Deuterated Phenol-d6 | CAS 13127-88-3

Product Name: Deuterated Phenol-d6
CAS Number: 13127-88-3
Molecular Formula: C₆D₆O
Molecular Weight: 100.16 g/mol

Overview

Deuterated Phenol-d6 (CAS 13127-88-3) is a stable isotope-labeled analog of phenol in which all six aromatic hydrogen atoms are replaced with deuterium. This isotopically enriched compound retains the chemical properties of native phenol while exhibiting a distinct mass shift, making it an ideal internal standard, analytical reference material, and tracer compound for quantitative mass spectrometry applications.

Phenol-d6 is widely used in pharmaceutical, environmental, forensic, food safety, and academic research laboratories for accurate quantification of phenolic compounds. Its excellent isotopic purity and chemical stability enable highly reliable results in LC-MS/MS, GC-MS, GC-MS/MS, and high-resolution mass spectrometry (HRMS) analyses. By compensating for sample preparation losses, ionization variability, and matrix effects, Deuterated Phenol-d6 improves analytical precision and supports robust method validation.

Applications:

Pharmaceutical Bioanalysis

Phenol-d6 serves as an internal standard during the quantitative analysis of phenol and structurally related compounds in pharmaceutical formulations, biological matrices, and impurity profiling studies. Stable isotope labeling minimizes analytical variability, leading to improved reproducibility and regulatory-compliant data generation.

Environmental Monitoring

Environmental laboratories utilize Deuterated Phenol-d6 for monitoring phenolic contaminants in groundwater, wastewater, drinking water, industrial effluents, and soil samples. It assists in achieving accurate recovery corrections during sample extraction and instrumental analysis.

Food and Beverage Testing

Phenolic compounds may occur naturally or as contaminants in food products and packaging materials. Phenol-d6 provides reliable quantitative calibration for analytical methods used in food safety testing, helping laboratories achieve consistent and reproducible measurements.

Forensic and Toxicology Analysis

Forensic laboratories employ isotopically labeled internal standards to ensure precise quantification of target analytes. Deuterated Phenol-d6 enhances analytical accuracy when determining phenolic compounds in biological specimens and complex forensic samples.

Research and Method Development

Researchers use Phenol-d6 in isotope dilution mass spectrometry (IDMS), analytical method development, instrument calibration, metabolic investigations, and chemical tracer studies. Its predictable chromatographic behavior closely matches that of unlabeled phenol while remaining distinguishable by mass spectrometry.

Key Features

• Stable isotope-labeled phenol containing six deuterium atoms
• CAS Number: 13127-88-3
• Suitable for LC-MS/MS, GC-MS, GC-MS/MS, and HRMS workflows
• Excellent internal standard for quantitative isotope dilution analysis
• High isotopic enrichment for reliable analytical performance
• Comparable chromatographic retention to native phenol
• Improves analytical precision by correcting matrix effects and extraction losses
• Ideal for regulated pharmaceutical, environmental, food, and research laboratories

Benefits of Using Deuterated Phenol-d6

Using a stable isotope-labeled internal standard is considered one of the most effective approaches for improving quantitative analytical performance. Deuterated Phenol-d6 closely mimics the physicochemical behavior of native phenol throughout extraction, chromatography, and ionization while remaining distinguishable by its unique mass. This allows laboratories to compensate for variations introduced during sample preparation and instrumental analysis.

The use of Phenol-d6 contributes to:

• Improved quantitative accuracy
• Enhanced method reproducibility
• Reduced matrix interference
• Better recovery correction
• Increased confidence in regulatory submissions
• Consistent performance across multiple analytical batches

Analytical Techniques

Deuterated Phenol-d6 is compatible with numerous analytical platforms, including:

• Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS)
• Gas Chromatography–Mass Spectrometry (GC-MS)
• Gas Chromatography–Tandem Mass Spectrometry (GC-MS/MS)
• High-Resolution Mass Spectrometry (HRMS)
• Isotope Dilution Mass Spectrometry (IDMS)
• Analytical method validation and calibration studies

Quality and Manufacturing

ResolveMass Laboratories Inc. is committed to supplying high-quality isotope-labeled reference standards that meet the demanding requirements of analytical laboratories worldwide. Each batch of Deuterated Phenol-d6 is manufactured and quality tested to ensure high chemical purity, isotopic enrichment, identity confirmation, and consistent analytical performance. Comprehensive quality documentation is available to support research, pharmaceutical development, environmental testing, and quality control applications.

Why Choose ResolveMass Laboratories Inc.?

ResolveMass Laboratories Inc. provides high-quality stable isotope-labeled compounds designed to support advanced analytical testing across pharmaceutical, biotechnology, environmental, food safety, forensic, and academic research laboratories. Our products are manufactured with stringent quality standards and are suitable for demanding quantitative mass spectrometry applications.

Customers benefit from:

• High-quality stable isotope-labeled reference materials
• Consistent batch-to-batch performance
• Reliable analytical standards for quantitative workflows
• Technical expertise in mass spectrometry and analytical chemistry
• Responsive customer support
• Global supply capabilities for research and industrial laboratories

Whether you are developing validated analytical methods, performing environmental monitoring, conducting pharmaceutical impurity analysis, or supporting routine quality control testing, Deuterated Phenol-d6 (CAS 13127-88-3) provides the analytical reliability required for accurate quantitative results.

For product specifications, pricing, bulk quantities, custom isotope-labeled compounds, or technical assistance, contact ResolveMass Laboratories Inc. Our scientific team is available to help identify the most suitable isotope-labeled standards for your analytical and research requirements.

 

Learn more about Deuterated Chemicals through,

• Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends
• Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 
• ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States.
• Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 
• How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 
• How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 
• Deuterium-Labelled Compounds — Synthesis, Applications & Ordering 
• Custom Synthesis of Deuterated Chemicals