1,8-Octanedioic-d12 Acid | CAS 169397-99-3

OVERVIEW  of  1,8-Octanedioic-d12 Acid | CAS 169397-99-3

1,8-Octanedioic-d₁₂ acid (CAS 169397-99-3) is a fully deuterated analog of suberic acid (octanedioic acid) in which all hydrogen atoms have been replaced with deuterium. This isotopically labeled compound is extensively used in mass spectrometry (MS), metabolomics, and analytical chemistry to trace and quantify dicarboxylic acids and related metabolites. Its high deuterium enrichment and chemical stability make it ideal as an internal standard for precision analytical and biochemical studies.

CHEMICAL INFORMATION

• Name: 1,8-Octanedioic-d₁₂ acid

• Molecular Formula: C₈D₁₂O₄

• Molecular Weight: 186.27 g/mol

• CAS Number: 169397-99-3

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated aliphatic dicarboxylic acid

• Solubility: Soluble in alcohols and organic solvents; sparingly soluble in water

APPLICATIONS  of  1,8-Octanedioic-d12 Acid | CAS 169397-99-3

• Mass Spectrometry (MS) Internal Standard:
  Used as a quantitative standard in GC-MS and LC-MS for measuring suberic acid and related metabolites, providing superior analytical precision through isotope dilution techniques.

• Stable Isotope Tracing:
  Serves as a tracer in metabolic pathway studies, enabling the monitoring of fatty acid oxidation, dicarboxylic acid formation, and energy metabolism.

• Metabolomic Research:
  Utilized in lipidomics and metabolomics workflows to study changes in dicarboxylic acid concentrations in biological samples such as plasma, urine, or tissues.

• Analytical Calibration and Validation:
  Functions as a calibration reference compound in quantitative analysis to assess recovery rates and method accuracy for organic acid determination.

• Environmental Chemistry and Toxicology:
  Applied in studies exploring oxidation and degradation pathways of aliphatic acids in environmental samples.

ADVANTAGES  of  1,8-Octanedioic-d12 Acid | CAS 169397-99-3

• High isotopic purity ensures reliable isotope ratio quantification.

• Exhibits excellent chemical and thermal stability for use under varied analytical conditions.

• Enables accurate differentiation from non-deuterated analogs in MS spectra.

• Compatible with both gas chromatography and liquid chromatography techniques.

HANDLING AND SAFETY

• Precautions: Handle using standard laboratory safety protocols; avoid contact with eyes, skin, and clothing.

• Protective Equipment: Use gloves, lab coat, and eye protection.

• Storage: Keep sealed, cool, and dry; avoid exposure to excessive moisture or heat.

• Stability: Stable at ambient temperature under normal laboratory conditions.

• Disposal: Dispose of contents in accordance with institutional and regional waste management regulations.

SUMMARY
1,8-Octanedioic-d₁₂ acid (CAS 169397-99-3) is a fully deuterated, high-purity suberic acid derivative engineered for precise analytical and biochemical applications. Its consistent isotopic labeling, robustness, and reproducibility make it indispensable in quantitative MS-based metabolomics, lipid oxidation studies, and standard calibration protocols, providing unmatched accuracy in the quantification and tracing of dicarboxylic acids in complex systems.