Deuterated Isopropyl-d7-amine (CAS 106658-09-7)

Deuterated Isopropyl-d7-amine | CAS 106658-09-7, also known as Isopropyl-d7-amine or 2-Aminopropane-d7, is a stable isotope-labeled analog of isopropylamine in which seven hydrogen atoms are replaced with deuterium (²H). This isotopically enriched compound is extensively used in pharmaceutical research, analytical chemistry, bioanalytical method development, metabolite identification, and quantitative LC-MS/MS and GC-MS applications. The deuterium substitution provides a predictable mass shift while maintaining chemical properties nearly identical to the non-labeled compound, making it an ideal internal standard and tracer for highly accurate quantitative analysis.

ResolveMass Laboratories Inc. supplies high-quality isotope-labeled reference standards designed to meet the demanding requirements of pharmaceutical companies, CROs, academic institutions, and analytical laboratories worldwide. Our deuterated compounds are manufactured under rigorous quality standards to ensure excellent isotopic enrichment, purity, and reproducibility.

Chemical Information

Product Name: Deuterated Isopropyl-d7-amine

CAS Number: 106658-09-7

Synonyms:

• Isopropyl-d7-amine
• 2-Aminopropane-d7
• 1,1,1,2,3,3,3-Heptadeuteriopropan-2-amine

Molecular Formula: C₃H₂D₇N

Molecular Weight: 66.15 g/mol

Mass Shift: M+7

Linear Formula: CD₃CD(NH₂)CD₃

Product Overview

Deuterated Isopropyl-d7-amine belongs to the family of stable isotope-labeled primary amines used extensively as analytical reference materials. Because the deuterium atoms replace hydrogen without significantly changing the compound’s chemical behavior, the labeled molecule closely mimics the chromatographic retention, extraction efficiency, and reaction characteristics of native isopropylamine.

The primary distinction between the labeled and unlabeled compound is the increased molecular mass, allowing analytical instruments such as LC-MS/MS, GC-MS, and HRMS to distinguish the internal standard from endogenous or sample-derived analytes with exceptional precision.

This characteristic significantly improves quantitative accuracy by correcting for variations during sample preparation, extraction, ionization efficiency, and instrument performance.

Applications:

LC-MS/MS Internal Standard

Deuterated Isopropyl-d7-amine is widely employed as an internal standard during quantitative LC-MS/MS assays. Stable isotope-labeled internal standards compensate for matrix effects and analytical variability, resulting in improved accuracy and precision across complex biological and pharmaceutical samples.

GC-MS Analysis

The compound is suitable for gas chromatography-mass spectrometry workflows where isotopic labeling enables reliable differentiation between analyte and internal standard while maintaining similar chromatographic behavior.

Pharmaceutical Research

Researchers utilize Isopropyl-d7-amine during drug discovery and pharmaceutical development for:

• Quantitative bioanalysis
• Pharmacokinetic studies
• Drug metabolism investigations
• Impurity profiling
• Method validation
• Analytical method transfer

Stable Isotope Tracing

Because the molecule contains seven deuterium atoms, it serves as an excellent tracer for studying chemical transformations, synthetic pathways, reaction mechanisms, and isotope distribution without introducing radioactivity.

Method Development and Validation

Analytical laboratories routinely employ isotope-labeled compounds to validate methods according to regulatory expectations for:

• Accuracy
• Precision
• Recovery
• Linearity
• Robustness
• Repeatability

Advantages of Using Deuterated Isopropyl-d7-amine

Using an isotope-labeled internal standard offers several analytical benefits:

• Excellent correction for sample preparation losses
• Compensation for ion suppression and matrix effects
• Improved quantitative reproducibility
• Enhanced assay sensitivity
• Greater confidence in regulatory submissions
• Reliable performance across multiple analytical platforms
• Reduced variability between analytical batches

These advantages make deuterated standards indispensable for modern pharmaceutical bioanalysis and regulated laboratory environments.

Analytical and Research Uses

Deuterated Isopropyl-d7-amine is commonly incorporated into workflows involving:

• LC-MS/MS quantitative assays
• GC-MS method development
• High-resolution mass spectrometry (HRMS)
• Pharmaceutical impurity analysis
• Metabolite identification
• Bioanalytical assay development
• Reference standard preparation
• Stable isotope dilution analysis
• Analytical quality control
• Chemical synthesis research

The compound is also valuable for laboratories developing highly sensitive analytical methods that require precise quantitation over broad concentration ranges.

Why Stable Isotope Labeling Matters

Stable isotope-labeled compounds have become the gold standard for quantitative mass spectrometry. Since deuterium is a naturally occurring, non-radioactive isotope of hydrogen, deuterated analogs exhibit nearly identical chemical properties to their unlabeled counterparts while remaining distinguishable by mass spectrometry.

This unique property minimizes analytical bias and enables highly reliable quantification, especially in complex biological matrices where matrix effects can otherwise compromise assay performance.

Quality at ResolveMass Laboratories Inc.

ResolveMass Laboratories Inc. specializes in supplying high-quality isotope-labeled reference materials for pharmaceutical and analytical applications. Our products are manufactured with strict quality control procedures to ensure:

• High isotopic enrichment
• Excellent chemical purity
• Batch-to-batch consistency
• Reliable analytical performance
• Secure packaging
• Worldwide shipment

Our isotope-labeled compounds support pharmaceutical companies, contract research organizations, universities, biotechnology companies, and analytical laboratories conducting advanced research and regulated testing.

Order High-Quality Deuterated Isopropyl-d7-amine

ResolveMass Laboratories Inc. is committed to providing premium stable isotope-labeled standards that support pharmaceutical innovation, analytical excellence, and scientific discovery. Whether you require Deuterated Isopropyl-d7-amine for quantitative LC-MS/MS, GC-MS, metabolite studies, or method validation, our products are manufactured to deliver dependable performance and consistent results.

Contact ResolveMass Laboratories Inc. today to learn more about Deuterated Isopropyl-d7-amine (CAS 106658-09-7), custom isotope labeling services, bulk quantities, or additional stable isotope reference standards for your analytical and pharmaceutical research needs.

Learn more about Deuterated Chemicals through,

• Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends
• Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 
• ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States.
• Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 
• How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 
• How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 
• Deuterium-Labelled Compounds — Synthesis, Applications & Ordering 
• Custom Synthesis of Deuterated Chemicals