d4 improves analytical precision while reducing variability introduced during sample preparation and instrumental analysis.

Industrial Quality Control

Manufacturers producing specialty chemicals, chlorinated intermediates, and industrial products frequently employ stable isotope-labeled standards to validate analytical methods and verify product quality. The compound assists laboratories in maintaining consistent analytical performance across routine quality assurance programs.

Academic and Research Laboratories

Universities, government laboratories, and research institutes utilize 1,4-Dichlorobenzene-d4 in analytical chemistry studies, isotope dilution experiments, environmental monitoring projects, and method development involving mass spectrometry.

Benefits of Using Stable Isotope-Labeled Standards

Stable isotope-labeled reference standards have become the preferred choice for quantitative mass spectrometric analysis because they closely mimic the behavior of native analytes throughout analytical workflows. Their use provides several important advantages:

• Improved quantitative accuracy
• Enhanced precision and reproducibility
• Compensation for extraction losses
• Correction for matrix effects
• Reduced analytical variability
• Better calibration performance
• Improved confidence in regulatory reporting
• Increased robustness of validated analytical methods

These advantages make 1,4-Dichlorobenzene-d4 an essential analytical tool for laboratories performing trace-level quantitative analysis.

Analytical Techniques

1,4-Dichlorobenzene-d4 is compatible with numerous analytical platforms, including:

• Gas Chromatography-Mass Spectrometry (GC-MS)
• Gas Chromatography-Tandem Mass Spectrometry (GC-MS/MS)
• Liquid Chromatography-Mass Spectrometry (LC-MS)
• Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
• High-Resolution Mass Spectrometry (HRMS)
• Isotope Dilution Mass Spectrometry (IDMS)

These techniques are commonly employed for sensitive detection and quantification of chlorinated aromatic compounds in complex sample matrices.

Quality Assurance

ResolveMass Laboratories Inc. maintains rigorous quality standards throughout the manufacturing and testing process. Every batch of 1,4-Dichlorobenzene-d4 undergoes comprehensive quality evaluation to verify identity, isotopic enrichment, purity, and overall performance. Detailed analytical documentation is available to support regulatory and research applications, ensuring confidence in every reference standard supplied.

Why Choose ResolveMass Laboratories Inc.?

ResolveMass Laboratories Inc. is dedicated to providing premium-quality stable isotope-labeled compounds that support laboratories worldwide. Our products are trusted by pharmaceutical companies, environmental testing laboratories, contract research organizations, academic institutions, and government agencies for demanding analytical applications.

Our commitment includes:

• High-purity stable isotope-labeled reference standards
• Reliable isotopic enrichment
• Batch-to-batch consistency
• Comprehensive quality documentation
• Expert technical support
• Fast global distribution
• Products suitable for research, method development, and routine quantitative analysis

Whether you are developing new analytical methods, validating regulatory assays, or performing routine quantitative testing, ResolveMass Laboratories Inc. offers dependable isotope-labeled standards designed to improve analytical confidence and data quality.

For additional product information, technical specifications, or customized isotope-labeled reference standards, contact the scientific team at ResolveMass Laboratories Inc. to discuss your analytical requirements.

Learn more about Deuterated Chemicals through,

• Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends
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• ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States.
• Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 
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