Glycolic-2,2-d2 acid | CAS 75502-10-2

OVERVIEW  of  Glycolic-2,2-d2 acid | CAS 75502-10-2

Glycolic-2,2-d2 acid (CAS 75502-10-2) is a deuterium-labeled α-hydroxy acid, featuring two deuterium atoms at the 2-position. As a deuterated analog of glycolic acid, this compound is particularly valuable in metabolomics, isotope-dilution mass spectrometry (IDMS), pharmaceutical R&D, and environmental analysis. Its isotopic labeling allows for precise mass differentiation without altering the core chemical reactivity of the native acid. This makes Glycolic-2,2-d2 acid ideal for quantitative LC-MS and GC-MS assays, metabolic tracing studies, and calibration workflows.

Produced with high isotopic enrichment by ResolveMass Laboratories Inc., this compound is used extensively in biochemical pathway research, dermatological formulations analysis, industrial process monitoring, and quality control studies involving α-hydroxy acids and related metabolites.

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CHEMICAL INFORMATION

• Chemical Name: Glycolic-2,2-d2 acid

• Synonyms: 2,2-Dideutero-glycolic acid, Deuterated glycolic acid

• CAS Number: 75502-10-2

• Molecular Formula: C₂H₂D₂O₃

• Molecular Weight: 78.06 g/mol

• Isotopic Enrichment: ≥98 atom % D

• Functional Groups: Hydroxyl (OH), carboxylic acid (COOH)

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APPLICATIONS  of  Glycolic-2,2-d2 acid | CAS 75502-10-2

• Metabolomics & Pathway Tracing: Used to study glycolate metabolism, oxidative stress pathways, photorespiration, and peroxisomal function.

• Quantitative LC-MS / GC-MS Analysis: Serves as a stable internal standard for measuring glycolic acid in biological fluids, environmental samples, cosmetic products, and industrial matrices.

• Isotope-Dilution Mass Spectrometry: Provides high accuracy for trace-level quantitation in regulatory and research laboratories.

• Biochemical Research: Supports studies involving α-hydroxy acids, cellular redox states, and metabolic dysregulation.

• Dermatological Science: Useful for analyzing glycolic acid in cosmetic formulations, peels, and dermatology-related research.

• Environmental & Industrial Monitoring: Helps quantify glycolate in products, wastewater, and process streams with high precision.

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FEATURES & BENEFITS

• High Deuterium Stability: Maintains isotopic integrity during typical derivatization and analytical workflows.

• Excellent Chemical Purity: Ensures reproducibility in both research and regulated quantitative assays.

• Structurally Equivalent to Native Glycolic Acid: Enables accurate comparisons and quantitative determinations.

• Versatile Use in Biology, Pharma & Industry: Suitable for metabolomics, QC testing, toxicology, and formulation analysis.

• Low Background Interference: Provides strong analytical signals with minimal matrix effects in LC-MS and GC-MS systems.

• Custom Deuteration Options: ResolveMass Laboratories offers tailored labeled glycolates and related α-hydroxy acids upon request.

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SUMMARY
Glycolic-2,2-d2 acid (CAS 75502-10-2) is a high-purity deuterated α-hydroxy acid designed for quantitative mass spectrometry, metabolic pathway studies, dermatological research, and environmental analysis. With two deuterium atoms enabling precise isotopic tracking, it supports accurate LC-MS and GC-MS quantitation across a diverse range of sample types. Manufactured by ResolveMass Laboratories Inc., this product ensures exceptional chemical integrity and isotopic enrichment for advanced research and analytical applications.

 

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PubChem CID

757