Deuterated Pyridine-d5 (Pyridine-d5) | CAS 7291-22-7

CAS Number: 7291-22-7
Molecular Formula: C₅D₅N
Molecular Weight: 84.13 g/mol
Synonyms: Pyridine-d5, Pentadeuteropyridine, Pyridine-D5, Deuterated Pyridine

High-Purity Deuterated Pyridine-d5 for NMR Spectroscopy and Analytical Research

Deuterated Pyridine-d5 (CAS 7291-22-7) is a premium isotopically labeled solvent widely used in nuclear magnetic resonance (NMR) spectroscopy, pharmaceutical research, organic synthesis, and analytical chemistry. In Pyridine-d5, the five hydrogen atoms of pyridine are replaced with deuterium, significantly reducing proton interference during NMR analysis while providing excellent spectral clarity and solvent stability. It serves as an important deuterated solvent for compounds that exhibit poor solubility in common deuterated solvents such as CDCl₃ or DMSO-d₆ and is especially valuable for analyzing polar molecules, natural products, carbohydrates, peptides, heterocyclic compounds, and pharmaceutical intermediates.

At ResolveMass Laboratories Inc., we supply high-quality Deuterated Pyridine-d5 that meets the demanding requirements of pharmaceutical, biotechnology, academic, and industrial research laboratories. Every batch is manufactured and quality tested to ensure high chemical purity, high isotopic enrichment, and consistent analytical performance for reproducible NMR experiments.

Key Features

• High isotopic enrichment for superior NMR performance
• Excellent chemical purity for analytical applications
• Suitable for ¹H, ¹³C, and multidimensional NMR studies
• Ideal for compounds with limited solubility in conventional deuterated solvents
• Low residual proton content for improved spectral quality
• Reliable batch-to-batch consistency
• Suitable for pharmaceutical, chemical, and academic research laboratories

Applications of Deuterated Pyridine-d5

Pyridine-d5 is extensively used across analytical and pharmaceutical laboratories due to its unique solvent properties. Common applications include:

NMR Spectroscopy

Pyridine-d5 is primarily employed as an NMR solvent for structural elucidation of complex organic molecules. Its deuterium labeling minimizes solvent proton signals while providing a stable lock signal for modern NMR spectrometers. It is particularly useful for compounds requiring strong hydrogen-bond disruption or enhanced solubility.

Pharmaceutical Research

Drug discovery and pharmaceutical development frequently utilize Pyridine-d5 during:

• API characterization
• Impurity identification
• Structure confirmation
• Forced degradation studies
• Process development
• Quality control investigations

Its ability to dissolve challenging pharmaceutical compounds makes it a preferred solvent during analytical method development.

Natural Product Characterization

Many natural products exhibit poor solubility in traditional deuterated solvents. Pyridine-d5 provides improved solubility for:

• Alkaloids
• Glycosides
• Flavonoids
• Steroids
• Peptides
• Carbohydrates

This enables accurate structural assignments using high-resolution NMR techniques.

Organic Synthesis Research

Synthetic chemists routinely use Pyridine-d5 to characterize newly synthesized compounds, monitor reaction products, and confirm molecular structures during medicinal chemistry and organic synthesis workflows.

Academic and Industrial Research

Universities, government laboratories, CROs, and chemical manufacturers rely on Deuterated Pyridine-d5 for advanced molecular characterization, isotope labeling studies, reaction mechanism investigations, and analytical research projects.

Why Choose Deuterated Pyridine-d5?

Compared with conventional protonated pyridine, the deuterated analogue significantly reduces unwanted proton background signals, allowing researchers to obtain cleaner and more interpretable NMR spectra. Its excellent solvating ability makes it one of the preferred deuterated solvents for difficult-to-dissolve compounds that cannot be effectively analyzed using chloroform-d, methanol-d₄, or DMSO-d₆.

The solvent also supports advanced NMR experiments including:

• 1D NMR
• 2D NMR
• COSY
• HSQC
• HMBC
• NOESY
• TOCSY
• Quantitative NMR (qNMR)

Researchers benefit from improved signal resolution, reliable spectral interpretation, and enhanced reproducibility during analytical investigations.

Quality and Specifications

High-quality Deuterated Pyridine-d5 typically offers:

• High chemical purity
• High isotopic enrichment (atom % D)
• Low water content
• Low residual proton content
• Excellent stability under recommended storage conditions
• Consistent analytical performance

Commercial analytical grades are commonly supplied with ≥99% chemical purity and high deuterium enrichment suitable for NMR applications.

Industries Served

ResolveMass supports customers across numerous industries, including:

• Pharmaceutical Research
• Biotechnology
• Contract Research Organizations (CROs)
• Chemical Manufacturing
• Academic Research Institutions
• Government Laboratories
• Life Sciences
• Materials Science
• Analytical Testing Laboratories

Why ResolveMass Laboratories Inc.?

ResolveMass Laboratories Inc. is committed to supplying premium research chemicals and analytical materials that meet the rigorous standards of modern scientific research. Our focus on quality, technical expertise, and customer support enables researchers worldwide to achieve reliable and reproducible analytical results.

Whether your laboratory requires Deuterated Pyridine-d5 for pharmaceutical analysis, structural elucidation, impurity profiling, or advanced NMR spectroscopy, ResolveMass delivers products backed by stringent quality standards and dependable service.

Learn more about Deuterated Chemicals through,

• Deuterated Polymers: A Cornerstone Guide to Synthesis, Applications, and Future Trends
• Availability of All the Deuterated Chemicals at ResolveMass Laboratories Inc. 
• ResolveMass Laboratories: Leading Deuterated Chemical Synthesis Company in the United States.
• Deuterated Internal Standards for LC-MS: Selection & Custom Synthesis 
• How to Choose the Right Deuterated Labelled Chemical Synthesis Company in Canada 
• How to Choose the Right Deuterium Labelled Compounds Supplier for Your Lab 
• Deuterium-Labelled Compounds — Synthesis, Applications & Ordering 
• Custom Synthesis of Deuterated Chemicals