2,2′-Dipyridyl-d8 | CAS 32190-42-4

OVERVIEW  of  2,2′-Dipyridyl-d8 | CAS 32190-42-4

2,2′-Dipyridyl-d8 (also known as Bipyridine-d8 or 2,2′-Bipyridine-d8) is a deuterated heteroaromatic compound derived from 2,2′-bipyridine—a well-known bidentate ligand used in coordination chemistry, catalysis, and analytical research. The substitution of eight aromatic hydrogens with deuterium introduces a distinct isotopic mass difference, allowing for precise isotopic discrimination in spectroscopic and mass-based analytical techniques.

At ResolveMass Laboratories Inc., we synthesize and supply 2,2′-Dipyridyl-d8 with ≥98 atom % deuterium enrichment and ≥98% chemical purity, ensuring that researchers obtain consistent and reproducible analytical results. Its isotopic stability and compatibility with a wide range of analytical and coordination systems make it an indispensable reagent for isotope-labeled studies and analytical method validation.

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CHEMICAL INFORMATION

• Chemical Name: 2,2′-Dipyridyl-d8

• Synonyms: 2,2′-Bipyridine-d8; Bipyridyl-d8; Bpy-d8

• CAS Number: 32190-42-4

• Molecular Formula: C₁₀D₈N₂

• Molecular Weight: 164.24 g/mol

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Structure: Two deuterated pyridine rings linked through their 2-positions

• Appearance: Off-white to pale yellow crystalline solid

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DESCRIPTION AND PROPERTIES
2,2′-Dipyridyl-d8 retains the planar, chelating structure of its non-deuterated analog 2,2′-bipyridine, while offering a unique isotopic signature for analytical distinction. The molecule acts as a strong bidentate ligand, coordinating with transition metals such as Fe²⁺, Ru²⁺, Cu²⁺, and Ni²⁺ to form stable metal–ligand complexes.

The deuteration of all aromatic hydrogen positions enhances its utility in MS and NMR studies by providing a clear mass shift and minimizing proton interference in spectroscopic data. These properties make 2,2′-Dipyridyl-d8 an essential material for quantitative analysis, isotopic tracing, and reaction mechanism elucidation in both organic and inorganic chemistry research.

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APPLICATIONS  of  2,2′-Dipyridyl-d8 | CAS 32190-42-4

1. Stable Isotope Labeling and Tracer Studies:
   2,2′-Dipyridyl-d8 is widely used in isotopic labeling experiments to track ligand behavior in catalytic systems and study the stability of metal–ligand complexes under various reaction conditions.

2. Analytical Standard in Mass Spectrometry:
   The +8 mass unit difference from its non-deuterated counterpart makes it an excellent internal standard or calibration reference in GC-MS and LC-MS applications, ensuring accurate quantitation and mass calibration.

3. NMR Spectroscopy and Calibration:
   In NMR studies, deuterated bipyridyl reduces proton signal interference and simplifies spectra. It is also valuable as a calibration reference and for solvent suppression studies in high-resolution NMR spectroscopy.

4. Coordination and Catalysis Research:
   2,2′-Dipyridyl-d8 is an effective isotopically labeled ligand for investigating metal coordination dynamics, ligand exchange mechanisms, and catalytic reaction pathways involving transition metal complexes.

5. Kinetic and Mechanistic Studies:
   The isotopic substitution offers insight into kinetic isotope effects (KIE), helping researchers understand reaction rates and energy barriers in metal–ligand or redox processes.

6. Environmental and Photochemical Studies:
   In environmental chemistry, 2,2′-Dipyridyl-d8 is used to study metal ion complexation and photoreaction mechanisms in water and organic media. Its deuterium labeling enables precise tracing of molecular transformations.

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ANALYTICAL ADVANTAGES

• Fully deuterated aromatic rings provide a clear mass spectral distinction (+8 Da)

• High isotopic and chemical purity ensuring accurate and reproducible analyses

• Ideal for internal standardization in LC-MS and GC-MS methods

• Enhanced NMR spectral clarity due to deuterium substitution

• Stable under analytical and environmental conditions

• Compatible with a wide range of organic and inorganic solvent systems

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QUALITY AND MANUFACTURING
At ResolveMass Laboratories Inc., 2,2′-Dipyridyl-d8 is produced through advanced deuteration techniques and purified using state-of-the-art chromatographic and crystallization processes. Each batch is verified using NMR spectroscopy, GC-MS, and HPLC to confirm isotopic enrichment, purity, and structural identity.

We adhere to strict quality control and documentation standards to ensure that every product meets the highest research-grade specifications. Our deuterated compounds are trusted by scientists worldwide for analytical method validation, isotope tracing, and quantitative analysis in diverse research applications.

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CONCLUSION
2,2′-Dipyridyl-d8 is an indispensable deuterated standard for isotope labeling, coordination chemistry, and analytical research. Its high isotopic enrichment, chemical stability, and spectroscopic clarity make it a preferred choice for scientists requiring reliable reference materials for advanced analytical studies. With the precision synthesis and rigorous quality control of ResolveMass Laboratories Inc., 2,2′-Dipyridyl-d8 ensures consistent performance, reproducibility, and accuracy across all analytical and research platforms.

 

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