Deuterated Ethylene-d4 Glycol | CAS 2219-51-4

Deuterated Ethylene-d4 Glycol (CAS 2219-51-4) is a stable isotope-labeled version of ethylene glycol in which four hydrogen atoms are replaced with deuterium (^2H or D). This isotopically enriched compound retains the chemical behavior of conventional ethylene glycol while exhibiting a higher molecular weight, making it an essential material for analytical chemistry, pharmaceutical research, metabolomics, environmental studies, and mass spectrometry applications.

At ResolveMass Laboratories Inc., we supply high-quality deuterated reference materials that meet the demanding requirements of research laboratories, pharmaceutical companies, biotechnology organizations, contract research organizations (CROs), and academic institutions. Our isotope-labeled compounds are manufactured and handled under strict quality standards to ensure exceptional purity, consistency, and analytical performance.

Product Overview

• Product Name: Deuterated Ethylene-d4 Glycol
• CAS Number: 2219-51-4
• Chemical Formula: C₂D₄(OD)₂ (or equivalent isotopic composition depending on labeling specification)
• Molecular Type: Stable isotope-labeled organic compound
• Isotope: Deuterium (^2H)
• Application: Analytical reference standard, internal standard, tracer studies, pharmaceutical research, metabolomics, and method development

Deuterated Ethylene-d4 Glycol provides excellent isotopic stability while closely mimicking the physicochemical properties of native ethylene glycol. These characteristics make it particularly valuable for quantitative analytical techniques where isotopic labeling minimizes matrix effects and improves measurement accuracy.

Key Features

ResolveMass Laboratories Inc. offers Deuterated Ethylene-d4 Glycol with features designed to support advanced analytical workflows:

• High isotopic enrichment for reliable analytical performance
• High chemical purity suitable for research applications
• Excellent stability under recommended storage conditions
• Ideal for LC-MS, GC-MS, and isotope dilution mass spectrometry
• Suitable for pharmaceutical, environmental, forensic, and academic research
• Manufactured under rigorous quality control procedures
• Available in research quantities to accommodate various project requirements

Applications of Deuterated Ethylene-d4 Glycol

Mass Spectrometry Internal Standard

One of the most common applications of Deuterated Ethylene-d4 Glycol is as an internal standard for quantitative mass spectrometry. Because the compound behaves nearly identically to non-labeled ethylene glycol during sample preparation and chromatographic separation, it enables accurate correction for extraction losses, ion suppression, and instrument variability. This results in improved reproducibility and greater confidence in quantitative analyses.

Pharmaceutical Research and Development

Pharmaceutical scientists use isotope-labeled compounds throughout drug development for analytical method validation, impurity profiling, formulation studies, and bioanalytical assay development. Deuterated Ethylene-d4 Glycol supports robust analytical methods by providing precise quantification during validation and routine testing.

Metabolic and Tracer Studies

Stable isotope-labeled compounds are widely used to investigate metabolic pathways and biochemical transformations. Deuterated Ethylene-d4 Glycol can serve as a tracer in metabolism studies, helping researchers understand molecular transport, degradation pathways, and biological fate without introducing radioactive isotopes.

Environmental Monitoring

Ethylene glycol is commonly encountered in industrial processes, antifreeze formulations, and manufacturing operations. Deuterated Ethylene-d4 Glycol serves as an analytical reference material for monitoring environmental samples, enabling highly accurate detection and quantification of ethylene glycol in complex matrices such as water, soil, and industrial waste.

Method Development and Validation

Analytical laboratories developing new chromatographic or mass spectrometric methods rely on isotope-labeled standards to optimize accuracy and precision. Deuterated Ethylene-d4 Glycol is valuable during method development, calibration curve preparation, recovery studies, and validation according to regulatory expectations.

Benefits of Stable Isotope Labeling

Stable isotope labeling offers several advantages over conventional analytical standards:

• Improved quantitative accuracy
• Better correction for sample preparation variability
• Compensation for matrix effects in LC-MS and GC-MS analyses
• Enhanced method robustness
• Reliable identification of analytes in complex biological and environmental samples
• Non-radioactive and safe for routine laboratory use

These advantages have made deuterated compounds indispensable tools across pharmaceutical, biotechnology, food safety, clinical research, and environmental testing laboratories.

Quality You Can Trust

At ResolveMass Laboratories Inc., quality is central to every product we manufacture and supply. Our Deuterated Ethylene-d4 Glycol undergoes stringent quality assessment to ensure it meets demanding research specifications. Each batch is carefully evaluated for identity, isotopic enrichment, and chemical purity before release.

Researchers depend on consistent reference materials to produce reproducible analytical data, and our commitment to quality helps support reliable scientific outcomes across a wide range of applications.

Why Choose ResolveMass Laboratories Inc.?

ResolveMass Laboratories Inc. specializes in stable isotope-labeled compounds, analytical standards, pharmaceutical reference materials, and custom synthesis services. Our experienced scientific team understands the evolving needs of analytical laboratories and provides products that support cutting-edge research and regulatory compliance.

Customers choose ResolveMass because of our:

• Expertise in stable isotope chemistry
• High-quality analytical reference materials
• Reliable product consistency
• Responsive technical support
• Flexible research-scale supply options
• Commitment to scientific excellence
• Fast and dependable customer service

Whether your laboratory is developing analytical methods, performing quantitative mass spectrometry, conducting pharmaceutical research, or supporting environmental investigations, ResolveMass Laboratories Inc. delivers isotope-labeled compounds designed to meet your research objectives.

Research Use

Deuterated Ethylene-d4 Glycol (CAS 2219-51-4) is intended for research and laboratory applications. It is commonly used in analytical chemistry, pharmaceutical development, metabolomics, environmental analysis, isotope dilution techniques, and scientific investigations requiring highly accurate quantitative measurements.

For product specifications, technical documentation, availability, or custom isotope-labeling requirements, contact ResolveMass Laboratories Inc. Our team is committed to providing premium stable isotope-labeled compounds that support innovative research and analytical excellence worldwide.

Learn more about Deuterated Chemicals through,

• Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends
• Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 
• ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States.
• Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 
• How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 
• How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 
• Deuterium-Labelled Compounds — Synthesis, Applications & Ordering 
• Custom Synthesis of Deuterated Chemicals