Deuterated 4-Methylstyrene-d10

OVERVIEW

Deuterated 4-Methylstyrene-d10 is a fully isotopically labeled analog of 4-methylstyrene in which all hydrogen atoms are replaced with deuterium (²H). This substitution results in a predictable molecular mass increase of +10 Da compared to the non-deuterated compound, while maintaining nearly identical chemical and chromatographic behavior. Because of these properties, 4-Methylstyrene-d10 is widely used as a stable isotope-labeled internal standard for quantitative analytical applications.

At ResolveMass Laboratories Inc., our Deuterated 4-Methylstyrene-d10 is manufactured with high isotopic enrichment and verified purity to meet the rigorous demands of research, pharmaceutical, environmental, and industrial laboratories. The compound is supplied with full analytical documentation to ensure confidence in traceability, performance, and regulatory compliance.

CHEMICAL INFORMATION

• Chemical Name: 4-Methylstyrene-d10

• Molecular Formula: C₉D₁₀

• Molecular Weight: ~128.24 g/mol

• Isotopic Enrichment: ≥98 atom % D

• Chemical Purity: ≥98%

• Physical Form: Clear, colorless to pale liquid

The complete replacement of hydrogen with deuterium ensures a stable isotopic profile and a well-defined mass shift, making this material particularly valuable for mass spectrometry-based applications. Despite isotopic substitution, its physicochemical behavior remains closely aligned with the unlabeled compound, allowing co-elution or near-identical retention characteristics in chromatographic systems.

APPLICATIONS  of  Deuterated 4-Methylstyrene-d10 

Internal Standard for Mass Spectrometry
Deuterated 4-Methylstyrene-d10 is primarily used as an internal standard in GC-MS and LC-MS methods. The +10 mass shift enables selective monitoring without interference from native analytes. Because the compound behaves almost identically to its non-deuterated counterpart during extraction, separation, and ionization, it effectively compensates for matrix effects, signal suppression, and instrument variability.

Isotope Dilution Quantification
In isotope dilution mass spectrometry (IDMS), accurate quantification depends on the use of structurally identical isotopically labeled standards. 4-Methylstyrene-d10 provides precise correction for sample preparation losses and analytical variability, supporting highly accurate and reproducible quantitation.

Method Development and Validation
Analytical laboratories rely on deuterated standards during calibration curve preparation, recovery studies, precision testing, and robustness assessments. This compound is suitable for method development workflows requiring high specificity and confidence in trace-level detection.

Environmental and Industrial Monitoring
For monitoring styrene derivatives or related aromatic compounds in environmental or industrial matrices, Deuterated 4-Methylstyrene-d10 provides a reliable reference point for quantitative analysis and quality assurance.

Research and Tracer Studies
In research settings, isotopically labeled compounds are valuable tools for studying reaction mechanisms, degradation pathways, and transformation processes. The stable incorporation of deuterium allows differentiation between introduced standards and endogenous compounds.

ANALYTICAL PERFORMANCE

Mass Spectrometry (MS):
The defined +10 Da shift allows clear separation of analyte and internal standard signals. This ensures accurate peak integration and quantification, even in complex matrices.

Chromatography:
Retention time closely matches the non-labeled compound, supporting reliable co-elution in both gas and liquid chromatography systems.

NMR Characteristics:
Deuterium substitution reduces proton signal interference in ¹H NMR, offering simplified spectral interpretation when required for structural verification.

QUALITY ASSURANCE

ResolveMass Laboratories Inc. ensures strict quality control throughout synthesis, purification, and final product verification. Each batch of Deuterated 4-Methylstyrene-d10 undergoes comprehensive analytical testing to confirm:

• High isotopic enrichment (≥98 atom % D)

• High chemical purity (≥98%)

• Minimal residual non-deuterated content

• Confirmed identity via spectroscopic and chromatographic methods

Certificates of Analysis (CoA) are available to support documentation, regulatory submissions, and internal quality systems. Our manufacturing and analytical processes are designed to meet the expectations of advanced analytical laboratories.

WHY CHOOSE RESOLVEMASS LABORATORIES INC.

ResolveMass Laboratories Inc. specializes in high-purity deuterated standards tailored for advanced analytical workflows. Our expertise in isotopic labeling, purification, and mass spectrometry verification ensures reliable performance for quantitative applications. We focus on precision, documentation integrity, and consistent batch-to-batch quality to support demanding research and industrial environments.

Learn more about Deuterated Chemicals through,

• Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends
• Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 
• ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States.
• Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 
• How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 
• How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 
• Deuterium-Labelled Compounds — Synthesis, Applications & Ordering 
• Custom Synthesis of Deuterated Chemicals