Furan-d4 | CAS 6142-90-1

OVERVIEW  of  Furan-d4 | CAS 6142-90-1

Furan-d4 is a deuterium-labeled derivative of furan, an aromatic five-membered heterocyclic compound containing one oxygen atom. The substitution of hydrogen atoms with deuterium creates a stable isotopic variant that maintains identical chemical and physical characteristics while exhibiting a distinct isotopic mass shift (+4 Da).

Due to its volatility, stability, and electron-rich aromatic nature, Furan-d4 is widely used in quantitative analytical methods, mechanistic organic chemistry, and stable isotope labeling applications. The compound’s unique isotopic properties allow precise calibration, quantification, and differentiation of unlabeled furans and related metabolites in both research and industrial contexts.

CHEMICAL INFORMATION

• Chemical Name: Furan-d4

• Synonyms: Tetra-deuterofuran; Deuterated furan

• CAS Number: 6142-90-1

• Molecular Formula: C₄D₄O

• Molecular Weight: 72.10 g/mol

• Isotopic Enrichment: ≥ 99 atom % D

• Purity: ≥ 99%

• Chemical Class: Deuterated heterocyclic aromatic compound

DESCRIPTION AND PROPERTIES
Furan-d4 is a volatile, aromatic, oxygen-containing heterocycle that exhibits a high degree of stability under standard analytical conditions. The incorporation of deuterium atoms produces a predictable isotopic mass shift, allowing it to be used as a reference compound in GC-MS and LC-MS quantification.

This compound is often selected for use in isotope dilution methods and kinetic isotope effect studies because of its consistent deuterium retention and minimal hydrogen–deuterium exchange. Its low boiling point and distinctive fragmentation pattern make it particularly suitable for studies involving volatile organic compounds (VOCs), synthetic intermediates, and environmental pollutants.

APPLICATIONS  of  Furan-d4 | CAS 6142-90-1

1. Mass Spectrometry (GC-MS, LC-MS):
   Furan-d4 serves as a stable isotopic internal standard in the analysis of furan and related heterocycles in environmental, food, and pharmaceutical matrices.

2. NMR Spectroscopy:
   Functions as a deuterated solvent or calibration standard in ^1H and ^13C NMR analyses, providing clean background signals for aromatic heterocycles.

3. Metabolomic and Environmental Tracing:
   Used in metabolic pathway elucidation, environmental fate studies, and reaction tracking where isotopic labeling aids in compound differentiation and quantification.

4. Synthetic and Mechanistic Studies:
   Acts as an isotopic label in mechanistic organic chemistry, particularly in electrophilic substitution, oxidation, and ring-opening reactions involving furans.

5. Quality Control and Calibration:
   Serves as a calibration reference for trace-level detection of furan contaminants in industrial and analytical quality control workflows.

ANALYTICAL ADVANTAGES

• Fully deuterated structure provides a +4 Da mass shift for isotopic differentiation

• Non-exchangeable deuterium atoms ensure excellent isotopic stability

• Chemically equivalent to native furan for consistent chromatographic behavior

• Ideal for volatile compound analysis and isotopic tracer studies

• High isotopic enrichment and analytical-grade purity

QUALITY AND MANUFACTURING
At ResolveMass Laboratories Inc., Furan-d4 is synthesized under strictly controlled conditions using catalytic deuteration and isotopic exchange processes. Each batch undergoes rigorous testing via GC-MS, NMR, and FTIR spectroscopy to confirm isotopic enrichment, purity, and molecular identity.

Our production standards meet or exceed international research-grade specifications, ensuring that each vial of Furan-d4 provides reproducible results in analytical and research applications. The compound is supplied in sealed, high-integrity containers to preserve isotopic stability and minimize volatilization losses.

CONCLUSION
Furan-d4 (CAS 6142-90-1) is a high-quality, fully deuterated heterocyclic compound essential for precision analytical, synthetic, and spectroscopic research. Its stable isotopic labeling and predictable mass shift make it indispensable for mass spectrometry calibration, NMR reference analysis, and tracer studies.

Offered by ResolveMass Laboratories Inc., Furan-d4 embodies superior isotopic purity, stability, and reproducibility—making it a trusted choice for researchers conducting advanced studies in organic synthesis, metabolomics, and environmental chemistry.

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