Deuterated 2-(Methoxy-d3)ethan-1-ol | CAS 97840-77-2

Deuterated 2-(Methoxy-d3)ethan-1-ol (CAS 97840-77-2) is a stable isotope-labeled compound in which the three hydrogen atoms of the methoxy group are replaced with deuterium (²H or D). This isotopically enriched alcohol is widely used in pharmaceutical research, analytical chemistry, metabolomics, and mass spectrometry applications where precise molecular tracking and accurate quantitative analysis are essential.

Unlike radioactive tracers, deuterium-labeled compounds offer excellent chemical stability while maintaining nearly identical chemical behavior to their non-labeled counterparts. This makes Deuterated 2-(Methoxy-d3)ethan-1-ol an ideal reference material for developing analytical methods, validating assays, and studying reaction pathways.

Chemical Information

• Product Name: Deuterated 2-(Methoxy-d3)ethan-1-ol
• CAS Number: 97840-77-2
• Molecular Formula: C₃H₇DO₂ (depending on isotope notation)
• Isotopic Label: Three deuterium atoms on the methoxy group
• Appearance: Typically a clear, colorless liquid
• Application: Stable isotope-labeled analytical standard and research chemical

The selective placement of deuterium on the methoxy group enables researchers to distinguish this compound from its unlabeled analogue using high-resolution mass spectrometry without significantly altering its chemical properties.

Applications in Pharmaceutical Research :

Deuterated 2-(Methoxy-d3)ethan-1-ol is widely utilized throughout pharmaceutical development. Stable isotope-labeled compounds have become indispensable tools for improving analytical accuracy and supporting regulatory-quality research.

Common pharmaceutical applications include:

• Development and validation of LC-MS/MS analytical methods
• Internal standards for quantitative bioanalysis
• Drug metabolism and metabolic pathway investigations
• Pharmacokinetic and ADME studies
• Stability studies during pharmaceutical development
• Quality control and impurity analysis
• Method transfer between analytical laboratories

Because the deuterated analogue closely mimics the behavior of the native molecule, it minimizes analytical variability while providing a distinguishable mass signal during detection.

Role in Mass Spectrometry

Mass spectrometry is one of the primary analytical techniques that benefits from stable isotope-labeled compounds. Deuterated 2-(Methoxy-d3)ethan-1-ol serves as a reliable internal standard by compensating for variations introduced during sample preparation, extraction efficiency, chromatographic separation, and ionization.

Benefits in LC-MS and GC-MS workflows include:

• Improved quantitative accuracy
• Enhanced reproducibility between analyses
• Correction for matrix effects
• Reduced instrument-to-instrument variability
• Increased confidence in trace-level quantification
• Support for validated analytical methods

The predictable mass shift generated by deuterium incorporation enables analysts to simultaneously monitor labeled and unlabeled compounds without chromatographic interference.

Importance in Method Development

Analytical method development requires highly characterized reference materials that provide reproducible performance across multiple experiments. Deuterated compounds are frequently incorporated during method optimization because they allow scientists to monitor extraction recovery, evaluate instrument performance, and assess analytical robustness.

Researchers use Deuterated 2-(Methoxy-d3)ethan-1-ol to:

• Optimize chromatographic conditions
• Validate calibration curves
• Determine assay precision and accuracy
• Evaluate recovery during sample preparation
• Monitor analytical performance over time
• Improve assay robustness for regulatory submissions

These capabilities contribute to reliable analytical methods suitable for pharmaceutical, biotechnology, and academic research.

Research Applications

Beyond pharmaceutical analysis, Deuterated 2-(Methoxy-d3)ethan-1-ol supports a broad range of scientific investigations. Stable isotope-labeled compounds are commonly employed wherever molecular identification and accurate quantification are required.

Typical research areas include:

• Organic synthesis
• Stable isotope chemistry
• Reaction mechanism studies
• Metabolomics
• Chemical biology
• Environmental analysis
• Academic laboratory research
• Analytical chemistry method development

The compound’s isotopic label provides an efficient means of tracing molecular transformations without introducing significant changes to chemical reactivity.

Advantages of Stable Isotope Labeling

Stable isotope-labeled compounds offer numerous advantages compared with conventional analytical standards.

Key benefits include:

• Non-radioactive and safe for laboratory research
• High analytical specificity
• Excellent compatibility with LC-MS/MS and GC-MS systems
• Improved quantitative precision
• Reliable correction of sample preparation losses
• Better reproducibility across laboratories
• Simplified identification of target analytes

These advantages have made deuterated reference materials standard tools in modern pharmaceutical and analytical laboratories worldwide.

Quality Considerations

High-quality isotope-labeled compounds are essential for generating reproducible analytical results. Researchers typically select materials that are produced under stringent quality standards and characterized using advanced analytical techniques.

Important quality attributes include:

• High chemical purity
• Verified isotopic enrichment
• Structural identity confirmation
• Batch-to-batch consistency
• Reliable analytical documentation
• Suitable packaging for laboratory storage and handling

Careful quality control helps ensure dependable performance throughout research and analytical workflows.

ResolveMass Laboratories Inc.

ResolveMass Laboratories Inc. supplies high-quality stable isotope-labeled compounds that support pharmaceutical research, analytical chemistry, and life science applications. Researchers rely on isotope-labeled reference materials for quantitative LC-MS/MS analysis, method validation, drug development, and advanced analytical investigations.

Deuterated 2-(Methoxy-d3)ethan-1-ol (CAS 97840-77-2) is suitable for research applications requiring accurate isotope labeling and dependable analytical performance. Each material is intended to support scientists in developing robust analytical methods, improving quantitative accuracy, and advancing pharmaceutical and biochemical research.

Disclaimer: This product is intended for research and laboratory use only. It is not intended for human or veterinary use, therapeutic applications, or diagnostic procedures unless otherwise specified.

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