Ethylene-d4-diamine | CAS 37164-19-5

OVERVIEW  of  Ethylene-d4-diamine | CAS 37164-19-5
Ethylene-d₄-diamine (CAS 37164-19-5) is a fully deuterated analog of ethylenediamine, a simple yet versatile aliphatic diamine used in chemical synthesis and analytical studies. In this isotopically labeled compound, all four hydrogen atoms on the carbon backbone are replaced with deuterium, giving it enhanced value for nuclear magnetic resonance (NMR), mass spectrometry (MS), and isotope tracing applications. Owing to its high isotopic enrichment and chemical stability, it serves as an important reagent in kinetic isotope effect investigations, mechanistic chemistry, and the synthesis of deuterium-labeled intermediates.

CHEMICAL INFORMATION

• Name: Ethylene-d₄-diamine

• Molecular Formula: C₂D₄N₂

• Molecular Weight: 64.12 g/mol

• CAS Number: 37164-19-5

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated aliphatic diamine

• Solubility: Completely miscible with water, ethanol, and most polar organic solvents

APPLICATIONS  of  Ethylene-d4-diamine | CAS 37164-19-5

• NMR Spectroscopy:
  Ethylene-d₄-diamine is extensively used as a deuterated reference compound in NMR studies. The deuterium atoms replace active protons, minimizing proton–deuterium coupling and improving spectral resolution for complex amine systems.

• Mass Spectrometry (MS):
  Functions as a stable isotope-labeled internal standard in quantitative MS analysis of diamine derivatives. The 4 Da mass shift from its non-deuterated counterpart allows clear differentiation and accurate quantification.

• Isotopic Tracing & Kinetic Studies:
  Valuable in mechanistic and kinetic isotope effect studies, allowing researchers to trace hydrogen exchange, reaction pathways, and transformation mechanisms in both organic and biochemical processes.

• Synthetic Chemistry:
  Serves as a deuterated precursor for synthesizing labeled pharmaceuticals, coordination complexes, and polymeric materials requiring isotope tracking. Its high chemical reactivity and isotopic integrity make it ideal for controlled deuterium incorporation.

ADVANTAGES  of  Ethylene-d4-diamine | CAS 37164-19-5

• High isotopic purity (≥ 98 atom % D) ensures analytical precision.

• Chemically and thermally stable under standard conditions.

• Provides clear isotopic separation in NMR and MS analyses.

• Compatible with both aqueous and organic solvents.

• Ideal for isotope effect and mechanistic chemistry research.

HANDLING AND SAFETY

• Handling Precautions: Avoid inhalation and direct contact. Handle in a well-ventilated area.

• Protective Equipment: Use gloves, safety goggles, and protective clothing.

• Storage: Store in a cool, dry, inert atmosphere to prevent oxidation or moisture absorption.

• Stability: Stable under standard laboratory conditions; hygroscopic when exposed to air.

• Disposal: Dispose of according to institutional and regional regulations for amine compounds and deuterated materials.

SUMMARY
Ethylene-d₄-diamine (CAS 37164-19-5) is a fully deuterated ethylenediamine that provides exceptional performance in isotope labeling, NMR, and MS studies. Its structural simplicity, isotopic purity, and stability make it an essential reagent in chemical synthesis, reaction mechanism elucidation, and isotope tracing research, supporting precision-driven analytical and synthetic applications.