4-Hydroxypiperidine-2,2,3,3,4,5,5,6,6-d9 | CAS: 1219799-39-9

OVERVIEW  of  4-Hydroxypiperidine-2,2,3,3,4,5,5,6,6-d9 | CAS: 1219799-39-9

4-Hydroxypiperidine-2,2,3,3,4,5,5,6,6-d9 (CAS 1219799-39-9) is a fully deuterated derivative of 4-hydroxypiperidine, in which nine hydrogen atoms are replaced with deuterium. This isotopically labeled compound is extensively used in pharmaceutical research, analytical chemistry, and metabolic investigations, where deuterium labeling provides a valuable tool for tracing molecular transformations and studying pharmacokinetic behaviors.

The compound maintains the same structural and chemical characteristics as non-deuterated 4-hydroxypiperidine while exhibiting distinct isotopic mass shifts, allowing for precise quantification and identification in mass spectrometry (MS) and nuclear magnetic resonance (NMR) analyses. Its stable isotopic enrichment makes it an essential reagent in the study of piperidine-based drug molecules, which are widely represented in therapeutic chemistry.

CHEMICAL INFORMATION

• Name: 4-Hydroxypiperidine-d9

• Molecular Formula: C₅D₉NO

• Molecular Weight: 110.20 g/mol

• CAS Number: 1219799-39-9

• Isotopic Labeling: Nine deuterium atoms (≥ 98 atom % D)

• Chemical Class: Deuterated heterocyclic alcohol (secondary amine alcohol)

• Stability: Stable under standard laboratory conditions; hygroscopic in nature

APPLICATIONS  of  4-Hydroxypiperidine-2,2,3,3,4,5,5,6,6-d9 | CAS: 1219799-39-9

• Mass Spectrometry (MS):
  Serves as an internal standard for the quantitative analysis of 4-hydroxypiperidine and related piperidine-based compounds.

• NMR Spectroscopy:
  Used in structural and kinetic studies, benefiting from its deuterium substitution, which reduces background proton signals in spectra.

• Pharmaceutical Research:
  Acts as a labeled intermediate in the synthesis and metabolism studies of piperidine-derived pharmaceuticals, such as CNS agents, anesthetics, and antidepressants.

• Metabolic Pathway Investigation:
  Enables isotopic tracing of metabolic routes and degradation processes involving hydroxypiperidine moieties in biological systems.

• Analytical and Calibration Standard:
  Provides a stable isotope reference for developing analytical methods with improved precision and reproducibility.

ADVANTAGES  of  4-Hydroxypiperidine-2,2,3,3,4,5,5,6,6-d9 | CAS: 1219799-39-9

• High isotopic enrichment (≥ 98 atom % D) ensures excellent analytical clarity.

• Chemically and physically comparable to the unlabeled analogue for direct substitution in studies.

• Enhances detection sensitivity and reduces interference in mass spectrometric analyses.

• Suitable for both qualitative and quantitative research applications.

• Non-radioactive, chemically stable, and environmentally safe isotopic compound.

HANDLING, STORAGE & SAFETY

• Handling: Work under dry, inert atmosphere to prevent moisture absorption.

• Storage: Store at 2–8 °C in tightly sealed containers. Avoid prolonged exposure to air and light.

• Safety: Low hazard under normal conditions; may cause mild irritation upon contact. Use gloves, eye protection, and lab coat.

• Disposal: Dispose of waste according to institutional and environmental safety regulations.

QUALITY & SPECIFICATION

• Purity: ≥ 98 % (chemical)

• Isotopic Enrichment: ≥ 98 atom % D

• Verification Methods: Confirmed by ¹H NMR (absence of proton peaks), ²H NMR, GC–MS, and IR spectroscopy

• Documentation: Certificate of Analysis (CoA) and Safety Data Sheet (SDS) available upon request

SUMMARY
4-Hydroxypiperidine-2,2,3,3,4,5,5,6,6-d9 (CAS 1219799-39-9) is a highly deuterated heterocyclic alcohol widely used in analytical, pharmaceutical, and isotope-labeling studies. With its nine deuterium substitutions, it provides enhanced isotopic differentiation and analytical accuracy in mass spectrometric and NMR analyses. This compound is a crucial tool for drug metabolism research, method validation, and kinetic isotope effect studies, contributing to the advancement of modern chemical and pharmaceutical sciences.