LCMS Analysis of Plant Extract

Advanced Profiling by ResolveMass Laboratories Inc.

Maximize the phytochemical insights of your natural materials with our advanced LCMS Plant Extract Analysis service. At ResolveMass Laboratories Inc., our team of analytical chemists integrates expertise with leading-edge mass spectrometry to accurately detect, quantify, and characterize diverse bioactive components in plant samples.

Introduction

Liquid Chromatography–Mass Spectrometry (LCMS) is one of the most effective approaches for examining the phytochemical makeup of herbal and natural substances. ResolveMass Laboratories Inc. specializes in high-resolution LCMS techniques that separate, detect, and characterize metabolites, alkaloids, flavonoids, and phenolic compounds with precision. Our analytical specialists ensure reproducibility, accuracy, and full traceability across all studies.

For detailed insights into LCMS techniques, explore our comprehensive guide on Impurity Profiling using LCMS.

Why Choose ResolveMass for LCMS Analysis of Plant Extracts

ResolveMass Laboratories Inc. is recognized for its expertise in mass spectrometry and natural product characterization, delivering full-spectrum LCMS profiling solutions for academic, industrial, and pharmaceutical applications. Our facilities utilize advanced instrumentation, verified methodologies, and rigorous quality systems to ensure dependable, compliant results.

High-resolution LCMS and LCMS/MS platforms
Quantitative and qualitative metabolite profiling
Targeted and non-targeted compound detection
Comprehensive data reports with chromatograms and spectra
Expert consultation by Ph.D.-level scientists

Our LCMS Analytical Workflow for Plant Extracts

Our standardized analytical process ensures reliable, reproducible, and precise results. Each phase—from sample preparation through to data analysis—is performed under strict scientific standards.

Step 1

Sample Preparation & Extraction
Careful solvent extraction and filtration to maintain consistency and purity.

Step 2

Chromatographic Separation
High-performance liquid chromatography (HPLC) efficiently separates components before mass spectrometric evaluation.

Step 3

Mass Spectrometric Detection
LCMS or LCMS/MS identifies molecules through their distinct mass-to-charge signatures.

Step 4

Data Processing & Interpretation
Specialists interpret spectra using advanced software to quantify metabolites and produce complete analytical reports.

Applications of LCMS in Plant Research

LCMS technology plays a key role in numerous plant-based research and development activities, including:

Phytochemical mapping of herbal formulations
Discovery of natural products
Evaluation of nutraceuticals and supplements
Authentication and detection of adulteration
Quality verification of botanical materials

For more details, visit our LCMS Services page.

Experience and Expertise You Can Rely On

At ResolveMass Laboratories Inc., every LCMS project is managed by experienced chemists with in-depth knowledge of natural product chemistry, metabolomics, and pharmaceutical development. Our laboratory has analyzed hundreds of plant-based extracts, providing accurate and publication-ready data that support regulatory and R&D needs.

Our operations follow validated procedures, strict quality systems, and data integrity practices consistent with ISO and GLP standards—earning trust from clients across sectors.

Conclusion

ResolveMass Laboratories Inc. provides reliable and precise LCMS Plant Extract Analysis for accurate phytochemical identification, quality verification, and research advancement. Our commitment to transparency and analytical excellence empowers organizations to make informed, data-driven decisions in natural product innovation.

👉 Contact our LCMS specialists to discuss your analytical needs.

FAQs on LCMS Analysis of Plant Extracts

What is LCMS analysis and why is it used for plant extracts?

LCMS (Liquid Chromatography–Mass Spectrometry) separates and identifies compounds within complex mixtures. It helps reveal the full spectrum of active phytochemicals, making it vital for profiling, authentication, and quality evaluation of plant extracts.

How is LCMS different from GCMS in plant analysis?

LCMS is ideal for polar, non-volatile, or thermally unstable compounds, while GCMS is used for volatile substances. LCMS provides higher sensitivity and precise mass accuracy for metabolites like flavonoids and alkaloids.

What amount of sample is needed for LCMS testing?

Only a few milligrams of dry material or a few milliliters of liquid extract are typically required, depending on concentration and target compounds.

How are compounds identified in LCMS data?

Identification relies on retention time, molecular mass, isotopic distribution, and fragmentation patterns compared to libraries or standards.

Can LCMS provide quantitative data?

Yes. Quantification is achieved using internal standards and calibration curves to measure both major and trace components.

What limitations exist in LCMS plant analysis?

Complex matrices, ion suppression, and overlapping peaks can affect analysis, but these are mitigated through optimized chromatography and advanced ionization techniques.

Is LCMS suitable for non-targeted metabolomics?

Yes. LCMS is a premier method for discovering new or unknown metabolites in plants through non-targeted profiling.

Contact ResolveMass Laboratories

References

Bhoi, A. B., Dalwadi, M., & Upadhyay, U. M. (2020). Impurity profiling of pharmaceuticals. International Journal of Pharmaceutical Research and Applications, 5(2), 477–491. https://doi.org/10.35629/7781-0502477491
Bhagwat, A. B., & Khedkar, K. M. (2022). Impurity profiling: A review. Asian Journal of Pharmaceutical Research and Development, 10(2), 135–143. http://dx.doi.org/10.22270/ajprd.v10i2.1052
Bondigalla, R. (2017). Development of impurity profiling methods using modern analytical techniques. Critical Reviews in Analytical Chemistry, 47(1), 24–36. https://doi.org/10.1080/10408347.2016.1169913