Glycine-2,2-d2-N-tBoc | CAS 42492-65-9

OVERVIEW  of  Glycine-2,2-d2-N-tBoc | CAS 42492-65-9

Glycine-2,2-d2-N-tBoc (CAS 42492-65-9) is a deuterium-labeled, N-tert-butoxycarbonyl protected derivative of glycine, designed for advanced synthetic, biochemical, and analytical applications. Incorporating two deuterium atoms at the 2-position and a Boc protective group on the amino functionality, this compound is highly useful in peptide synthesis, isotopic labeling studies, and stable isotope-resolved metabolomics (SIRM). The Boc group provides stability and selectivity in multi-step organic synthesis while preserving the integrity of the deuterium labeling.

At ResolveMass Laboratories Inc., Glycine-2,2-d2-N-tBoc is manufactured with high isotopic enrichment and chemical purity, making it ideal for incorporation into deuterium-labeled peptides, metabolic probes, and standards for LC-MS and NMR workflows. It is widely used in pharmaceutical R&D, bioconjugation chemistry, synthetic pathway optimization, and targeted metabolomics.

CHEMICAL INFORMATION

• Chemical Name: Glycine-2,2-d2-N-tert-butoxycarbonyl

• Synonyms: Boc-Glycine-d2, N-Boc-2,2-d2-glycine, Deuterated Boc-glycine

• CAS Number: 42492-65-9

• Molecular Formula: C₇H₁₁D₂NO₄

• Molecular Weight: 192.23 g/mol

• Isotopic Enrichment: ≥98 atom % D

• Protective Group: tert-Butoxycarbonyl (Boc)

APPLICATIONS  of  Glycine-2,2-d2-N-tBoc | CAS 42492-65-9

• Peptide & Peptidomimetic Synthesis: Widely used as a building block for preparing deuterium-labeled peptides for mechanistic enzymology, proteomics, and structural biology.

• Stable Isotope-Resolved Metabolomics: Supports metabolic tracing and flux studies involving glycine-related pathways, including glutathione synthesis and one-carbon metabolism.

• Internal Standard for Analytical Methods: Can be used as a protected precursor standard for GC-MS or LC-MS workflows involving derivatization steps.

• Organic Synthesis: Ideal for multi-step synthetic routes requiring amine protection without proton exchange at labeled positions.

• Pharmaceutical Research: Assists in developing labeled drug candidates, metabolic probes, and isotopically defined intermediates.

• Bioconjugation Chemistry: Useful in designing labeled linkers, drug–peptide conjugates, and tracer molecules.

FEATURES & BENEFITS

• Stable Boc Protection: Prevents side reactions and preserves the isotopic label during synthetic transformations.

• High Deuterium Retention: Minimal risk of isotopic exchange under standard reaction conditions.

• Excellent Chemical Purity: Enables consistent performance in pharmaceutical and biochemical applications.

• Versatile in Organic & Biological Chemistry: Functions as both a synthetic intermediate and an analytical reference compound.

• High Compatibility: Suitable for solid-phase peptide synthesis (SPPS) and solution-phase synthesis.

• Custom Synthesis Services: ResolveMass Laboratories offers custom-labeled glycine derivatives and other amino acid isotopologues tailored to specific research requirements.

SUMMARY
Glycine-2,2-d2-N-tBoc (CAS 42492-65-9) is a high-purity, isotopically labeled Boc-protected glycine derivative ideal for peptide synthesis, isotopic labeling studies, metabolomics, and advanced organic chemistry applications. Its stability, high deuterium enrichment, and compatibility with SPPS make it an essential component for preparing deuterated peptides, metabolic tracers, and internal standards. Manufactured by ResolveMass Laboratories Inc., this compound is engineered for accuracy, reproducibility, and high-level research needs across pharmaceutical and biochemical domains.

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