4-Hydroxypiperidine-3,3,4,5,5-d5 | CAS 1219799-35-5

OVERVIEW  of  4-Hydroxypiperidine-3,3,4,5,5-d5 | CAS 1219799-35-5

4-Hydroxypiperidine-3,3,4,5,5-d5 (CAS 1219799-35-5) is a partially deuterated analogue of 4-hydroxypiperidine, featuring five deuterium atoms substituted at the 3, 4, and 5 positions of the piperidine ring. This compound is widely used as an isotopically labeled reference standard and intermediate in analytical, pharmaceutical, and biochemical research. The introduction of deuterium enhances the compound’s mass spectrometric detectability while maintaining the same chemical behavior as the non-deuterated analogue, making it ideal for quantitative studies and metabolic tracing.

Because piperidine derivatives form the core of numerous pharmaceutical compounds, 4-hydroxypiperidine-3,3,4,5,5-d5 serves as a valuable tool in drug metabolism and pharmacokinetic research, enabling scientists to differentiate between native and labeled species during analytical evaluations.

CHEMICAL INFORMATION

• Name: 4-Hydroxypiperidine-d5

• Molecular Formula: C₅H₄D₅NO

• Molecular Weight: 106.18 g/mol

• CAS Number: 1219799-35-5

• Isotopic Labeling: Five deuterium atoms (at positions 3, 3, 4, 5, 5)

• Chemical Class: Deuterated heterocyclic amine alcohol

• Stability: Stable under standard laboratory conditions; hygroscopic

APPLICATIONS  of  4-Hydroxypiperidine-3,3,4,5,5-d5 | CAS 1219799-35-5

• Mass Spectrometry (MS):
  Used as a stable isotopic internal standard in the quantification of 4-hydroxypiperidine and its analogues in biological and pharmaceutical samples.

• NMR Spectroscopy:
  Serves as an NMR reference material where selective deuteration reduces proton signal interference and enhances spectral clarity.

• Pharmaceutical Development:
  Functions as an isotopically labeled building block for synthesizing deuterated derivatives of piperidine-based drugs and intermediates.

• Metabolic and Pharmacokinetic Studies:
  Used in isotopic tracing to investigate the metabolism, distribution, and clearance of piperidine-containing compounds in biological systems.

• Analytical Chemistry:
  Provides a quantitative calibration standard for LC–MS and GC–MS methods to ensure accuracy and reproducibility.

ADVANTAGES  of  4-Hydroxypiperidine-3,3,4,5,5-d5 | CAS 1219799-35-5

• High isotopic enrichment (≥ 98 atom % D) for precise analytical applications.

• Chemically equivalent to the unlabeled compound, allowing consistent comparison.

• Enhanced signal differentiation in mass spectrometry and NMR spectroscopy.

• Non-radioactive, stable, and environmentally safe labeling choice.

• Versatile intermediate for isotopically labeled drug synthesis and kinetic isotope effect studies.

HANDLING, STORAGE & SAFETY

• Handling: Handle under dry and inert conditions; avoid prolonged exposure to air and moisture.

• Storage: Keep sealed at 2–8 °C in a cool, dry place, protected from direct sunlight.

• Safety: Low toxicity; may cause mild irritation to skin or eyes upon contact. Use gloves and protective eyewear when handling.

• Disposal: Dispose of material and residues according to local environmental and safety regulations.

QUALITY & SPECIFICATION

• Purity: ≥ 98 % (chemical)

• Isotopic Enrichment: ≥ 98 atom % D

• Analytical Verification: Confirmed by ¹H NMR (absence of proton peaks), ²H NMR, GC–MS, and IR spectroscopy

• Documentation: Certificate of Analysis (CoA) and Safety Data Sheet (SDS) available upon request

SUMMARY
4-Hydroxypiperidine-3,3,4,5,5-d5 (CAS 1219799-35-5) is a high-quality deuterium-labeled compound designed for advanced analytical, pharmaceutical, and biochemical research. With selective deuterium incorporation, it serves as a robust tool for mass spectrometry calibration, metabolic pathway analysis, and drug synthesis involving piperidine frameworks. Its stability, isotopic precision, and structural equivalence to the non-deuterated form make it indispensable for quantitative isotopic labeling studies and trace-level detection in complex biological matrices.

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