Deuterated N-isopropyl methacrylamide-d12 | CAS 1219803-32-3

OVERVIEW
ResolveMass Laboratories Inc. offers high-quality Deuterated N-isopropyl methacrylamide-d12 | CAS 1219803-32-3, a stable isotopically labelled analogue of N-isopropyl methacrylamide. This reagent is designed for use in mass spectrometry, quantitative analytical standards, polymer science studies, and tracer experiments where deuterium labelling improves identification, quantitation, or mechanistic understanding. The molecular deuteration (d12) provides an unambiguous mass shift versus the protiated parent compound, facilitating accurate internal standardisation and peak assignment in complex matrices.

CHEMICAL IDENTIFIERS

• CAS: 1219803-32-3

• Synonyms: N-isopropylmethacrylamide-d12; N-IPMAm-d12; Deuterated N-IPMAm

• Empirical description: Isopropyl methacrylamide fully deuterated at exchangeable carbon-bound hydrogens (d12 isotopologue)

CHEMICAL & PHYSICAL PROPERTIES

• Chemical class: Deuterated monomer / isotopically labelled acrylamide analogue

• Typical form: Colorless to pale yellow liquid or low-melting solid (batch dependent)

• Isotopic enrichment: High deuterium incorporation (specified by lot; typical ≥98 atom % D where applicable)

• Purity: High purity suitable for analytical and synthetic use (see Certificate of Analysis for lot-specific data)

• Stability: Chemically stable under recommended storage conditions; avoid prolonged exposure to strong acids or bases that may promote H/D exchange.

APPLICATIONS & USES  of  Deuterated N-isopropyl methacrylamide-d12 | CAS 1219803-32-3

• Mass spectrometry internal standard: Ideal as an internal standard for LC-MS/MS or GC-MS quantitation of N-isopropyl methacrylamide or related polymer degradation products. The +12 Da mass shift simplifies peak discrimination and improves quantitative accuracy.

• Polymer and material science: Useful in mechanistic polymerisation studies, chain-transfer analyses, and labelling experiments to track incorporation and fate of monomer units in copolymers and hydrogels.

• Kinetic and tracer experiments: Enables kinetic isotope effect (KIE) studies and tracer experiments where deuterium labelling modulates reaction rates or enables tracing in complex reaction networks.

• Analytical method development: Serves as a reference standard for method validation, limit of detection/quantitation studies, and matrix spike recovery experiments.

• Research & development: Employed in pharmaceutical formulation studies (e.g., labelled monomer tracing in drug-loaded polymers), academic research, and industrial R&D requiring isotopically labelled monomers.

ANALYTICAL CHARACTERISATION
Each lot of N-IPMAm-d12 is accompanied by a Certificate of Analysis (CoA) containing:

• GC/GC-MS or LC-MS confirmation of molecular ion and isotopic pattern

• 1H/2H NMR or other NMR data confirming deuterium incorporation where applicable

• Purity by GC/LC and/or qNMR (lot-specific)

• Water content (Karl Fischer) and residual solvents (where applicable)
  Customers requiring additional analytical specifications (e.g., exact atom % D, impurity profiling, or custom testing) may request tailored documentation prior to purchase.

HANDLING & STORAGE

• Store tightly capped in a cool, dry place, away from direct sunlight and moisture. Recommended storage at 2–8°C for long-term stability; short-term storage at ambient conditions is acceptable if container integrity is maintained.

• Minimise exposure to protic solvents and acidic/basic conditions to reduce the potential for H/D exchange. Use anhydrous solvents for reactions where retention of deuterium labelling is critical.

• Handle with appropriate laboratory PPE: gloves, eye protection, and lab coat. Work in a well-ventilated area or fume hood.

SAFETY INFORMATION

• Standard laboratory safety practices apply. Avoid ingestion, inhalation, and skin contact. Consult the supplied Safety Data Sheet (SDS) for full hazard, first-aid, and disposal information.

• Deuterated compounds retain the chemical hazards of their protiated analogues; isotopic substitution does not eliminate toxicity or flammability hazards inherent to the molecular scaffold.

CUSTOMISATION & AVAILABILITY
ResolveMass Laboratories can supply bespoke quantities and purities to meet research and production needs. We provide lot-specific Certificates of Analysis and can discuss packaging formats that suit experimental workflows. Contact our technical sales team for quotations on bulk supply, custom isotopic enrichment levels, or specialised documentation.

WHY CHOOSE RESOLVEMASS
ResolveMass Laboratories Inc. combines rigorous quality control with responsive customer support. Our deuterated standards are produced and analysed to meet the stringent demands of analytical chemists, polymer scientists, and pharmaceutical developers. We prioritise traceability, certificate accuracy, and stable supply — enabling reproducible science and robust method development.

TECHNICAL SUPPORT
For technical questions, custom requests (including alternative isotopic labelling patterns), or to request the latest Certificate of Analysis for a specific lot, please contact ResolveMass technical support. Our team can advise on storage, recommended solvents to avoid H/D exchange, and suitability for your intended analytical workflow.

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