(Aminomethyl-d2)phosphonic Acid | CAS 30926-24-0

OVERVIEW
(Aminomethyl-d₂)phosphonic acid is a deuterium-labeled derivative of aminomethylphosphonic acid (AMPA), a well-known phosphonic acid compound. In this isotopically enriched analog, two hydrogen atoms on the aminomethyl group are replaced with deuterium atoms. This modification increases the molecular weight by 2 Da while maintaining the same chemical structure and reactivity, making it valuable in analytical, environmental, and biochemical studies involving isotope tracing and mass spectrometric quantification.

This compound is frequently used as a stable isotope-labeled internal standard for the analysis of AMPA, a primary metabolite of glyphosate herbicide, in environmental and biological samples. Its high isotopic purity and chemical equivalence to the non-labeled analog ensure accurate quantification and reliable identification in trace-level analysis.

CHEMICAL INFORMATION

• Name: (Aminomethyl-d₂)phosphonic acid

• Molecular Formula: CD₂NH₂PO₃H₂

• Molecular Weight: 113.04 g/mol

• CAS Number: 30926-24-0

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated organophosphorus compound; stable isotope-labeled amino phosphonic acid

• Stability: Stable under normal laboratory conditions; hygroscopic in nature

APPLICATIONS  of  (Aminomethyl-d2)phosphonic Acid | CAS 30926-24-0

• Environmental and Agricultural Studies:
  Used as a deuterated internal standard for detecting and quantifying aminomethylphosphonic acid (AMPA), a key degradation product of glyphosate, in soil, water, and plant matrices via LC-MS/MS or GC-MS techniques.

• Analytical Chemistry and Mass Spectrometry:
  Serves as a calibration compound or isotopic tracer to improve accuracy in isotope dilution mass spectrometry (IDMS) for trace-level detection of AMPA and related compounds.

• Biochemical and Toxicological Research:
  Utilized in metabolism and degradation studies of glyphosate and its derivatives, helping to elucidate biochemical pathways and environmental fate through isotope labeling.

• Isotopic Labeling and Mechanistic Studies:
  Deuterium substitution provides kinetic isotope effect (KIE) insights into hydrogen exchange and enzymatic reactions involving phosphonic acids.

ADVANTAGES  of  (Aminomethyl-d2)phosphonic Acid | CAS 30926-24-0

• High isotopic enrichment ensures excellent analytical resolution.

• Chemically and functionally identical to AMPA, ensuring accurate internal standard performance.

• Non-radioactive and safe for use in laboratory and environmental research.

• Enhances precision and sensitivity in LC-MS and GC-MS quantification.

• Useful for both environmental monitoring and biochemical studies of herbicide degradation.

HANDLING

• Hazards: Low acute toxicity; may cause mild irritation to skin, eyes, or respiratory tract upon prolonged exposure.

• Precautions: Handle using standard laboratory PPE — gloves, goggles, and lab coat. Avoid contact with skin and eyes.

• Storage: Keep tightly closed in a cool, dry place. Avoid exposure to moisture and direct sunlight.

• Disposal: Dispose of in accordance with local regulations for non-hazardous organic phosphonic acids.

QUALITY & SPECIFICATION

• Chemical Purity: ≥ 98 %

• Isotopic Enrichment: ≥ 98 atom % D

• Water Content: ≤ 0.5 %

• Analytical Verification: Characterized by ¹H NMR, ²H NMR, ³¹P NMR, and LC-MS to confirm isotopic and chemical purity

• Appearance: White crystalline powder

• COA Availability: Supplied with lot-specific Certificate of Analysis verifying isotopic and chemical composition

SUMMARY
(Aminomethyl-d₂)phosphonic acid (CAS 30926-24-0) is a high-purity, deuterium-labeled analog of aminomethylphosphonic acid used extensively as an internal standard and isotopic tracer in environmental and analytical research. Its precise isotopic labeling enhances the accuracy of glyphosate metabolite quantification, while its stability and safety make it an essential tool for studies in mass spectrometry, environmental chemistry, and kinetic isotope analysis.