Diethylamine-d10 | CAS 120092-66-2

OVERVIEW
Diethylamine-d₁₀ is the fully deuterated isotopologue of diethylamine, a simple aliphatic secondary amine widely used in organic synthesis, analytical chemistry, and isotope labeling studies. In this compound, all ten hydrogen atoms of the ethyl groups are replaced by deuterium, increasing its molecular weight by 10 Da while preserving the identical chemical structure and reactivity of the non-deuterated form.

As a stable isotope-labeled reagent, diethylamine-d₁₀ plays a vital role in analytical and mechanistic chemistry. It is frequently employed as an internal standard in gas chromatography–mass spectrometry (GC-MS) and liquid chromatography–mass spectrometry (LC-MS), as well as in nuclear magnetic resonance (NMR) spectroscopy. Its chemical behavior mirrors that of diethylamine, making it ideal for isotopic tracing, kinetic isotope effect (KIE) measurements, and reaction mechanism elucidation.

CHEMICAL INFORMATION

• Name: Diethylamine-d₁₀

• Molecular Formula: C₄D₁₀N

• Molecular Weight: 83.20 g/mol

• CAS Number: 120092-66-2

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated aliphatic amine; stable isotope-labeled compound

• Stability: Stable under standard laboratory conditions; may react with strong oxidizers or acids

APPLICATIONS  of  Diethylamine-d10 | CAS 120092-66-2

• Analytical Internal Standard for GC-MS and LC-MS:
  Diethylamine-d₁₀ is used as a deuterated internal standard for quantification of diethylamine and related amines in various analytical matrices. Its isotopic shift (+10 Da) ensures precise discrimination between labeled and unlabeled species, enhancing accuracy in quantitative mass spectrometry.

• NMR Spectroscopy:
  Serves as a deuterated compound for chemical shift referencing, calibration, and proton-deuterium exchange studies. It provides valuable data in both ¹H and ²H NMR analyses due to reduced proton signal interference.

• Stable Isotope Labeling Studies:
  Employed as a tracer in chemical and biochemical research to study metabolic pathways, reaction mechanisms, and amine-based transformations.

• Kinetic Isotope Effect (KIE) Research:
  Used to investigate reaction kinetics where hydrogen-deuterium substitution alters reaction rates, helping elucidate bond cleavage processes and transition-state properties.

• Synthetic Chemistry Applications:
  Acts as a labeled precursor for the synthesis of deuterated pharmaceuticals, agrochemicals, and intermediates. Its reactivity as a secondary amine allows for formation of deuterated amides, imines, and tertiary amines.

ADVANTAGES  of  Diethylamine-d10 | CAS 120092-66-2

• Fully deuterated (10D) structure provides consistent isotopic labeling

• High isotopic and chemical purity for reproducible analytical outcomes

• Retains identical reactivity and volatility to native diethylamine

• Non-radioactive, stable, and safe isotope source

• Ideal for both industrial and academic research applications

HANDLING, STORAGE & SAFETY

• Hazards: Highly flammable liquid and vapor; causes skin, eye, and respiratory irritation; harmful if inhaled or ingested.

• Precautions: Handle under a fume hood with proper ventilation. Keep away from heat, sparks, and open flames. Use protective gloves, safety goggles, and suitable lab clothing.

• Storage: Store in tightly sealed containers under an inert atmosphere (nitrogen or argon). Keep cool and dry.

• Spill and Disposal: Absorb spills with non-combustible materials (e.g., vermiculite). Dispose of in accordance with local environmental regulations.

Safety Note: Even though diethylamine-d₁₀ is a stable compound, its volatility and flammability require standard laboratory safety precautions during handling.

QUALITY & SPECIFICATION

• Chemical Purity: ≥ 98 %

• Isotopic Enrichment: ≥ 98 atom % D

• Water Content: ≤ 0.05 %

• Analytical Verification: Characterized by ¹H NMR, ²H NMR, IR spectroscopy, and GC-MS to confirm isotopic incorporation

• Appearance: Clear, colorless liquid

• COA Availability: Each batch includes a Certificate of Analysis verifying isotopic enrichment and chemical composition

SUMMARY
Diethylamine-d₁₀ (CAS 120092-66-2) is a high-purity, fully deuterated analog of diethylamine designed for advanced analytical, synthetic, and mechanistic applications. Its complete deuterium substitution and high isotopic enrichment make it ideal for use as an internal standard in MS and NMR, as well as for tracer studies and kinetic isotope effect research. Combining chemical stability, isotopic precision, and safety, diethylamine-d₁₀ is an essential reagent for laboratories engaged in isotope labeling and molecular analysis.