Deuterated 2-Chloroethanol-1,1,2,2-d4 | CAS 117067-62-6

Deuterated 2-Chloroethanol-1,1,2,2-d4 | CAS 117067-62-6 is a stable isotope-labelled analogue of 2-chloroethanol in which four hydrogen atoms are replaced with deuterium (^2H or D). This isotopically enriched compound retains nearly identical chemical behavior to its non-labelled counterpart while exhibiting a predictable mass shift of +4 Da (M+4), making it an excellent internal standard and reference material for advanced analytical applications. The compound has a molecular formula of C₂HClD₄O and a molecular weight of 84.54 g/mol. It is commonly supplied with approximately 98 atom % deuterium enrichment and high chemical purity for research applications.

At ResolveMass Laboratories Inc., we recognize the critical role that isotope-labelled reference standards play in pharmaceutical analysis, environmental monitoring, forensic investigations, and bioanalytical method development. Deuterated 2-Chloroethanol-1,1,2,2-d4 enables highly accurate quantification while minimizing analytical variability caused by sample preparation, extraction efficiency, matrix effects, and instrument response fluctuations.

Chemical Properties

Deuterated 2-Chloroethanol-1,1,2,2-d4 is typically supplied as a clear, colorless liquid. Representative physicochemical properties include:

• CAS Number: 117067-62-6
• Molecular Formula: C₂HClD₄O
• Molecular Weight: 84.54 g/mol
• Mass Shift: M+4
• Isotopic Enrichment: Approximately 98 atom % D
• Boiling Point: Approximately 129°C
• Melting Point: Approximately –89°C
• Density: Approximately 1.26 g/mL at 25°C

Applications in LC-MS/MS and GC-MS Analysis

Stable isotope-labelled compounds are considered the gold standard for quantitative mass spectrometry. Deuterated 2-Chloroethanol-1,1,2,2-d4 behaves almost identically to native 2-chloroethanol during chromatographic separation while remaining distinguishable by mass spectrometry. This allows analysts to compensate for analytical losses throughout the entire workflow.

Typical analytical applications include:

• LC-MS/MS quantitative analysis
• GC-MS residue testing
• Pharmaceutical impurity profiling
• Method validation studies
• Analytical method development
• Recovery and extraction efficiency studies
• Quality control testing
• Calibration standard preparation
• Environmental contaminant monitoring
• Toxicological investigations

Because the labelled analogue co-elutes with the target analyte while providing a distinct isotopic signal, it improves precision, reproducibility, and confidence in quantitative results.

Importance as an Internal Standard

Internal standards are essential in modern analytical chemistry because they compensate for variations introduced during sample preparation, extraction, injection, ionization, and instrument performance. Deuterated compounds provide superior correction compared to structurally unrelated compounds since they closely mimic the analyte throughout the analytical process.

Using Deuterated 2-Chloroethanol-1,1,2,2-d4 can help laboratories:

• Improve quantitative accuracy
• Correct matrix suppression or enhancement
• Minimize instrument-to-instrument variability
• Enhance method robustness
• Meet regulatory validation requirements
• Increase reproducibility across analytical batches

These characteristics make isotope-labelled standards indispensable in regulated pharmaceutical and bioanalytical laboratories.

Pharmaceutical Research Applications

Deuterated 2-Chloroethanol-1,1,2,2-d4 is valuable throughout pharmaceutical research and development. Scientists use isotope-labelled compounds during:

• Drug development programs
• Pharmaceutical impurity investigations
• Stability-indicating analytical methods
• Forced degradation studies
• Manufacturing process development
• GMP analytical testing
• Pharmacokinetic research
• Bioanalytical assay development
• Clinical sample analysis
• Reference standard qualification

Because isotope-labelled compounds closely resemble the native molecule, they provide exceptional analytical performance during method validation and routine quality control.

Role in Environmental and Toxicological Analysis

2-Chloroethanol and related chlorinated alcohols may require monitoring in environmental, industrial, and occupational settings. Deuterated standards improve trace-level quantification in complex matrices including water, soil, biological fluids, and industrial samples.

Applications include:

• Environmental residue monitoring
• Industrial hygiene investigations
• Occupational exposure assessments
• Chemical manufacturing quality control
• Forensic toxicology
• Research involving chlorinated organic compounds

The use of isotope-labelled internal standards significantly enhances confidence in low-level detection where analytical accuracy is essential.

Quality You Can Trust

ResolveMass Laboratories Inc. is committed to supplying high-quality stable isotope-labelled reference materials that meet the demanding requirements of pharmaceutical, biotechnology, academic, and contract research laboratories. Every product is sourced and handled to support analytical reproducibility and reliable research outcomes.

Our isotope-labelled standards are suitable for:

• Pharmaceutical laboratories
• CROs and CDMOs
• Biotechnology companies
• Regulatory laboratories
• Environmental testing laboratories
• Academic research institutions
• Clinical research organizations
• Government research facilities

Why Choose ResolveMass Laboratories Inc.?

Researchers choose ResolveMass Laboratories Inc. because of our commitment to scientific quality, technical expertise, and dependable customer support. We understand the stringent requirements of analytical laboratories and provide isotope-labelled compounds that help scientists generate reliable, reproducible, and regulatory-compliant data.

Whether you are developing new analytical methods, validating LC-MS/MS or GC-MS procedures, conducting pharmaceutical impurity analysis, or performing environmental monitoring, Deuterated 2-Chloroethanol-1,1,2,2-d4 offers the performance and consistency required for high-quality analytical research.

For product availability, technical specifications, or custom isotope-labelled reference standards, contact ResolveMass Laboratories Inc. to discuss your analytical and pharmaceutical research requirements.

 

Learn more about Deuterated Chemicals through,

• Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends
• Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 
• ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States.
• Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 
• How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 
• How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 
• Deuterium-Labelled Compounds — Synthesis, Applications & Ordering 
• Custom Synthesis of Deuterated Chemicals