4-Hydroxypyridine-d5 | CAS 45503-33-1

OVERVIEW  of  4-Hydroxypyridine-d5 | CAS 45503-33-1

4-Hydroxypyridine-d5 (CAS 45503-33-1) is a fully deuterated aromatic heterocycle featuring five deuterium atoms on the pyridine ring. As the isotopically labeled analog of 4-hydroxypyridine, it provides enhanced mass differentiation, making it highly valuable for LC-MS and GC-MS workflows. This compound is widely used as an internal standard, in metabolic pathway studies, impurity profiling, pharmaceutical research, and kinetic isotope effect investigations. Its stability and structural equivalence to the native compound make it ideal for precise quantitative and qualitative analysis.

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CHEMICAL INFORMATION
Chemical Name: 4-Hydroxypyridine-d5
Synonyms: Deuterated 4-hydroxypyridine; Pyridin-4-ol-d5
CAS Number: 45503-33-1
Molecular Formula: C₅D₅NO
Molecular Weight: 100.12 g/mol
Isotopic Enrichment: ≥98 atom % D
Structure Type: Deuterated heteroaromatic compound

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APPLICATIONS  of  4-Hydroxypyridine-d5 | CAS 45503-33-1

• LC-MS / GC-MS Internal Standard: Enables high-precision quantitation of 4-hydroxypyridine in biological, pharmaceutical, and industrial samples.

• Metabolomics & Pathway Analysis: Useful in studies involving pyridine metabolism and oxidative biotransformations.

• Pharmaceutical R&D: Supports impurity profiling, stability studies, and mechanistic investigations.

• Kinetic Isotope Effect Studies: Deuterium substitution allows exploration of reaction kinetics and mechanistic pathways.

• Environmental & Industrial Monitoring: Facilitates accurate tracking of pyridine derivatives in complex matrices.

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SUMMARY
4-Hydroxypyridine-d5 (CAS 45503-33-1) is a high-purity, fully deuterated pyridine derivative optimized for LC-MS, GC-MS, and mechanistic research applications. With five deuterium atoms providing a strong isotopic signature, it offers exceptional analytical reliability for quantitative assays, impurity profiling, metabolic studies, and kinetic isotope investigations.

 

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