1,6-Hexanedioic-d8 Acid | CAS 52089-65-3

OVERVIEW of  1,6-Hexanedioic-d8 Acid | CAS 52089-65-3

1,6-Hexanedioic-d₈ acid (CAS 52089-65-3) is the fully deuterated form of adipic acid, a six-carbon α,ω-dicarboxylic acid widely used as a building block in organic and polymer chemistry. The replacement of all hydrogen atoms with deuterium provides this compound with unique isotopic characteristics, making it a valuable tool in mass spectrometry (MS), isotope dilution analysis, and metabolic studies. Owing to its high isotopic enrichment and excellent chemical stability, 1,6-Hexanedioic-d₈ acid serves as a reliable internal standard and reference material for analytical and research purposes.

CHEMICAL INFORMATION

• Name: 1,6-Hexanedioic-d₈ acid

• Molecular Formula: C₆D₈O₄

• Molecular Weight: 154.19 g/mol

• CAS Number: 52089-65-3

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated aliphatic dicarboxylic acid

• Solubility: Soluble in ethanol, methanol, and other organic solvents; sparingly soluble in water

APPLICATIONS  of  1,6-Hexanedioic-d8 Acid | CAS 52089-65-3

• Mass Spectrometry (MS) Internal Standard:
  Widely employed as an internal or calibration standard in GC-MS and LC-MS methods for the quantitative analysis of adipic acid and related metabolites in environmental and biological samples.

• Stable Isotope Labeling:
  Used in metabolic flux analysis and biochemical pathway tracing, particularly in the study of fatty acid oxidation and energy metabolism.

• Polymer and Material Research:
  Serves as an isotopically labeled analog in the synthesis and characterization of polyamides (e.g., Nylon 6,6) and other polymeric materials to track reaction pathways and degradation processes.

• Environmental and Industrial Analysis:
  Applied in pollutant tracking and degradation studies of carboxylic acids in environmental matrices, aiding in the identification of oxidation intermediates.

• Analytical Method Validation:
  Functions as a reference compound for verifying accuracy and recovery efficiency in quantitative analytical procedures involving organic acids.

ADVANTAGES  of  1,6-Hexanedioic-d8 Acid | CAS 52089-65-3

• High isotopic enrichment (≥98 atom % D) ensures superior analytical precision.

• Excellent thermal and chemical stability, making it compatible with a wide range of analytical techniques.

• Provides clear mass spectral differentiation from non-deuterated analogs, improving detection reliability.

• Suitable for multi-platform analytical systems, including GC-MS, LC-MS, and NMR spectroscopy.

HANDLING AND SAFETY

• Handling Precautions: Avoid inhalation of dust and contact with skin or eyes. Handle with care under standard laboratory conditions.

• Personal Protective Equipment: Use gloves, lab coat, and safety goggles.

• Storage: Keep in tightly sealed containers, away from oxidizing materials.

• Stability: Chemically stable under normal temperature and pressure.

• Disposal: Dispose of waste in compliance with local environmental and chemical disposal regulations.

SUMMARY
1,6-Hexanedioic-d₈ acid (CAS 52089-65-3) is a high-purity, fully deuterated adipic acid derivative designed for use in analytical chemistry, isotope tracing, and polymer studies. Its precise isotopic labeling, excellent thermal stability, and compatibility with multiple analytical platforms make it a preferred internal standard for quantitative and mechanistic investigations involving dicarboxylic acids and related compounds.

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