Deuterated (4-Chlorophenyl-4′-hydroxyphenyl)-d8 sulfone

OVERVIEW

Deuterated (4-Chlorophenyl-4′-hydroxyphenyl)-d₈ sulfone is the heavy hydrogen (deuterium, ²H) labeled analog of the unlabeled parent compound 4-chlorophenyl-4′-hydroxyphenyl sulfone. In this derivative, eight hydrogen atoms are replaced with deuterium, resulting in a precise mass shift while preserving relevant physicochemical characteristics of the non-labeled molecule.

The replacement of protium (¹H) with deuterium provides several analytical advantages, particularly in mass spectrometry (MS) — the compound behaves identically in extraction, ionization, and chromatographic phases but can be unambiguously distinguished by its mass.

This compound is widely used as an internal standard in LC-MS/MS and GC-MS methods to improve accuracy, precision, and quantitation of trace-level analytes in complex matrices such as biological fluids, environmental extracts, and pharmaceutical formulations.

KEY FEATURES & BENEFITS

High Isotopic Purity
• Typically ≥ 98% deuterium incorporation at designated positions
• Minimizes signal overlap with native analytes
• Reduces isotopic interference or misassignment in high-resolution MS

Structural Analogue of Target Analyte
• Ideal internal standard for quantitative methods
• Equivalent physicochemical behavior under chromatographic conditions
• Supports consistent retention times and ionization efficiencies

Validated Quality Control
• Supplied with Certificates of Analysis (CoA)
• Rigorous identity and purity assessment by NMR, MS, and HPLC
• Batch traceability for regulated environments

Enhanced Quantitative Performance
• Improved correction for matrix effects
• Superior compensation for sample preparation variability
• Enables robust standard curves with greater linearity

Custom Labeling Options (where available)
• Deuterium labeling optimized to avoid metabolic exchange
• Alternative isotopic forms upon request subject to feasibility

APPLICATIONS  of  Deuterated (4-Chlorophenyl-4′-hydroxyphenyl)-d8 sulfone

Analytical Reference Standard (LC-MS/MS / GC-MS)
Deuterated (4-Chlorophenyl-4′-hydroxyphenyl)-d₈ sulfone is primarily utilized as an internal standard in quantitative mass spectrometry assays due to its close mimicry of the native analyte. Its stable isotopic signature allows for unambiguous distinction from endogenous or sample-derived molecules, enhancing both selectivity and sensitivity.

Pharmaceutical Bioanalysis
In pharmacokinetic and toxicological studies, this deuterated sulfone standard enables precise quantitation of parent compounds or metabolites in plasma, urine, or tissue. It supports regulatory compliance by reducing analytical uncertainty and is often incorporated into validated methods submitted to regulatory authorities.

Environmental and Forensic Testing
Analytical laboratories performing trace-level detection of phenolic or chlorinated compounds in environmental matrices benefit from using this heavy labeled standard to correct for extraction inefficiencies and instrumental variability.

Method Development and Validation
Scientific teams developing new analytical assays rely on deuterated standards like this sulfone to calibrate instruments, assess linearity, reproducibility, limits of detection (LOD), and limits of quantitation (LOQ). They are indispensable in establishing method performance characteristics.

PRODUCT SPECIFICATIONS

*Actual isotopic enrichment provided on Certificate of Analysis.

HANDLING & STORAGE

Proper handling ensures long-term stability and analytical integrity:

• Store in a cool, dry place away from light
• Keep containers tightly closed until use
• Avoid prolonged exposure to moisture
• Use appropriate PPE (lab coat, gloves, eye protection)

Refer to the Safety Data Sheet (SDS) associated with this product for detailed hazard and emergency information.

QUALITY ASSURANCE

At ResolveMass Laboratories Inc., every batch undergoes extensive quality control including:

• Quantitative NMR (qNMR) for content verification

• Mass spectrometric confirmation of isotopic distribution

• Chromatographic purity assessment (HPLC/UPLC)

Documentation includes a CoA with retention time, purity, and isotopic specification to support laboratory record keeping and compliance requirements.

ORDERING INFORMATION

Deuterated (4-Chlorophenyl-4′-hydroxyphenyl)-d₈ sulfone is available in multiple package sizes tailored to research and industrial needs. Custom packaging, documentation, and support are available upon request.

For pricing, lead times, and material inquiries, please contact our technical sales team or visit resolvemass.ca.

Learn more about Deuterated Chemicals through,

• Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends
• Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 
• ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States.
• Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 
• How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 
• How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 
• Deuterium-Labelled Compounds — Synthesis, Applications & Ordering 
• Custom Synthesis of Deuterated Chemicals