Deuterated Ethyl-d5 acrylate | CAS 35717-06-7

OVERVIEW

Deuterated Ethyl-d5 acrylate | CAS 35717-06-7 is a stable isotope–labeled acrylate ester in which five hydrogen atoms are replaced by deuterium (D). This isotopic substitution preserves the native chemical backbone of ethyl acrylate while enhancing its value for analytical, mechanistic, and materials science applications. With its reactive α,β-unsaturated carbonyl system, this monomer serves as a critical tool for kinetic tracing, polymerization studies, and structure–property correlation research across pharmaceuticals, coatings, and polymer science.

ResolveMass Laboratories Inc. provides high-purity Deuterated Ethyl-d5 Acrylate suitable for LC–MS, GC–MS, NMR, polymerization research, and isotopic internal standard development. Its precision isotopic enrichment ensures consistent analytical performance and reproducible behavior in advanced research workflows.

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CHEMICAL INFORMATION

• Chemical Name: Deuterated Ethyl-d5 Acrylate

• Molecular Formula: C5H(D5)7O2

• CAS Number: 35717-06-7

• Category: Deuterated monomer; stable isotope–labeled acrylate

• Functional Groups: Acrylate ester, α,β-unsaturated carbonyl

• Isotopic Label: d5 substitution on the ethyl group

• Typical Purity: ≥ 98% (varies by supplier/specification)

The selective placement of deuterium atoms on the ethyl segment retains the electrophilic acrylate moiety, enabling the compound to participate in free-radical polymerization, Michael additions, and surface-grafting reactions without altering fundamental reactivity. This makes Deuterated Ethyl-d5 Acrylate particularly valuable when researchers require isotopic tagging without modifying functional behavior.

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KEY FEATURES & BENEFITS

1. Stable Isotopic Labeling (d5):
   Ensures clear mass spectral separation, providing robust quantification and tracking in MS-based workflows.

2. Mechanistic Insight in Polymerization:
   Deuterium kinetic isotope effects (KIE) assist in understanding radical propagation, chain-transfer mechanisms, and polymer microstructure formation.

3. High Purity for Analytical Applications:
   Suitable for sensitive LC–MS/GC–MS studies requiring minimal interference or hydrogen/deuterium scrambling.

4. Structural Consistency with Native Monomer:
   Maintains the reactivity profile of ethyl acrylate, enabling its use in comparative studies, polymer performance assessments, and labeled copolymer synthesis.

5. Versatility Across Research Fields:
   Widely used in pharmaceuticals, coatings, adhesives, and biomaterials research, particularly in environments requiring precise isotopic tracing.

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APPLICATIONS  of  Deuterated Ethyl-d5 acrylate | CAS 35717-06-7

1. Mass Spectrometry Internal Standards
Deuterated Ethyl-d5 Acrylate serves as a dependable internal standard in GC-MS and LC-MS workflows. Its mass shift relative to unlabeled ethyl acrylate allows for precise quantitation in impurity analyses, monomer monitoring, and polymer degradation studies.

2. Polymerization Mechanism Studies
The compound is frequently used to probe reaction kinetics in radical polymerization, ATRP, RAFT, and photopolymerization. Researchers leverage isotopic substitution to analyze propagation rate variations, chain-transfer pathways, and polymer microstructure development.

3. Labeled Copolymer Synthesis
Deuterated monomers such as Ethyl-d5 Acrylate are incorporated into copolymers to provide contrast in NMR, neutron scattering, and surface-grafting experiments. The deuterium label enhances signal resolution, enabling fine characterization of polymer domains, swelling behavior, and block copolymer self-assembly.

4. Reaction Tracing & Material Mapping
In surface science, the labeled acrylate is used for mapping reaction zones, deposition patterns, or diffusion gradients in thin films and cross-linked networks.

5. Pharmaceutical and Metabolite Studies
Stable isotope monomers can be employed to investigate polymeric excipient degradation or as reference materials when studying acrylate-based impurities or intermediates.

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ANALYTICAL ADVANTAGES

Deuterated Ethyl-d5 Acrylate supports a wide range of analytical workflows:

• NMR Spectroscopy: Enhanced contrast in ^1H, ^2H, and ^13C NMR for structural assignments and polymer backbone quantification.

• Mass Spectrometry: Strong, predictable mass shift improves sensitivity for trace-level measurements.

• Kinetic Studies: Facilitates isotope effect measurements in free-radical reactions, enabling mechanistic modeling.

• Chromatographic Method Development: Serves as a robust reference standard for setting retention times, optimizing separation conditions, and validating quantification methods.

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STABILITY & HANDLING

The acrylate double bond makes the compound reactive and prone to polymerization under heat, light, or in the presence of radical initiators. Researchers should:

• Store under inert atmosphere when possible

• Keep refrigerated

• Avoid prolonged exposure to UV light

• Use inhibitors/stabilizers if long-term storage is required

Proper handling ensures maximum isotopic integrity and functional performance.

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WHY CHOOSE RESOLVEMASS LABORATORIES?

ResolveMass Laboratories Inc. specializes in supplying high-purity, research-grade isotopically labeled chemicals with rigorous quality control. Our Deuterated Ethyl-d5 Acrylate is sourced and verified to meet demanding analytical, pharmaceutical, and materials-science requirements. With application-focused support, consistent quality, and reliable documentation, we help research teams accelerate discovery and enhance reproducibility.

 

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