Glycine-2,2-d2 | CAS 4896-75-7

OVERVIEW  of  Glycine-2,2-d2 | CAS 4896-75-7

Glycine-2,2-d2 (CAS 4896-75-7) is a deuterium-labeled form of glycine, the simplest amino acid and an essential component in metabolic, biochemical, and analytical research. This isotopologue contains two deuterium atoms at the 2-position, allowing precise mass differentiation in LC-MS, GC-MS, and NMR applications. Because glycine is central to numerous physiological processes—including collagen synthesis, neurotransmission, one-carbon metabolism, and detoxification pathways—the deuterated version is an indispensable tool for metabolic tracing, flux analysis, and quantitative bioanalysis.

Produced with high isotopic purity at ResolveMass Laboratories Inc., Glycine-2,2-d2 supports advanced research in amino acid metabolism, biomarker discovery, pharmacokinetics, nutritional sciences, and stable isotope-resolved metabolomics (SIRM). Its chemical behavior closely mirrors native glycine, ensuring consistent analytical performance while providing a clear mass shift for accurate detection.

CHEMICAL INFORMATION

• Chemical Name: Glycine-2,2-d2

• Synonyms: 2,2-Dideutero-glycine, Deuterated glycine

• CAS Number: 4896-75-7

• Molecular Formula: C₂H₃D₂NO₂

• Molecular Weight: 77.08 g/mol

• Isotopic Enrichment: ≥98 atom % D

• Functional Groups: Primary amine (NH₂), carboxylic acid (COOH)

APPLICATIONS  of  Glycine-2,2-d2 | CAS 4896-75-7

• Metabolic Flux & Isotope Tracing: Helps track glycine incorporation into proteins, glutathione synthesis, and one-carbon metabolism through SIRM studies.

• Internal Standard for LC-MS & GC-MS: Provides accurate quantitation of glycine in plasma, urine, tissues, food products, and fermentation samples.

• Nutritional Biochemistry: Supports investigations into dietary amino acid absorption, nitrogen balance, and metabolic turnover.

• Biomedical & Clinical Research: Used in studies related to oxidative stress, inflammatory markers, mitochondrial metabolism, and glycine-dependent neurotransmission.

• Pharmaceutical Research: Assists in validating analytical methods, evaluating drug effects on amino acid pathways, and studying metabolic biomarkers.

• Quality Control & Standardization: Useful in calibration curves, method validation, and establishing accuracy in regulated bioanalytical environments.

FEATURES & BENEFITS

• High Isotopic Stability: Ensures reliable mass separation and consistent performance in analytical workflows.

• Chemically Identical to Native Glycine: Provides identical chromatographic and biochemical behavior, critical for precise quantitation.

• Versatile Research Utility: Suitable for metabolomics, clinical chemistry, proteomics, nutrition studies, and pharmaceutical analysis.

• Low Background Noise: Deuterium labeling minimizes interference and enhances signal clarity in mass spectrometry.

• Produced to Research-Grade Quality: Manufactured by ResolveMass Laboratories Inc. under stringent quality protocols, ensuring purity and reproducibility.

• Custom Deuterated Glycine Derivatives Available: Tailored isotopic labeling patterns can be synthesized to support specialized pathways and research goals.

SUMMARY
Glycine-2,2-d2 (CAS 4896-75-7) is a high-purity, deuterium-labeled amino acid essential for metabolic flux studies, quantitative LC-MS/MS analysis, nutritional biochemistry, and clinical research. With two deuterium atoms providing a distinct mass advantage, it enables precise quantitation and pathway tracking without altering glycine’s native biochemical properties. Offered by ResolveMass Laboratories Inc., this compound meets the analytical needs of metabolomics labs, pharmaceutical researchers, and academic institutions conducting advanced biochemical investigations.

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