Deuterated 4,4′-Bis(chlorophenyl)-d8 sulfone

Overview

Deuterated 4,4′-Bis(chlorophenyl)-d8 sulfone is a stable, high-purity isotopically labeled compound in which the aromatic hydrogen atoms of the parent 4,4′-bis(chlorophenyl) sulfone (commonly known as Dichlorodiphenyl sulfone or 4,4′-Dichlorodiphenyl sulfone) are replaced with deuterium (D, heavy hydrogen). The result is a fully deuterated analog with eight deuterium atoms, typically denoted as d8. This compound is an essential analytical reference standard in mass spectrometry, nuclear magnetic resonance (NMR), and other high-precision analytical methodologies.

Key Features & Distinguishing Attributes

• Isotopic Purity: High deuteration level (≥98% D incorporation) ensures minimal proton interference, delivering clear mass spectral and NMR signatures.

• Chemical Stability: The deuterium substitution increases resistance to metabolic transformation and slows certain degradation pathways.

• Analytical Performance: Minimal isotopic interference improves quantification accuracy and peak resolution in LC-MS, GC-MS, and quantitative NMR (qNMR).

• Application Versatility: Well-suited as an internal standard, calibrant, and tracer in quantitative and qualitative analyses across environmental, pharmaceutical, and forensic laboratories.

Physical & Chemical Properties

Deuterium substitution can induce minor changes in physical properties relative to the protonated parent compound. However, these differences are predictable and well accommodated in analytical method development.

APPLICATIONS & USE CASES  of  Deuterated 4,4′-Bis(chlorophenyl)-d8 sulfone

1. Mass Spectrometry (LC-MS/GC-MS)

Deuterated 4,4′-Bis(chlorophenyl)-d8 sulfone is widely used as an internal standard in liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS). Its unique mass shift from isotopic labeling allows for:

• Accurate quantitation by compensating for matrix effects and ion suppression.

• Method calibration across routine and high-throughput workflows.

• Enhanced precision in quantitative analysis of trace levels in biological and environmental samples.

Because the deuterium atoms increase the compound’s mass without significantly altering its chromatographic behavior, it co-elutes with the analyte of interest providing near-identical recovery characteristics.

2. NMR Spectroscopy

Used as a reference standard in 1H/2H NMR, the deuterated compound shows reduced proton signals and well-resolved spectra. It serves to:

• Minimize background peaks, improving identification of minor components.

• Support quantitative NMR (qNMR) calibrations when combined with other standards.

Deuterated NMR standards are essential for structural elucidation, impurity profiling, and detailed molecular characterization.

3. Environmental & Forensic Analysis

In environmental monitoring and forensic applications, deuterated internal standards like the d8 sulfone enable:

• Trace level detection of chlorinated sulfone contaminants.

• Reliable quantitation in complex matrices (soil, water, human fluids).

• Chain of custody documentation using stable isotope labeling.

4. Pharmaceutical Research

While not typically a drug substance itself, this deuterated standard is invaluable in pharmaceutical R&D for:

• Method validation in ADME and metabolic stability studies.

• Internal calibration in quantitation of related chlorinated compounds.

• Supporting regulatory compliance through validated analytical techniques.

ANALYTICAL CERTIFICATION & TRACEABILITY

ResolveMass Laboratories Inc. supplies Deuterated 4,4′-Bis(chlorophenyl)-d8 sulfone with complete analytical documentation, including:

• Certificate of Analysis (COA) with isotopic and chemical purity data.

• Structural confirmation via NMR and MS spectra.

• Batch traceability and stability data.

Such specifications ensure confidence for use in regulated environments (e.g., GLP, ISO) and strict quality assurance laboratories.

WHY CHOOSE OUR Deuterated 4,4′-Bis(chlorophenyl)-d8 sulfone?

At ResolveMass Laboratories Inc., our isotopically labeled standards are:

• Produced under rigorous quality control.

• Formulated for analytical purity and consistency.

• Backed by comprehensive documentation.

• Supported by technical expertise for application guidance.

Whether for LC-MS quantitation, NMR calibration, or method validation, our deuterated standards are trusted by analytical laboratories worldwide.

Learn more about Deuterated Chemicals through,

• Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends
• Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 
• ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States.
• Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 
• How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 
• How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 
• Deuterium-Labelled Compounds — Synthesis, Applications & Ordering 
• Custom Synthesis of Deuterated Chemicals