Acetone-d6 | CAS 666-52-4

PRODUCT OVERVIEW

Acetone-d6 | CAS 666-52-4  is a high-purity deuterated solvent widely used in nuclear magnetic resonance (NMR) spectroscopy, analytical chemistry, and specialized research applications. It is an isotopically labeled form of acetone in which all six hydrogen atoms are replaced with deuterium (²H or D), making it invaluable for obtaining high-resolution NMR spectra with minimal proton background interference.

At ResolveMass Laboratories Inc., our acetone-d₆ is manufactured under stringent quality controls to ensure consistent isotopic purity, low water content, and excellent spectroscopic performance. It serves as a reliable NMR solvent for both academic and industrial laboratories that demand precision and reproducibility.

KEY FEATURES & BENEFITS

ISOTOPIC PURITY

Acetone-d₆ exhibits high deuteration levels (>99.5% D), minimizing residual proton signals during NMR analysis. This results in cleaner baselines and enhanced spectral clarity, particularly for proton (¹H) NMR experiments where solvent peaks can otherwise obscure critical data.

EXCEPTIONAL SPECTRAL PERFORMANCE

With deuterium replacing virtually all hydrogen atoms, acetone-d₆ provides a diminished solvent signal that does not interfere with sample peaks. Additionally, its characteristic residual solvent peak at ~2.05 ppm is widely accepted and easily distinguishable in the ¹H NMR spectrum, aiding spectral calibration and interpretation.

LOW IMPURITIES & MOISTURE

Our acetone-d₆ is processed to achieve minimal water content and trace impurities, reducing unwanted interactions that may compromise sensitive analytes or shift chemical signals. This results in more reliable quantitative and qualitative analyses.

COMPATIBILITY & VERSATILITY

Compatible with a wide range of NMR tubes and sample types, acetone-d₆ is ideal for organic molecules, polymers, pharmaceuticals, and complex mixtures. Its moderate polarity makes it suitable for dissolving both polar and moderately non-polar compounds.

CHEMICAL AND PHYSICAL PROPERTIES

(Note: Values represent typical specifications and may vary slightly between production lots.)

APPLICATIONS  of  Acetone-d6 | CAS 666-52-4

NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROSCOPY

Acetone-d₆ is predominantly used as a deuterated NMR solvent. Its high deuterium content ensures that:

• The lock frequency in NMR instruments remains stable.

• Solvent background signals are minimized in ¹H, ¹³C, and multinuclear NMR.

• Spectral baselines are clean, enhancing peak resolution and integration accuracy.

Common applications include:

• Structural elucidation of organic molecules

• Reaction monitoring and kinetic studies

• Purity assessment and compound identification

• Complex mixture analysis

QUANTITATIVE NMR (qNMR)

Due to its predictable and well-defined residual proton peak, acetone-d₆ facilitates accurate quantitative measurements when paired with internal standards. Its consistent performance aids in concentration determination for APIs, intermediates, and reference materials.

SOLVENT SYSTEMS IN ANALYTICAL CHEMISTRY

Beyond NMR, acetone-d₆ can serve as a selective solvent for:

• Solubility profiling

• Sample preparation for spectroscopic and chromatographic analyses

• Isotopic labeling studies

RESEARCH & DEVELOPMENT

Used in academic, pharmaceutical, and industrial R&D settings where deuterated environments or solvents are required for mechanistic investigations, isotope effect studies, or advanced spectroscopic methodologies.

QUALITY ASSURANCE

At ResolveMass Laboratories Inc., every batch of acetone-d₆ undergoes rigorous QC testing, including:

• Isotopic purity verification

• Residual proton assessment via NMR

• Moisture content analysis

• Chemical identity confirmation

This ensures that researchers and analysts receive a consistent, high-performance solvent that meets or exceeds industry standards.