4-Piperidine-d9-carboxylic Acid | CAS 1219798-43-2

OVERVIEW
4-Piperidine-d₉-carboxylic acid is a fully deuterium-labeled analog of 4-piperidinecarboxylic acid, in which all nine hydrogen atoms on the piperidine ring are replaced by deuterium. This isotopic substitution provides a +9 Da molecular weight shift while maintaining identical chemical structure and functionality to the non-deuterated compound. The compound’s high isotopic enrichment makes it an exceptional stable isotope-labeled standard for use in analytical chemistry, mass spectrometry, pharmaceutical research, and metabolic studies.

The piperidine ring is a common structural motif in numerous biologically active compounds, pharmaceuticals, and intermediates. Therefore, 4-piperidine-d₉-carboxylic acid plays an important role in the synthesis of deuterated drugs, isotope tracing, and pharmacokinetic investigations, helping researchers explore reaction mechanisms and metabolic stability in labeled systems.

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CHEMICAL INFORMATION

• Name: 4-Piperidine-d₉-carboxylic acid

• Molecular Formula: C₆D₉NO₂

• Molecular Weight: 138.21 g/mol

• CAS Number: 1219798-43-2

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated heterocyclic carboxylic acid; stable isotope-labeled piperidine derivative

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APPLICATIONS  of  4-Piperidine-d9-carboxylic Acid | CAS 1219798-43-2

• Analytical Chemistry and Mass Spectrometry:
  4-Piperidine-d₉-carboxylic acid is widely used as an internal standard or reference compound in LC-MS and GC-MS analyses. Its +9 Da mass difference provides a clear isotopic distinction from the non-labeled analog, allowing precise quantification and accurate calibration in analytical methods.

• Pharmaceutical and Medicinal Chemistry:
  Serves as a key building block for deuterated pharmaceuticals and drug intermediates. The deuterium labeling enhances metabolic stability and helps in studying drug degradation pathways and reaction kinetics.

• Metabolic and Isotopic Tracer Studies:
  Employed in metabolic profiling and isotope tracing experiments to investigate the transformation and bioavailability of piperidine-based compounds in biological systems.

• Synthetic Organic Chemistry:
  Functions as a precursor in the synthesis of deuterium-labeled derivatives of piperidine-based bioactive molecules, such as anesthetics, alkaloids, and central nervous system agents.

• NMR and Spectroscopic Applications:
  Utilized in structural and mechanistic studies where deuterium labeling assists in peak simplification and identification through ¹H NMR and ²H NMR spectroscopy.

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ADVANTAGES  of  4-Piperidine-d9-carboxylic Acid | CAS 1219798-43-2

• High isotopic enrichment ensures superior analytical precision and reproducibility.

• Chemically identical to native 4-piperidinecarboxylic acid, maintaining identical reactivity and solubility.

• Enhances sensitivity and selectivity in isotope dilution assays and quantitative MS methods.

• Non-radioactive, safe for laboratory use, and stable under ambient conditions.

• Applicable across multiple research domains, including pharmaceutical, biochemical, and spectroscopic studies.

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HANDLING

• Hazards: Low toxicity compound; may cause slight irritation to eyes, skin, or respiratory tract upon prolonged exposure.

• Precautions: Handle with standard laboratory protective equipment—gloves, goggles, and lab coat. Avoid generating dust or inhaling vapors.

• Storage: Keep in an airtight container under dry and cool conditions, away from strong oxidizing agents.

• Disposal: Dispose of according to institutional chemical waste protocols; compound is non-hazardous but should not be discharged into drains.

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QUALITY & SPECIFICATION

• Chemical Purity: ≥ 98 %

• Isotopic Enrichment: ≥ 98 atom % D

• Water Content: ≤ 0.5 %

• Analytical Verification: Verified by ¹H NMR, ²H NMR, IR spectroscopy, and LC-MS analysis

• Appearance: White crystalline or powdery solid

• COA Availability: Supplied with a batch-specific Certificate of Analysis confirming isotopic enrichment and purity

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SUMMARY
4-Piperidine-d₉-carboxylic acid (CAS 1219798-43-2) is a high-purity, deuterium-labeled piperidine derivative widely used as an internal standard and tracer in analytical, pharmaceutical, and biochemical research. Its complete deuterium substitution enhances isotopic resolution in MS-based studies and supports synthesis of metabolically stable deuterated compounds. Due to its reliability, stability, and isotopic precision, this compound is an essential reagent for isotope labeling research, drug metabolism studies, and advanced analytical applications.

 

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