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Deuterated 2-(Dimethylamino)ethyl methacrylate-d15 | CAS 2867-47-2

$2,070.00

Pack size: 1g,For larger quantity, please enquire.
Availability: Lead time 4-6 weeks
Catalogue number: RM-D-276
Synonyms: DMAEMA-d15;d15-DMAEMA;2-(Dimethylamino)ethyl methacrylate-d15;Dimethylaminoethyl methacrylate-d15;Deuterated DMAEMA;Deuterium-labeled DMAEMA;(2-(Dimethylamino)ethyl) 2-methylprop-2-enoate-d15
Price Match Policy: We match verified competitor quote prices.

SKU: RM-D-276 Category: Deuterated Chemicals

Description
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OVERVIEW

Deuterated 2-(Dimethylamino)ethyl methacrylate-d15 | CAS 2867-47-2 is an isotopically enriched analog of the widely used monomer DMAEMA, in which fifteen hydrogen atoms are replaced with deuterium. This selective deuterium incorporation provides enhanced analytical performance, improved NMR signal clarity, and optimal behavior for mechanistic polymer studies and kinetic isotope effect analyses. Owing to its reactive methacrylate functionality and tertiary amine side-chain, DMAEMA-d15 is a highly versatile monomer suitable for controlled radical polymerization, surface modification, polymer brush synthesis, ion-responsive materials, micelle formation studies, and advanced characterization workflows.

ResolveMass Laboratories Inc. supplies research-grade and custom-purified DMAEMA-d15 to support pharmaceutical, academic, and industrial R&D programs, particularly in polymer science, analytical method development, drug delivery, isotopic tracing, and polymer–protein interaction studies.

CHEMICAL INFORMATION

Chemical Name: Deuterated 2-(Dimethylamino)ethyl methacrylate-d15
CAS Number: 2867-47-2
Molecular Formula: C8D15NO2
Isotopic Labeling: 15 deuterium atoms
Functional Groups: Methacrylate ester, tertiary amine
Physical Form: Colorless to pale liquid, moisture-sensitive, polymerizable ester

The structural framework of DMAEMA-d15 mirrors the non-deuterated monomer; however, the introduction of deuterium atoms significantly enhances stability against proton-based degradation and offers superior mass spectral resolution. The tertiary amine ensures pH-dependent ionizability, making the monomer essential for synthesizing polycations, zwitterionic materials, and responsive polymer systems.

KEY FEATURES

High deuteration efficiency for reliable quantitative and qualitative analysis
Excellent compatibility with RAFT, ATRP, FRP, and photopolymerization methods
Strong utility in NMR, LC–MS, GC–MS, and isotopic tracing
Tertiary amine moiety supports pH-responsive polymer systems
Valuable for polymer architecture studies: block copolymers, brushes, hydrogels
Enables internal standardization for analytical method validation

ANALYTICAL AND ISOTOPIC ADVANTAGES

DMAEMA-d15 is widely adopted in laboratories that require exceptional analytical precision. The deuterated backbone provides:

Enhanced NMR Clarity

Deuterium substitution minimizes proton-proton coupling, improving spectral interpretation for polymerization kinetics, chain-end fidelity, and copolymer composition.

Improved Mass Spectrometry Resolution

The isotopic mass shift allows DMAEMA-d15 to serve as an internal standard for quantitative LC–MS and GC–MS workflows, improving accuracy in complex matrices.

Mechanistic Polymerization Studies

The kinetic isotope effect (KIE) provides insights into radical propagation, termination steps, and monomer reactivity ratios in advanced polymerization systems.

Reduced Background Interference

Deuterated materials reduce spectral noise, enabling clearer quantification during analytical development or impurity profiling.

APPLICATIONS of Deuterated 2-(Dimethylamino)ethyl methacrylate-d15 | CAS 2867-47-2

Polymer Research & Synthesis

DMAEMA-d15 is widely used to create cationic and pH-responsive polymers, including:

Poly(DMAEMA) and copolymers for gene delivery
Stimuli-responsive hydrogels
Thermo-responsive coatings
Surface-grafted polymer brushes
Polymer micelles and nanocarriers

Its compatibility with controlled polymerization (ATRP, RAFT) enables precise molecular weight control and narrow dispersity, essential for biomedical experimentation and materials engineering.

Analytical Chemistry & Method Development

As an internal standard, DMAEMA-d15 provides:

Calibration for trace analysis of DMAEMA monomers
Validation of extraction, purification, and residual monomer quantification in polymer products
Enhanced robustness of LC–MS workflows

Isotopic Tracing & Mechanistic Studies

The deuterium labeling makes DMAEMA-d15 ideal for monitoring:

Polymer degradation pathways
Copolymer rearrangement
Molecular interaction mapping
Reaction kinetics and radical dynamics

Biomaterials & Drug Delivery

Cationic polymer chains derived from DMAEMA-d15 support:

DNA/RNA complexation studies
Protein–polymer interaction analysis
Tailored release systems for experimental therapeutics

ADVANTAGES FOR FORMULATION AND MATERIAL SCIENCE

pH-responsiveness: The tertiary amine group allows polymer chains to switch from neutral to cationic depending on environmental pH.
Hydrophilicity tuning: Useful for adjusting polymer solubility, micelle behavior, and hydrogel swelling.
Surface modification: Enables preparation of anti-fouling coatings, biosensor surfaces, and charge-tunable membranes.
Kinetic isotope stability: Reduced hydrogen-exchange improves reproducibility in long-term studies.

WHY RESOLVEMASS LABORATORIES INC.

ResolveMass Laboratories Inc. provides high-purity deuterated monomers tailored for analytical chemistry, polymer science, biotechnology, and pharmaceutical R&D. Our team ensures: