Deuterated Propionic-d5 Acid | CAS 60153-92-6

Deuterated Propionic-d5 Acid (Propionic Acid-d5) is a stable isotope-labeled analog of propionic acid in which five hydrogen atoms are replaced with deuterium (²H). With CAS No. 60153-92-6, this compound is widely used as an internal standard for the accurate quantification of propionic acid in complex biological, pharmaceutical, food, environmental, and microbiome samples using LC-MS/MS, GC-MS, and high-resolution mass spectrometry (HRMS). The isotopic substitution produces a predictable mass shift of +5 Da while preserving nearly identical chemical and chromatographic properties to native propionic acid, making it ideal for isotope dilution mass spectrometry.

At ResolveMass Laboratories Inc., we provide high-quality deuterated reference standards to support pharmaceutical research, analytical method development, metabolomics, bioanalysis, clinical research, and regulatory testing laboratories worldwide.

Product Information

• Product Name: Deuterated Propionic-d5 Acid
• CAS Number: 60153-92-6
• Synonyms: Propionic Acid-d5, Propanoic Acid-d5, Propionate-d5
• Molecular Formula: C₃HD₅O₂
• Molecular Weight: 79.11 g/mol
• Mass Shift: +5 Da
• Isotopic Purity: ≥98 atom % D (typical)
• Chemical Purity: ≥99%
• Appearance: Clear liquid/oil
• Solubility: Soluble in water and methanol
• Recommended Storage: -20°C in tightly sealed containers for long-term stability.

Why Use Deuterated Propionic-d5 Acid?

Stable isotope-labeled compounds are essential for achieving reliable quantitative mass spectrometric analysis. During sample preparation, chromatographic separation, ionization, and mass analysis, analyte recovery and instrument response can vary considerably. Deuterated Propionic-d5 Acid compensates for these variations because it behaves almost identically to native propionic acid throughout the analytical workflow while remaining distinguishable by its characteristic mass difference.

This significantly improves analytical precision by correcting for extraction losses, matrix effects, ion suppression, and instrument variability. Consequently, laboratories obtain improved accuracy, reproducibility, sensitivity, and confidence in quantitative results.

Applications:

LC-MS/MS Quantification

Propionic Acid-d5 is extensively used as an internal standard during quantitative LC-MS/MS assays. It enables precise determination of endogenous propionic acid concentrations in plasma, serum, urine, tissues, and cell culture samples.

GC-MS Analysis

Following suitable derivatization, the compound serves as an excellent internal standard for GC-MS analysis of volatile short-chain fatty acids (SCFAs), ensuring robust quantification across diverse sample matrices.

Metabolomics Research

Short-chain fatty acids such as propionate play important roles in host metabolism and gut microbiome function. Deuterated Propionic-d5 Acid supports targeted metabolomics workflows by providing accurate normalization during quantitative analysis.

Pharmaceutical Research

The compound is widely employed during analytical method development, method validation, pharmacokinetic studies, bioanalytical assays, and quality control testing where highly accurate quantification of propionic acid is required.

Food and Nutrition Analysis

Researchers studying fermented foods, dairy products, dietary supplements, and microbial fermentation utilize isotope-labeled propionic acid standards for reliable determination of SCFA concentrations.

Environmental and Microbiome Studies

Environmental scientists and microbiome researchers frequently quantify propionate in soil, wastewater, fermentation systems, and microbial cultures. The use of isotope-labeled internal standards improves analytical confidence even in highly complex matrices.

Advantages of Using Stable Isotope-Labeled Standards

Using Deuterated Propionic-d5 Acid offers numerous analytical benefits, including:

• Improved quantitative accuracy
• Excellent correction for matrix effects
• Compensation for extraction variability
• Reduced analytical bias
• Enhanced assay reproducibility
• Better inter-laboratory consistency
• Simplified regulatory method validation
• Compatibility with isotope dilution mass spectrometry (IDMS)

These advantages make isotope-labeled standards indispensable in modern analytical laboratories operating under GLP, GMP, FDA, EMA, and ICH quality expectations.

Typical Research Areas

Deuterated Propionic-d5 Acid is commonly used in:

• Targeted metabolomics
• Gut microbiome research
• Clinical metabolite profiling
• Pharmaceutical bioanalysis
• Biomarker discovery
• Toxicology studies
• Nutritional science
• Food chemistry
• Environmental monitoring
• Analytical method validation
• Quality control laboratories

Quality You Can Trust

ResolveMass Laboratories Inc. supplies stable isotope-labeled compounds manufactured to rigorous quality standards. Each batch undergoes comprehensive quality evaluation to verify isotopic enrichment, chemical purity, and product identity, supporting reproducible analytical performance across research and industrial applications.

Our experienced analytical scientists also provide expertise in LC-MS/MS method development, metabolomics, bioanalysis, mass spectrometry services, and custom stable isotope applications, enabling customers to integrate isotope-labeled standards into complex analytical workflows.

Why Choose ResolveMass Laboratories Inc.?

Researchers worldwide trust ResolveMass Laboratories Inc. for reliable isotope-labeled reference materials and advanced analytical solutions. We combine scientific expertise with responsive technical support to help pharmaceutical, biotechnology, academic, environmental, and clinical laboratories achieve high-quality analytical data.

Whether you are developing quantitative LC-MS/MS methods, validating bioanalytical assays, conducting metabolomics research, or performing routine quality control, our Deuterated Propionic-d5 Acid provides the accuracy and consistency required for demanding mass spectrometry applications.

For bulk quantities, custom packaging, technical documentation, or assistance selecting the appropriate stable isotope standard for your workflow, contact the ResolveMass Laboratories team. We are committed to supporting your analytical and research needs with high-quality isotope-labeled compounds and expert scientific guidance.

Learn more about Deuterated Chemicals through,

• Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends
• Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 
• ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States.
• Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 
• How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 
• How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 
• Deuterium-Labelled Compounds — Synthesis, Applications & Ordering 
• Custom Synthesis of Deuterated Chemicals