Deuterated Ethylene-d6 Glycol | CAS 15054-86-1

Deuterated Ethylene-d6 Glycol (CAS 15054-86-1) is a stable isotope-labeled form of ethylene glycol in which six hydrogen atoms are replaced with deuterium (^2H or D). This isotopically enriched compound maintains nearly identical chemical properties to conventional ethylene glycol while exhibiting a higher molecular weight, making it an indispensable tool for analytical chemistry, pharmaceutical research, metabolomics, forensic science, and environmental studies.

At ResolveMass Laboratories Inc., we provide high-quality deuterated reference standards and isotope-labeled compounds that support accurate quantitative analysis, method development, instrument calibration, and research applications using advanced mass spectrometry and nuclear magnetic resonance (NMR) techniques.

Product Overview

Deuterated Ethylene-d6 Glycol is widely used as an internal standard because its isotopic label allows it to behave chemically like native ethylene glycol while remaining distinguishable during mass spectrometric analysis. The deuterium atoms create a predictable mass shift that enables precise identification and quantification without affecting chromatographic performance.

This compound is particularly valuable for laboratories performing validated analytical methods where accuracy, reproducibility, and sensitivity are critical.

Key Features

• Stable isotope-labeled ethylene glycol
• CAS Number: 15054-86-1
• Six deuterium atoms incorporated into the molecular structure
• Excellent isotopic purity for analytical applications
• Suitable for LC-MS/MS, GC-MS, HRMS, and NMR studies
• Ideal internal standard for quantitative analysis
• High chemical stability under recommended storage conditions
• Manufactured to support research and laboratory applications

Applications of Deuterated Ethylene-d6 Glycol

Internal Standard for Mass Spectrometry

One of the primary applications of Deuterated Ethylene-d6 Glycol is as an internal standard in mass spectrometry-based quantitative analysis. Because the labeled compound behaves almost identically to native ethylene glycol during sample preparation and chromatographic separation, it effectively compensates for variability arising from extraction efficiency, matrix effects, ion suppression, and instrument fluctuations.

The result is significantly improved quantitative accuracy and reproducibility across analytical workflows.

Pharmaceutical Research

Pharmaceutical laboratories utilize Deuterated Ethylene-d6 Glycol during:

• Drug formulation studies
• Residual solvent analysis
• Bioanalytical method validation
• Stability studies
• Quality control testing
• Research involving excipients and formulation components

Its consistent analytical performance makes it valuable throughout pharmaceutical development and regulatory testing.

Toxicology and Clinical Analysis

Ethylene glycol poisoning represents a serious medical emergency requiring rapid and accurate diagnosis. Deuterated Ethylene-d6 Glycol serves as an ideal internal standard for analytical methods used to detect and quantify ethylene glycol in biological samples such as plasma, serum, urine, and other clinical matrices.

Accurate quantification helps support toxicological investigations and clinical laboratory research.

Environmental Monitoring

Environmental laboratories frequently analyze ethylene glycol contamination in:

• Surface water
• Groundwater
• Industrial wastewater
• Soil extracts
• Environmental monitoring samples

Using a deuterated internal standard improves analytical confidence while minimizing errors caused by complex environmental matrices.

Metabolomics Research

Stable isotope-labeled compounds play an important role in metabolomics workflows. Deuterated Ethylene-d6 Glycol enables researchers to improve metabolite quantification, validate analytical methods, and distinguish target analytes from endogenous background signals.

Its isotope label provides enhanced confidence in compound identification using high-resolution mass spectrometry.

NMR Applications

The deuterium labeling also makes this compound useful for specialized NMR experiments. Researchers may use Deuterated Ethylene-d6 Glycol for instrument calibration, solvent studies, isotope-labeling investigations, and structural characterization.

Advantages of Using Deuterated Standards

Stable isotope-labeled reference materials have become the gold standard for quantitative analytical chemistry because they closely mimic the behavior of native analytes while remaining distinguishable by mass spectrometry.

The benefits include:

• Improved analytical accuracy
• Better precision across replicate analyses
• Compensation for sample preparation losses
• Reduced matrix effects
• Enhanced method robustness
• Reliable instrument calibration
• Increased confidence in quantitative results
• Simplified method validation

These advantages are particularly important in regulated pharmaceutical and bioanalytical laboratories.

Analytical Techniques

Deuterated Ethylene-d6 Glycol is compatible with numerous analytical platforms, including:

• Liquid Chromatography–Mass Spectrometry (LC-MS/MS)
• Gas Chromatography–Mass Spectrometry (GC-MS)
• High-Resolution Mass Spectrometry (HRMS)
• Nuclear Magnetic Resonance (NMR)
• Isotope dilution mass spectrometry (IDMS)
• Quantitative analytical workflows

Its versatility makes it suitable for both routine laboratory testing and advanced research applications.

Quality and Manufacturing

At ResolveMass Laboratories Inc., quality is a central focus in the production and supply of isotope-labeled reference materials. Every batch undergoes rigorous quality assessment to help ensure identity, isotopic enrichment, purity, and consistency.

Our analytical expertise supports researchers working in pharmaceutical development, biotechnology, academia, contract research, and analytical laboratories by providing dependable isotope-labeled compounds that meet demanding research requirements.

Storage Recommendations

For optimal stability, Deuterated Ethylene-d6 Glycol should be stored according to the recommendations provided with the product. Proper storage helps preserve isotopic integrity and maintain long-term analytical performance.

Users should avoid repeated freeze-thaw cycles where applicable and minimize exposure to moisture or contaminants during handling.

Why Choose ResolveMass Laboratories Inc.?

ResolveMass Laboratories Inc. specializes in isotope-labeled compounds, analytical reference standards, and custom synthesis solutions for laboratories worldwide. Our team combines scientific expertise with stringent quality standards to deliver products that support reliable analytical results.

By choosing ResolveMass, customers benefit from:

• High-quality stable isotope-labeled compounds
• Consistent product quality
• Technical expertise in analytical chemistry
• Support for pharmaceutical and life science research
• Reliable supply for research and development projects
• Commitment to scientific excellence and customer satisfaction

Whether your laboratory is developing new analytical methods, validating quantitative assays, conducting toxicology studies, or performing advanced metabolomics research, Deuterated Ethylene-d6 Glycol (CAS 15054-86-1) provides the accuracy and reliability needed for high-performance analytical applications.

Learn more about Deuterated Chemicals through,

• Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends
• Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 
• ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States.
• Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 
• How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 
• How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 
• Deuterium-Labelled Compounds — Synthesis, Applications & Ordering 
• Custom Synthesis of Deuterated Chemicals