DL-Leucine-d10 | CAS 29909-01-1

OVERVIEW  of  DL-Leucine-d10 | CAS 29909-01-1

DL-Leucine-d10 (CAS 29909-01-1) is a fully deuterated, isotopically labeled form of DL-leucine containing ten deuterium atoms. As an essential branched-chain amino acid (BCAA), leucine plays a key role in protein synthesis, metabolic regulation, and cellular signaling pathways. The deuterated analog, DL-Leucine-d10, provides precise mass differentiation for advanced LC-MS and GC-MS analytical workflows, enabling accurate quantitation, metabolic tracing, and internal standardization in complex biological samples.
This compound is widely used in metabolomics, nutritional biochemistry, proteomics research, isotope-dilution mass spectrometry, and pharmaceutical development. ResolveMass Laboratories Inc. manufactures DL-Leucine-d10 under stringent purity and isotopic enrichment standards to support high-precision research and regulated laboratory environments.

CHEMICAL INFORMATION
Chemical Name: DL-Leucine-d10
Synonyms: d10-DL-Leucine; Perdeuterated leucine
CAS Number: 29909-01-1
Molecular Formula: C₆H₂D₁₀NO₂
Molecular Weight: 141.24 g/mol
Isotopic Enrichment: ≥98 atom % D

APPLICATIONS  of  DL-Leucine-d10 | CAS 29909-01-1

• Metabolomics & Systems Biology: Ideal for tracing amino acid metabolism, BCAA turnover, and cellular energy pathways.

• LC-MS/GC-MS Internal Standard: Enables accurate quantification of leucine in plasma, serum, urine, tissues, and cell extracts.

• Proteomics Research: Supports peptide/protein quantitation and stable isotope labeling in mass spectrometry (SILAC and related methods).

• Nutritional & Clinical Studies: Used in metabolic flux analysis for studying muscle metabolism, insulin response, and dietary supplementation.

• Pharmaceutical Development: Aids in PK/PD studies, impurity profiling, and formulation analysis involving leucine derivatives.

• Biochemical Research: Facilitates studies on protein synthesis regulation, mTOR pathway signaling, and metabolic disorders.

FEATURES & BENEFITS

• High Deuterium Incorporation: Ensures excellent mass separation and clear isotopic resolution.

• Structurally Equivalent to Native Leucine: Behaves identically in biological and chemical systems, enabling accurate comparative quantitation.

• Exceptional Purity: Suitable for regulated laboratories, clinical workflows, and high-precision research.

• Stable & Reliable: Maintains isotopic integrity during sample preparation and analysis.

• Versatile Analytical Compatibility: Ideal for LC-MS, GC-MS (after derivatization), and NMR studies.

SUMMARY
DL-Leucine-d10 (CAS 29909-01-1) is a high-purity, perdeuterated amino acid designed for accurate mass spectrometric quantitation, metabolic pathway research, proteomics, and nutritional biochemical analysis. With ten deuterium atoms providing excellent isotopic separation, it supports high-precision LC-MS/GC-MS workflows across clinical, pharmaceutical, and academic research sectors.

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