Iso-Propyl alcohol-d8 (2-propanol-d8)| CAS 22739-76-0

OVERVIEW
Iso-Propyl alcohol-d₈ (also known as 2-Propanol-d₈) is a fully deuterated analog of isopropyl alcohol, in which all hydrogen atoms are replaced with deuterium. This isotopic substitution increases the molecular weight and improves analytical detectability in mass spectrometry and NMR spectroscopy. The compound maintains the same physicochemical behavior and solvent properties as regular isopropanol, making it ideal for isotopic labeling, kinetic isotope studies, and solvent use in analytical and spectroscopic applications.

CHEMICAL INFORMATION

• Chemical Name / Synonyms: Iso-Propyl alcohol-d₈

• Molecular Formula: C₃D₈O

• Molecular Weight: 68.14 g/mol

• CAS Number: 22739-76-0

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated secondary alcohol

• Functional Group: Hydroxyl (-OH)

• Stability: Stable under normal temperature and pressure; hygroscopic in nature

APPLICATIONS  of  Iso-Propyl alcohol-d8 (2-propanol-d8)| CAS 22739-76-0

• NMR Spectroscopy Solvent:
  Iso-Propyl alcohol-d₈ is used as a deuterated solvent in NMR spectroscopy, particularly for analyzing organic compounds soluble in alcohols. The high deuterium content minimizes background proton signals, improving spectral clarity and accuracy.

• Mass Spectrometry (MS) Studies:
  Acts as an internal standard or isotopic tracer in MS analyses, providing clear mass separation from non-deuterated analogs and aiding in quantitative isotope dilution analysis.

• Kinetic Isotope Effect (KIE) Experiments:
  Useful in mechanistic studies involving hydrogen/deuterium exchange to explore reaction pathways and bond dissociation energies in alcohol-based systems.

• Tracer in Chemical and Biochemical Reactions:
  Employed to investigate hydrogen transfer and exchange reactions, solvent interactions, and isotope labeling in both synthetic and biological systems.

• Solvent for Sensitive Reactions:
  Serves as a deuterated solvent medium for reactions requiring proton-free conditions, minimizing interference in hydrogen-sensitive processes.

ADVANTAGES  of  Iso-Propyl alcohol-d8 (2-propanol-d8)| CAS 22739-76-0

• High isotopic enrichment ensures accurate isotope tracing and analytical reproducibility.

• Fully deuterated structure eliminates interfering proton peaks in NMR spectra.

• Chemically equivalent to non-deuterated isopropanol, allowing direct comparison in kinetic or solubility studies.

• Compatible with a wide range of analytical instruments and techniques.

• Non-radioactive and environmentally safe isotopic labeling reagent.

HANDLING

• Hazards: Flammable liquid and vapor; may cause eye and skin irritation; harmful if inhaled or ingested in large amounts.

• Precautions: Handle under well-ventilated conditions away from open flames or heat sources. Use appropriate protective equipment including gloves, goggles, and lab coats.

• Storage: Keep in a cool, dry, and well-ventilated area; tightly sealed containers recommended. Avoid contact with strong oxidizers.

• Spill Response: Absorb with inert material and dispose of according to local chemical waste regulations.

QUALITY & SPECIFICATION
Each batch of Iso-Propyl alcohol-d₈ is subjected to strict quality controls to ensure purity and isotopic composition:

• Deuterium Enrichment: ≥ 98 atom % D

• Chemical Purity: ≥ 99 %

• Water Content: ≤ 0.02 %

• NMR Verification: Absence of residual proton signals

• Mass Spectrometry: Confirms molecular integrity and isotopic uniformity

SUMMARY
Iso-Propyl alcohol-d₈ (2-Propanol-d₈) is a high-purity, fully deuterated solvent and isotopic reagent widely used in analytical chemistry, spectroscopy, and reaction mechanism studies. With excellent isotopic enrichment, stability, and chemical compatibility, it serves as a reliable standard in NMR and MS applications. Its deuterium substitution ensures low background interference, making it indispensable for precision analytical work and isotope-based kinetic investigations.

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