Deuterated Sodium Borohydride-d4 (CAS 15681-89-7)

CAS Number: 15681-89-7
Molecular Formula: NaBD₄
Molecular Weight: 41.83 g/mol
Synonyms: Sodium borodeuteride-d4, Sodium tetra(deuterio)borate, NaBD₄, Deuterated Sodium Borohydride

Product Overview

Deuterated Sodium Borohydride-d4 (NaBD₄) is a highly effective deuterium-labeled reducing agent widely used in organic synthesis, medicinal chemistry, isotope labeling, and analytical research. As the deuterated analogue of sodium borohydride (NaBH₄), it selectively transfers deuteride (D⁻) instead of hydride (H⁻), enabling the incorporation of deuterium atoms into organic molecules with excellent precision.

The controlled introduction of deuterium plays an increasingly important role in pharmaceutical research, metabolite identification, isotope tracing, and mass spectrometry studies. Researchers use Sodium Borohydride-d4 to synthesize deuterium-labeled reference standards, investigate reaction mechanisms, and prepare compounds for pharmacokinetic and metabolic studies.

ResolveMass Laboratories Inc. supplies high-quality Deuterated Sodium Borohydride-d4 (CAS 15681-89-7) suitable for research and laboratory applications where isotopic purity, consistency, and reproducibility are essential.

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Chemical Properties

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Principle of Deuterium Reduction

Sodium Borohydride-d4 functions similarly to conventional sodium borohydride but delivers deuteride ions instead of hydride ions during reduction reactions. This allows the selective incorporation of deuterium into target molecules without significantly altering the underlying reaction pathway.

Because deuterium behaves chemically much like hydrogen while possessing a different atomic mass, labeled compounds can easily be distinguished using modern analytical techniques such as LC-MS, GC-MS, and NMR spectroscopy. This makes NaBD₄ an indispensable reagent for preparing isotopically labeled compounds for analytical and pharmaceutical research.

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Applications:

Pharmaceutical Research

Deuterated Sodium Borohydride-d4 is extensively used during pharmaceutical research to prepare stable isotope-labeled drug candidates and reference compounds. These labeled molecules assist scientists in understanding drug metabolism, absorption, distribution, and elimination while supporting bioanalytical method development.

Mass Spectrometry Standards

Stable isotope-labeled compounds synthesized using NaBD₄ serve as internal standards for quantitative LC-MS/MS and GC-MS analyses. Their nearly identical chemical behavior compared to unlabeled analytes enables accurate correction for extraction losses, matrix effects, and instrument variability.

Metabolite Identification

Researchers employ Sodium Borohydride-d4 to generate deuterated metabolites that facilitate metabolite profiling and structural characterization. The predictable mass shift simplifies identification of metabolic pathways during drug development.

Organic Synthesis

NaBD₄ efficiently reduces numerous functional groups, including:

• Aldehydes
• Ketones
• Certain imines
• Selected carbonyl-containing intermediates

The reagent introduces deuterium during reduction, making it valuable for preparing isotopically labeled alcohols and other intermediates used in synthetic chemistry.

Reaction Mechanism Studies

Because deuterium behaves differently from hydrogen in kinetic isotope effect experiments, Sodium Borohydride-d4 helps researchers investigate reaction pathways, transition states, and mechanistic details in organic and organometallic chemistry.

Isotope Labeling

NaBD₄ is widely used for selective incorporation of deuterium into:

• Pharmaceutical intermediates
• Fine chemicals
• Natural products
• Agrochemical compounds
• Research chemicals

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Advantages of Using Deuterated Sodium Borohydride-d4

Researchers prefer Sodium Borohydride-d4 because it offers several important advantages:

• Efficient transfer of deuterium atoms
• High labeling efficiency
• Reliable reduction of carbonyl compounds
• Excellent reproducibility
• Compatible with numerous synthetic procedures
• Suitable for stable isotope labeling studies
• Supports quantitative analytical method development
• Enables preparation of high-quality reference standards

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Importance in Stable Isotope Chemistry

Stable isotope labeling has become increasingly valuable in pharmaceutical and analytical sciences. Deuterium-labeled compounds provide measurable mass differences while maintaining chemical properties very similar to their non-labeled counterparts.

This similarity allows scientists to accurately compare labeled and unlabeled molecules during chromatographic separation and mass spectrometric analysis. Consequently, Deuterated Sodium Borohydride-d4 remains one of the most widely used reagents for introducing deuterium into organic molecules.

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Quality Considerations

For isotope-labeling applications, reagent quality directly impacts experimental accuracy and reproducibility. Researchers typically evaluate:

• Chemical purity
• Deuterium enrichment
• Batch consistency
• Moisture content
• Product stability
• Documentation and traceability

High-quality NaBD₄ helps ensure reliable synthesis of labeled compounds suitable for analytical, pharmaceutical, and research applications.

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Why Choose ResolveMass Laboratories Inc.?

ResolveMass Laboratories Inc. is committed to supplying premium stable isotope-labeled compounds and specialty research chemicals for pharmaceutical, biotechnology, academic, and analytical laboratories. Our Deuterated Sodium Borohydride-d4 is manufactured and supplied with a focus on quality, consistency, and dependable performance to support demanding research workflows.

Whether your work involves isotope labeling, LC-MS internal standards, metabolite identification, medicinal chemistry, or synthetic method development, ResolveMass Laboratories Inc. provides trusted deuterated reagents designed to meet the needs of modern research laboratories.

 

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